In China, meteorological forecasting relies on meteorological data obtained from regional and national stations. However, there were discrepancies between the data collected from the meteorological station at the pass...In China, meteorological forecasting relies on meteorological data obtained from regional and national stations. However, there were discrepancies between the data collected from the meteorological station at the passion fruit growing base and the data from regional and national stations. Consequently, the high and low temperature disaster indicators determined by the meteorological station at the passion fruit growing base cannot be applied to meteorological forecasting. To address this issue and facilitate the monitoring and early warning of high and low temperature disasters in passion fruit cultivation in Fujian, China, we used multi-source hourly temperature data (including the data from meteorological observation stations in passion fruit growing bases, the nearest regional stations, and national surface conventional meteorological observation stations) in three cities in southwestern Fujian (Longyan, Sanming, and Zhangzhou) spanning the years 2020 to 2022. By employing comprehensive statistical analysis methods (0.5 interval division and Cumulative frequency), we identified that passion fruit in southwestern Fujian was susceptible to high temperature disasters during the blooming-fruiting period, as well as low temperature disasters during the sprouting period. Consequently, we developed high and low temperature disaster indicators based on data from regional and national stations for different phenological periods of passion fruit in this region.展开更多
Venous malformations(VMs) are the most common vascular developmental anomalies. There are many controversies over VMs in Chinese clinical medical practice. Experts on the panel from vascular-anomaly centers in China r...Venous malformations(VMs) are the most common vascular developmental anomalies. There are many controversies over VMs in Chinese clinical medical practice. Experts on the panel from vascular-anomaly centers in China reviewed the etiology, pathophysiology, epidemiology, classification, clinical presentations, diagnosis, and treatment of VMs. The aim of this consensus document is to provide recommendations for, and assist clinicians and patients in, the diagnosis and treatment of VMs.展开更多
The development of highly efficient electrocatalysts toward hydrogen oxidation reaction(HOR)under alkaline media is essential for the commercialization of alkaline exchange membrane fuel cells(AEMFCs).However,the HOR ...The development of highly efficient electrocatalysts toward hydrogen oxidation reaction(HOR)under alkaline media is essential for the commercialization of alkaline exchange membrane fuel cells(AEMFCs).However,the HOR kinetics in alkaline is two to three orders of magnitude slower than that in acid.More critically,fundamental understanding of the sluggish kinetics derived from the p H effect is still debatable.In this review,the recent development of understanding HOR mechanism and rational design of advanced HOR electrocatalysts are summarized.First,recent advances in the theories focusing on fundamental understandings of HOR under alkaline electrolyte are comprehensively discussed.Then,from the aspect of intermediates binding energy,optimizing hydrogen binding energy(HBE)and increasing hydroxyl binding energy(OHBE),the strategies for designing efficient alkaline HOR catalysts are summarized.At last,perspectives for the future research on alkaline HOR are pointed out.展开更多
This paper describes and illustrates a new species of Opalimosina Rohacek from Liaoning, Northeast China, namely Opalimosina(Opalimosina) verruca sp. nov., and provides a distribution map and a key to Chinese Opalimos...This paper describes and illustrates a new species of Opalimosina Rohacek from Liaoning, Northeast China, namely Opalimosina(Opalimosina) verruca sp. nov., and provides a distribution map and a key to Chinese Opalimosina. The genus Opalimosina is a new record for Liaoning, Northeast China.展开更多
One new species,Pseudocollinella(Spinotarsella)parahumida Su sp.nov.(Diptera:Sphaeroceridae),is described from Qinghai,China.Pseudocollinella(Spinotarsella)pseudohumida Papp,2016 is synonymized with P.(S.)humida(Halid...One new species,Pseudocollinella(Spinotarsella)parahumida Su sp.nov.(Diptera:Sphaeroceridae),is described from Qinghai,China.Pseudocollinella(Spinotarsella)pseudohumida Papp,2016 is synonymized with P.(S.)humida(Haliday,1836).A key to the species in the subgenus Spinotarsella is provided.展开更多
