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温经汤加味对EM肾虚血瘀证大鼠局部微环境MMP-9、TNF-α、Collagen Ⅰ、Collagen Ⅲ的影响及其意义 被引量:5
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作者 崔轶凡 孙瑞英 +3 位作者 王志平 曹娟 刘宏奇 李培硕 《世界科学技术-中医药现代化》 CSCD 北大核心 2021年第8期2719-2726,共8页
目的探讨子宫内膜异位症(Endometosis,EM)肾虚血瘀证大鼠异位病灶局部MMP-9,TNF-α,CollagenⅠ、CollagenⅢ表达水平,以及温经汤加味对其干预作用及机制。方法SPF级雌性未孕健康SD大鼠设为空白组;构建肾虚血瘀证大鼠模型,造模成功后,设... 目的探讨子宫内膜异位症(Endometosis,EM)肾虚血瘀证大鼠异位病灶局部MMP-9,TNF-α,CollagenⅠ、CollagenⅢ表达水平,以及温经汤加味对其干预作用及机制。方法SPF级雌性未孕健康SD大鼠设为空白组;构建肾虚血瘀证大鼠模型,造模成功后,设为假手术组(仅开腹);其余大鼠以自体内膜移植法构建EM肾虚血瘀证模型,造模成功后的大鼠分为模型组(不用药物干预)、阳性药(达那唑)组、温经汤加味组(低、中、高3种剂量)。阳性药对照组给予达那唑63 mg·kg^(-1)连续4周灌胃,中药低、中、高剂量组分别以5 g·kg^(-1)、10 g·kg^(-1)、20 g·kg^(-1)连续4周灌胃。取各组大鼠子宫内膜组织观察组织病理变化;免疫组化法(IHC)检测各组大鼠子宫内膜组织MMP-9,TNF-α的蛋白表达;蛋白免疫印迹法(WB)、实时荧光聚合酶链式反应法(RT-PCR)检测各组大鼠子宫内膜组织MMP-9、TNF-α、CollagenⅠ、CollagenⅢ基因表达。结果与空白组、假手术组比较,EM肾虚血瘀证模型组大鼠在位、异位内膜组织中MMP-9、TNF-α、CollagenⅠ、CollagenⅢ蛋白及其基因表达在模型组子宫内膜组织升高(P<0.01);与模型组比较,阳性药对照组、温经汤加味治疗组大鼠MMP-9、TNF-α、CollagenⅠ、CollagenⅢ蛋白及其基因表达水平均降低(P<0.01或P<0.05)。结论局部微环境免疫抑制微血管新生导致异位内膜侵袭是EM发生、发展过程中的重要病理表现,MMP-9、TNF-α、CollagenⅠ、CollagenⅢ过度表达可能促进了这一过程的发生、发展;温经汤加味通过"逆转"MMP-9、TNF-α、CollagenⅠ、CollagenⅢ等细胞因子异常升高,起到了解除局部微环境免疫抑制、阻断微血管新生的作用,在治疗EM肾虚血瘀证过程中表现出确切的疗效。 展开更多
关键词 子宫内膜异位症 MMP-9 TNF-Α CollagenⅠ CollagenⅢ 金匮温经汤加味
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Discrimination of Natural Fractures Using Well Logging Curve Unit 被引量:3
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作者 liuhongqi PengShimi +1 位作者 ZhouYongyi XueYongchao 《Journal of China University of Geosciences》 SCIE CSCD 2004年第4期372-378,共7页
It is very difficult to discriminate natural fractures using conventional well log data, especially for most of the matured oilfields in China, because the raw data were acquired with relatively obsolete tools. The ra... It is very difficult to discriminate natural fractures using conventional well log data, especially for most of the matured oilfields in China, because the raw data were acquired with relatively obsolete tools. The raw data include only GR and SP curves, indicative of lithology, AC curves, used to calculate the porosity of the formation, and a set of logging curves from various electrode length resistivity by laterolog. On the other hand, these oilfields usually have a large amount of core data which directly display the characteristics of the formation, and enough information of injection and production. This paper describes an approach through which logging curves are calibrated in terms of the raw data, and then a prototype model of natural fractures is established based on the investigation of core data from 43 wells, totaling 4 000 m in length. A computer program has been developed according to this method. Through analysis and comparison of the features of logging curves, this paper proposes a new concept, the well logging curve unit. By strictly depicting its shape through mathematical methods, the natural facture can be discriminated. This work also suggests an equation to estimate the probability of fracture occurrence, and finally other fracture parameters are calculated using some experimental expressions. With this methodology, logging curves from 100 wells were interpreted, the results of which agree with core data and field information. 展开更多
关键词 Jilin oilfield fracture well logging curve unit quantitative discrimination.
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