When speaking of Shanghai’s bars, what comes to people’s minds first must be Hengshan Street, a road known for its variety of bars. For many people, Hengshan Street is a landmark. On this street, bars in bold and un...When speaking of Shanghai’s bars, what comes to people’s minds first must be Hengshan Street, a road known for its variety of bars. For many people, Hengshan Street is a landmark. On this street, bars in bold and unrestrained styles appeal to visitors. In fact, the whole street is a large open bar: the hurly-burly of "Hello" permeates every corner of the street; the resonant singing of "Rainbow Potato" echoes in the night sky; the rock’n roll of "Full House" fascinates passers-by with the wildness of John Lennon;展开更多
Background MicroRNAs （miRNAs） control gene expression by destabilizing target transcripts and inhibiting their translation. Aberrant expression of miRNAs has been described in many human diseases, including schizoph...Background MicroRNAs （miRNAs） control gene expression by destabilizing target transcripts and inhibiting their translation. Aberrant expression of miRNAs has been described in many human diseases, including schizophrenia. However, the effects on miRNA expression in response to antipsychotic treatment in peripheral circulation have not been thoroughly examined. Methods Using quantitative real-time PCR （qRT-PCR）, We quantified the expression of seven candidate miRNAs in plasma samples of 40 first-episode schizophrenics before and after antipsychotic treatment. The patients were all treated with risperidone and achieved remission in 1 year. Results Compared with the baseline, the expression levels of miR-365 and miR-520c-3p were significantly down- regulated after 1 year of risperidone treatment （P 〈0.001）. There were no significant correlations between the clinical symptoms and the expression levels of these two miRNAs （P 〉0.05）. Conclusions This study analyzed possible circulating miRNAs in response to antipsychotic monotherapy for schizophrenia, the further mechanism need to be confirmed.展开更多
文摘When speaking of Shanghai’s bars, what comes to people’s minds first must be Hengshan Street, a road known for its variety of bars. For many people, Hengshan Street is a landmark. On this street, bars in bold and unrestrained styles appeal to visitors. In fact, the whole street is a large open bar: the hurly-burly of "Hello" permeates every corner of the street; the resonant singing of "Rainbow Potato" echoes in the night sky; the rock’n roll of "Full House" fascinates passers-by with the wildness of John Lennon;
文摘Background MicroRNAs （miRNAs） control gene expression by destabilizing target transcripts and inhibiting their translation. Aberrant expression of miRNAs has been described in many human diseases, including schizophrenia. However, the effects on miRNA expression in response to antipsychotic treatment in peripheral circulation have not been thoroughly examined. Methods Using quantitative real-time PCR （qRT-PCR）, We quantified the expression of seven candidate miRNAs in plasma samples of 40 first-episode schizophrenics before and after antipsychotic treatment. The patients were all treated with risperidone and achieved remission in 1 year. Results Compared with the baseline, the expression levels of miR-365 and miR-520c-3p were significantly down- regulated after 1 year of risperidone treatment （P 〈0.001）. There were no significant correlations between the clinical symptoms and the expression levels of these two miRNAs （P 〉0.05）. Conclusions This study analyzed possible circulating miRNAs in response to antipsychotic monotherapy for schizophrenia, the further mechanism need to be confirmed.