[Objective]The research aimed to analyze formation reason of " 0902" blizzard in northeast China. [Method]By using timely observation data,NCEP reanalysis data and Doppler radar data at Baishan station,blizzard proc...[Objective]The research aimed to analyze formation reason of " 0902" blizzard in northeast China. [Method]By using timely observation data,NCEP reanalysis data and Doppler radar data at Baishan station,blizzard process in southeast part of northeast China during 12-13 February,2009 was analyzed. [Result]Snowfall zone of the blizzard process was wide,snowfall was more,snowfall gradient was big,and snowfall time relatively concentrated. These characteristics reflected that the blizzard process had significant convection characteristics. Baroclinic disturbance at high-altitude straight frontal zone and ground warm frontogenesis caused by eastward movement and northward advancement of North China low vortex at low altitude were the circulation characteristics in the process. Water vapor from the sea went northward as southwest airflow,and strongly converged in blizzard zone,which provided sufficient water vapor condition for the blizzard. Before heavy snowfall occurred,there was accumulation process of heat and energy. Conditional symmetric instability was main unstable mechanism of the blizzard. During heavy snowfall period,ascending branch of secondary vertical circulation at exit zone of high-altitude jet coupled with ascending branch of secondary vertical circulation of warm frontegenesis at low layer,inducing strong development of the vertical motion. Doppler radar intensity echo revealed that it was easy to generate blizzard in the area where echo intensity was consistently above 20 dBz. Strong wind velocity convergence zone at radical velocity field especially adverse wind zone was favorable for the generation of blizzard. [Conclusion]The research could provide reference for blizzard forecast in northeast China.展开更多
Flexible aqueous zinc-ion batteries(AZIBs)with air-recharging capability are a promising self-powered system applied in future wearable electronics.It is desired to develop high-capacity air-rechargeable AZIBs.Herein,...Flexible aqueous zinc-ion batteries(AZIBs)with air-recharging capability are a promising self-powered system applied in future wearable electronics.It is desired to develop high-capacity air-rechargeable AZIBs.Herein,we developed a flexible AZIB with air-recharging capability based on trinitrohexaazatrinaphthylene(TNHATN)cathode and a ZnSO_(4)electrolyte.The flexible Zn//TNHATN battery exhibits high volumetric energy density(21.36 mWh/cm^3)and excellent mechanical flexibility.Impressing,the discharged flexible Zn//TNHATN battery can be chemical self-charged via the redox reaction between TNHATN cathode and O_(2)from the air.After oxidation in air for 15 h,such flexible Zn//TNHATN battery can deliver a high specific capacity of 320 mAh/g at 0.5 A/g,displaying excellent air-recharging capability.Notably,this flexible Zn//TNHATN battery also works well in chemical or/and galvanostatic charging mixed modes,showing reusability.This work provides a new insight for designing flexible aqueous self-powered systems.展开更多
Background:The molecular mechanisms driving tumorigenesis have continually been the focus of researchers.Cuproplasia is defined as copper-dependent cell growth and proliferation,including its primary and secondary rol...Background:The molecular mechanisms driving tumorigenesis have continually been the focus of researchers.Cuproplasia is defined as copper-dependent cell growth and proliferation,including its primary and secondary roles in tumor formation and proliferation through signaling pathways.In this study,we analyzed the differences in the expression of cuproplasia-associated genes(CAGs)in pan-cancerous tissues and investigated their role in immune-regulation and tumor prognostication.Methods:Raw data from 11,057 cancer samples were acquired from multiple databases.Pan-cancer analysis was conducted to analyze the CAG expression,single-nucleotide variants,copy number variants,methylation signatures,and genomic signatures of micro RNA(miRNA)-messenger RNA(mRNA)interactions.The Genomics of Drug Sensitivity in Cancer and the Cancer Therapeutics Response Portal databases were used to evaluate drug sensitivity and resistance against CAGs.Using single-sample Gene Set Enrichment Analysis(ssGSEA)and Immune Cell Abundance Identifier database,immune cell infiltration was analyzed with the ssGSEA score as the standard.Results:Aberrantly expressed CAGs were found in multiple cancers.The frequency of single-nucleotide variations in CAGs ranged from 1%to 54%among different cancers.Furthermore,the correlation between CAG expression in the tumor microenvironment and immune cell infiltration varied among different cancers.ATP7A and ATP7B were negatively correlated with macrophages in 16 tumors including breast invasive carcinoma and esophageal carcinoma,while the converse was true for MT1A and MT2A.In addition,we established cuproplasia scores and demonstrated their strong correlation with patient prognosis,immunotherapy responsiveness,and disease progression(P<0.05).Finally,we identified potential candidate drugs by matching gene targets with existing drugs.Conclusions:This study reports the genomic characterization and clinical features of CAGs in pan-cancers.It helps clarify the relationship between CAGs and tumorigenesis,and may be helpful in the development of biomarkers and new therapeutic agents.展开更多
