A method of elevated temperatures coupled with magnetic stirring to predict real time release from long acting progesterone PLGA microspheres

The object of the study was to develop a quick and reproducible accelerated in vitro release method to predict and deduce the function of the real time(37 °C) release for long acting PLGA microspheres. The method could be described in several steps. First, the release of the microspheres were studied using the sample and separate method at 37 °C with normal orbital shaking and elevated temperatures with magnetic stirring to further accelerate the release. Second, the most similar profile at elevated temperatures with the real time release was chosen with the help of the n value in the fitted Korsmeyer-Peppas Function. Third,the Weibull function and conversion ratio were used to deduce the function of real time release according to the chosen profile at elevated temperatures. The key point in this study was to provide a quick and precise method to predict the real time release for long acting progesterone PLGA microspheres. So the elevated temperatures coupled with magnetic stirring were used to accelerate the release further, and when there have many similar release profiles with the real time release at elevated temperatures, releasing time at elevated temperatures and the R2 of the final deduced function will be used to help choosing the most similar release profile with the real time release. Four different types of progesterone PLGA microspheres were used to verify the method, and all the deduced function correlated well with the real time releases, for R2 = 0.9912, 0.9781, 0.9918 and 0.9972, respectively.

Regional power connectivity in Southeast Asia: the role of regional cooperation

ASEAN is an interesting case study of regional power connectivity in Asia and the Pacific due to its geographic location and ongoing power connectivity within and beyond ASEAN.This paper reviews ASEAN’s power connectivity within ASEAN and between ASEAN and its neighbours(hereafter ASEAN connectivity).Through literature survey,it identifies challenges to the ASEAN connectivity from political,legal,economic and technical perspectives.Based on these analyses,it then explores what,how and when regional cooperation may be able to facilitate ASEAN power connectivity.

The Filial Piety Thought in The Analects and Its Implications for the Filial Culture Education in Rural Areas of China

The Analects is the source of Confucian culture,and filial piety is the traditional virtue of the Chinese nation.The filial piety thought contained in The Analects is profound and concrete.From the macroscopic perspective,it is embodied in the filial piety and loyalty;from the perspective of family filial piety,it manifests itself as the four aspects of the individual s support,respect,courtesy and loyalty to parents.Through the in-depth interpretation of the filial piety in The Analects,and combination of the issues of endowment,education,empty nesters and left-behind children in rural areas,this paper explored its value in the individual,family and social construction.

ADMETNet：The knowledge base of pharmacokinetics and toxicology network

A good drug or drug candidate should not only interact with its target molecule effectively and specifically,but also be absorbed into the body,distributed to the right location,metabolized into right compounds,and eliminated out of the body in proper manner.The processes of drug getting into and out of the body involve Absorption,Distribution,Metabolism,and Excretion（ADME）,