One of the challenges in developing three-dimensional printed medicines is related to their stability due to the manufacturing conditions involving high temperatures.This work proposed a new protocol for preformulatio...One of the challenges in developing three-dimensional printed medicines is related to their stability due to the manufacturing conditions involving high temperatures.This work proposed a new protocol for preformulation studies simulating thermal processing and aging of the printed medicines,tested regarding their morphology and thermal,crystallographic,and spectroscopic profiles.Generally,despite the strong drug-polymer interactions observed,the chemical stability of the model drugs was preserved under such conditions.In fact,in the metoprolol and Soluplus®composition,the drug's solubilization in the polymer produced a delay in the drug decomposition,suggesting a protective effect of the matrix.Paracetamol and polyvinyl alcohol mixture,in turn,showed unmistakable signs of thermal instability and chemical decomposition,in addition to physical changes.In the presented context,establishing protocols that simulate processing and storage conditions may be decisive for obtaining stable pharmaceutical dosage forms using three-dimensional printing technology.展开更多
A tablet microstructure,especially the porosity,is a crucial parameter that influences the mechanical properties.Herein,tablet subdivisions were studied as a functi on of tablet porosity.The tablets were manufactured ...A tablet microstructure,especially the porosity,is a crucial parameter that influences the mechanical properties.Herein,tablet subdivisions were studied as a functi on of tablet porosity.The tablets were manufactured in the presenee of different diluents,namely microcrystalline cellulose,LudipressR,or lactose monohydrate.Furthermore,the add让ion of Camphor was investigated,which was thereafter sublimated with a view of obtaining tablets having varying degrees of porosity.Microstructural assays were corre lated to the subdivision performs nee.The increase in porosity reduced the hardness and increased the tablet friability,adversely impacting the subdivision.For all the excipients,an increase in relative porosity>90%represented the threshold level from which an inadequate subdivision occurred.The in crease in tablet porosity led to a reduction in mechanical resista nee,which,combined with a heterogeneous and disc on tinuous distribution of pores within the matrix,resulted in poor subdivision results.Con trolling tablet porosity is an important consideration when designing tablets having a subdivision purpose.展开更多
基金supported by the Brazilian agencies DPI/UnB,FAP-DF(Grant No.:193.001.741/2017),and CNPq(Grant No.:408291/2018e4).
文摘One of the challenges in developing three-dimensional printed medicines is related to their stability due to the manufacturing conditions involving high temperatures.This work proposed a new protocol for preformulation studies simulating thermal processing and aging of the printed medicines,tested regarding their morphology and thermal,crystallographic,and spectroscopic profiles.Generally,despite the strong drug-polymer interactions observed,the chemical stability of the model drugs was preserved under such conditions.In fact,in the metoprolol and Soluplus®composition,the drug's solubilization in the polymer produced a delay in the drug decomposition,suggesting a protective effect of the matrix.Paracetamol and polyvinyl alcohol mixture,in turn,showed unmistakable signs of thermal instability and chemical decomposition,in addition to physical changes.In the presented context,establishing protocols that simulate processing and storage conditions may be decisive for obtaining stable pharmaceutical dosage forms using three-dimensional printing technology.
基金Brazilian agencies FAP-DF(project number 0193.001464/2016),CNPq,and CAPES.
文摘A tablet microstructure,especially the porosity,is a crucial parameter that influences the mechanical properties.Herein,tablet subdivisions were studied as a functi on of tablet porosity.The tablets were manufactured in the presenee of different diluents,namely microcrystalline cellulose,LudipressR,or lactose monohydrate.Furthermore,the add让ion of Camphor was investigated,which was thereafter sublimated with a view of obtaining tablets having varying degrees of porosity.Microstructural assays were corre lated to the subdivision performs nee.The increase in porosity reduced the hardness and increased the tablet friability,adversely impacting the subdivision.For all the excipients,an increase in relative porosity>90%represented the threshold level from which an inadequate subdivision occurred.The in crease in tablet porosity led to a reduction in mechanical resista nee,which,combined with a heterogeneous and disc on tinuous distribution of pores within the matrix,resulted in poor subdivision results.Con trolling tablet porosity is an important consideration when designing tablets having a subdivision purpose.