The kinetics of hydrogen oxidation reaction(HOR)declines with orders of magnitude when the electrolyte varies from acid to base.Therefore,unveiling the mechanism of pH-dependent HOR and narrowing the acid-base kinetic...The kinetics of hydrogen oxidation reaction(HOR)declines with orders of magnitude when the electrolyte varies from acid to base.Therefore,unveiling the mechanism of pH-dependent HOR and narrowing the acid-base kinetic gap are indispensable and challenging.Here,the HOR behaviors of palladium phosphides and their counterpart(PdP_2/C,Pd_5P_2/C,Pd_3P/C,and Pd/C)in the whole pH region(from pH 1 to 13)are explored.Unexpectedly,there are non-monotonous relationships between their HOR kinetics and varied pHs,showing distinct inflection-point behaviors(inflection points and acid-base kinetic gaps).We find the inflection-point behaviors can be explained by the discrepant role of pH-dependent hydroxyl binding energy(OHBE)and hydrogen binding energy(HBE)induced HOR kinetics under the entire pH range.We further reveal that the strengthened OHBE is responsible for the earlier appearance of the inflection point and much narrower acid-base kinetic gap.These findings are conducive to understanding the mechanism of the pH-targeted HOR process,and provide a new strategy for rational designing advanced HOR electrocatalysts under alkaline electrolyte.展开更多
Exploring efficient and economical electrocatalysts and understanding the mechanism for alkaline hydrogen oxidation reaction(HOR)are crucial to facilitate the development of alkaline polymer electrolyte fuel cells(APE...Exploring efficient and economical electrocatalysts and understanding the mechanism for alkaline hydrogen oxidation reaction(HOR)are crucial to facilitate the development of alkaline polymer electrolyte fuel cells(APEFCs).Herein,Ru_(2)P was synthesized and used as an anodic HOR electrocatalyst for APEFC,achieving a peak power density of 1.3 W cm^(−2),the highest value among Pt-free anode electrocatalysts reported under the same conditions.Fromthe density functional theory(DFT)calculations and experimental results,it was found that besides the optimized hydrogen binding energy,the enhanced adsorption strength of oxygenated species(OH*)and the reduced work function of Ru_(2)P contributed to the enhanced HOR performance.The normalized exchange current densities of Ru_(2)P/C were 0.37 mA cm_(ECSA)^(−2) and 0.27 mAμgRu^(−1),respectively,both approximately three times higher than those of Ru when conducted in the rotating disk electrode(RDE)system.Our work provides a new pathway for exploring highly active Pt-free HOR electrocatalysts and expanding the family of anodic electrocatalysts for APEFCs.展开更多
文摘In China, meteorological forecasting relies on meteorological data obtained from regional and national stations. However, there were discrepancies between the data collected from the meteorological station at the passion fruit growing base and the data from regional and national stations. Consequently, the high and low temperature disaster indicators determined by the meteorological station at the passion fruit growing base cannot be applied to meteorological forecasting. To address this issue and facilitate the monitoring and early warning of high and low temperature disasters in passion fruit cultivation in Fujian, China, we used multi-source hourly temperature data (including the data from meteorological observation stations in passion fruit growing bases, the nearest regional stations, and national surface conventional meteorological observation stations) in three cities in southwestern Fujian (Longyan, Sanming, and Zhangzhou) spanning the years 2020 to 2022. By employing comprehensive statistical analysis methods (0.5 interval division and Cumulative frequency), we identified that passion fruit in southwestern Fujian was susceptible to high temperature disasters during the blooming-fruiting period, as well as low temperature disasters during the sprouting period. Consequently, we developed high and low temperature disaster indicators based on data from regional and national stations for different phenological periods of passion fruit in this region.
基金supported by grant from the National Natural Science Foundation of China,China(No.81871458)
文摘Venous malformations(VMs) are the most common vascular developmental anomalies. There are many controversies over VMs in Chinese clinical medical practice. Experts on the panel from vascular-anomaly centers in China reviewed the etiology, pathophysiology, epidemiology, classification, clinical presentations, diagnosis, and treatment of VMs. The aim of this consensus document is to provide recommendations for, and assist clinicians and patients in, the diagnosis and treatment of VMs.
