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Emerging roles of plasmacytoid dendritic cell crosstalk in tumor immunity 被引量:1
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作者 Leilei Yang Songya Li +1 位作者 liuhui chen Yi Zhang 《Cancer Biology & Medicine》 SCIE CAS CSCD 2023年第10期728-747,共20页
Plasmacytoid dendritic cells(pDCs)are a pioneer cell type that produces type I interferon(IFN-I)and promotes antiviral immune responses.However,they are tolerogenic and,when recruited to the tumor microenvironment(TME... Plasmacytoid dendritic cells(pDCs)are a pioneer cell type that produces type I interferon(IFN-I)and promotes antiviral immune responses.However,they are tolerogenic and,when recruited to the tumor microenvironment(TME),play complex roles that have long been a research focus.The interactions between p DCs and other components of the TME,whether direct or indirect,can either promote or hinder tumor development;consequently,p DCs are an intriguing target for therapeutic intervention.This review provides a comprehensive overview of p DC crosstalk in the TME,including crosstalk with various cell types,biochemical factors,and microorganisms.An in-depth understanding of p DC crosstalk in TME should facilitate the development of novel p DC-based therapeutic methods. 展开更多
关键词 Plasmacytoid dendritic cell tumor microenvironment cell crosstalk immune activation immune suppression
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