基金partly supported by the Natural Science Foundation of Liaoning Province(20170540642)the General Project of Scientific Research of the Education Department of Liaoning Province(L2015359)the Key Project of the Qinghai Qilian Mountain Nature Reserve Administration(QHTX-2021-006)。
基金financially supported by the National Key Research and Development program of China(2018YFB1502302)the National Natural Science Foundation of China(21972107)+1 种基金the Natural Science Foundation of Hubei Province(2020CFA095)the Natural Science Foundation of Jiangsu Province(BK20191186)。
文摘The development of highly efficient electrocatalysts toward hydrogen oxidation reaction(HOR)under alkaline media is essential for the commercialization of alkaline exchange membrane fuel cells(AEMFCs).However,the HOR kinetics in alkaline is two to three orders of magnitude slower than that in acid.More critically,fundamental understanding of the sluggish kinetics derived from the p H effect is still debatable.In this review,the recent development of understanding HOR mechanism and rational design of advanced HOR electrocatalysts are summarized.First,recent advances in the theories focusing on fundamental understandings of HOR under alkaline electrolyte are comprehensively discussed.Then,from the aspect of intermediates binding energy,optimizing hydrogen binding energy(HBE)and increasing hydroxyl binding energy(OHBE),the strategies for designing efficient alkaline HOR catalysts are summarized.At last,perspectives for the future research on alkaline HOR are pointed out.
基金partly supported by the National Natural Science Foundation of China (31772541)the Natural Science Foundation of Liaoning Province (20170540642)the General Project of Scientific Research of the Education Department of Liaoning Province (L2015359)
文摘This paper describes and illustrates a new species of Opalimosina Rohacek from Liaoning, Northeast China, namely Opalimosina(Opalimosina) verruca sp. nov., and provides a distribution map and a key to Chinese Opalimosina. The genus Opalimosina is a new record for Liaoning, Northeast China.
基金supported by the National Natural Science Foundation of China(31772541)the Natural Science Foundation of Liaoning Province(20170540642)+1 种基金the General Project of Scientific Research of the Education Department of Liaoning Province(L2015359)the Key Project of the Qinghai Qilian Mountain Nature Reserve Administration(QHTX-2021-006)。
文摘One new species,Pseudocollinella(Spinotarsella)parahumida Su sp.nov.(Diptera:Sphaeroceridae),is described from Qinghai,China.Pseudocollinella(Spinotarsella)pseudohumida Papp,2016 is synonymized with P.(S.)humida(Haliday,1836).A key to the species in the subgenus Spinotarsella is provided.
文摘[Objective]The research aimed to analyze formation reason of " 0902" blizzard in northeast China. [Method]By using timely observation data,NCEP reanalysis data and Doppler radar data at Baishan station,blizzard process in southeast part of northeast China during 12-13 February,2009 was analyzed. [Result]Snowfall zone of the blizzard process was wide,snowfall was more,snowfall gradient was big,and snowfall time relatively concentrated. These characteristics reflected that the blizzard process had significant convection characteristics. Baroclinic disturbance at high-altitude straight frontal zone and ground warm frontogenesis caused by eastward movement and northward advancement of North China low vortex at low altitude were the circulation characteristics in the process. Water vapor from the sea went northward as southwest airflow,and strongly converged in blizzard zone,which provided sufficient water vapor condition for the blizzard. Before heavy snowfall occurred,there was accumulation process of heat and energy. Conditional symmetric instability was main unstable mechanism of the blizzard. During heavy snowfall period,ascending branch of secondary vertical circulation at exit zone of high-altitude jet coupled with ascending branch of secondary vertical circulation of warm frontegenesis at low layer,inducing strong development of the vertical motion. Doppler radar intensity echo revealed that it was easy to generate blizzard in the area where echo intensity was consistently above 20 dBz. Strong wind velocity convergence zone at radical velocity field especially adverse wind zone was favorable for the generation of blizzard. [Conclusion]The research could provide reference for blizzard forecast in northeast China.
基金supported by the National Natural Science Foundation of China(No.21975034)the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutionsthe Research Project of State Key Laboratory of Coordination Chemistry。
文摘Flexible aqueous zinc-ion batteries(AZIBs)with air-recharging capability are a promising self-powered system applied in future wearable electronics.It is desired to develop high-capacity air-rechargeable AZIBs.Herein,we developed a flexible AZIB with air-recharging capability based on trinitrohexaazatrinaphthylene(TNHATN)cathode and a ZnSO_(4)electrolyte.The flexible Zn//TNHATN battery exhibits high volumetric energy density(21.36 mWh/cm^3)and excellent mechanical flexibility.Impressing,the discharged flexible Zn//TNHATN battery can be chemical self-charged via the redox reaction between TNHATN cathode and O_(2)from the air.After oxidation in air for 15 h,such flexible Zn//TNHATN battery can deliver a high specific capacity of 320 mAh/g at 0.5 A/g,displaying excellent air-recharging capability.Notably,this flexible Zn//TNHATN battery also works well in chemical or/and galvanostatic charging mixed modes,showing reusability.This work provides a new insight for designing flexible aqueous self-powered systems.
文摘Background:The molecular mechanisms driving tumorigenesis have continually been the focus of researchers.Cuproplasia is defined as copper-dependent cell growth and proliferation,including its primary and secondary roles in tumor formation and proliferation through signaling pathways.In this study,we analyzed the differences in the expression of cuproplasia-associated genes(CAGs)in pan-cancerous tissues and investigated their role in immune-regulation and tumor prognostication.Methods:Raw data from 11,057 cancer samples were acquired from multiple databases.Pan-cancer analysis was conducted to analyze the CAG expression,single-nucleotide variants,copy number variants,methylation signatures,and genomic signatures of micro RNA(miRNA)-messenger RNA(mRNA)interactions.The Genomics of Drug Sensitivity in Cancer and the Cancer Therapeutics Response Portal databases were used to evaluate drug sensitivity and resistance against CAGs.Using single-sample Gene Set Enrichment Analysis(ssGSEA)and Immune Cell Abundance Identifier database,immune cell infiltration was analyzed with the ssGSEA score as the standard.Results:Aberrantly expressed CAGs were found in multiple cancers.The frequency of single-nucleotide variations in CAGs ranged from 1%to 54%among different cancers.Furthermore,the correlation between CAG expression in the tumor microenvironment and immune cell infiltration varied among different cancers.ATP7A and ATP7B were negatively correlated with macrophages in 16 tumors including breast invasive carcinoma and esophageal carcinoma,while the converse was true for MT1A and MT2A.In addition,we established cuproplasia scores and demonstrated their strong correlation with patient prognosis,immunotherapy responsiveness,and disease progression(P<0.05).Finally,we identified potential candidate drugs by matching gene targets with existing drugs.Conclusions:This study reports the genomic characterization and clinical features of CAGs in pan-cancers.It helps clarify the relationship between CAGs and tumorigenesis,and may be helpful in the development of biomarkers and new therapeutic agents.
基金supported by the National Key Research and Development Program of China(2021YFB4001200)the National Natural Science Foundation of China(22272121,21972107)the Natural Science Foundation of Hubei Province(2020CFA095)。
文摘The kinetics of hydrogen oxidation reaction(HOR)declines with orders of magnitude when the electrolyte varies from acid to base.Therefore,unveiling the mechanism of pH-dependent HOR and narrowing the acid-base kinetic gap are indispensable and challenging.Here,the HOR behaviors of palladium phosphides and their counterpart(PdP_2/C,Pd_5P_2/C,Pd_3P/C,and Pd/C)in the whole pH region(from pH 1 to 13)are explored.Unexpectedly,there are non-monotonous relationships between their HOR kinetics and varied pHs,showing distinct inflection-point behaviors(inflection points and acid-base kinetic gaps).We find the inflection-point behaviors can be explained by the discrepant role of pH-dependent hydroxyl binding energy(OHBE)and hydrogen binding energy(HBE)induced HOR kinetics under the entire pH range.We further reveal that the strengthened OHBE is responsible for the earlier appearance of the inflection point and much narrower acid-base kinetic gap.These findings are conducive to understanding the mechanism of the pH-targeted HOR process,and provide a new strategy for rational designing advanced HOR electrocatalysts under alkaline electrolyte.
基金financially supported by the National Key Research and Development Program of China(no.2018YFB1502302)the National Natural Science Foundation of China(nos.21972107,21832004,21633008,and 51872115)+1 种基金the National Natural Science Foundation of Jiangsu Province(no.BK20191186)the National Natural Science Foundation of Hubei Province(no.2020CFA095).
文摘Exploring efficient and economical electrocatalysts and understanding the mechanism for alkaline hydrogen oxidation reaction(HOR)are crucial to facilitate the development of alkaline polymer electrolyte fuel cells(APEFCs).Herein,Ru_(2)P was synthesized and used as an anodic HOR electrocatalyst for APEFC,achieving a peak power density of 1.3 W cm^(−2),the highest value among Pt-free anode electrocatalysts reported under the same conditions.Fromthe density functional theory(DFT)calculations and experimental results,it was found that besides the optimized hydrogen binding energy,the enhanced adsorption strength of oxygenated species(OH*)and the reduced work function of Ru_(2)P contributed to the enhanced HOR performance.The normalized exchange current densities of Ru_(2)P/C were 0.37 mA cm_(ECSA)^(−2) and 0.27 mAμgRu^(−1),respectively,both approximately three times higher than those of Ru when conducted in the rotating disk electrode(RDE)system.Our work provides a new pathway for exploring highly active Pt-free HOR electrocatalysts and expanding the family of anodic electrocatalysts for APEFCs.