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IgG N-糖基心血管年龄独立于真实年龄精准表征心血管事件风险
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作者 武志远 郭政 +9 位作者 郑雨露 王玉涛 张海平 潘慧颖 李志伟 Lois Balmer 李霞 陶丽新 郭秀花 王嵬 《Engineering》 SCIE EI CAS CSCD 2023年第7期99-107,I0004,I0005,共11页
亚临床动脉粥样硬化和代谢紊乱是心血管健康的重要风险因素,应用免疫球蛋白G(IgG)N-聚糖模式作为炎症指标表征其发病风险已有研究报道。然而,对于IgG N-糖基谱在心血管疾病(CVD)风险分层中的能力仍然未知。本研究旨在利用IgG N-糖基标... 亚临床动脉粥样硬化和代谢紊乱是心血管健康的重要风险因素,应用免疫球蛋白G(IgG)N-聚糖模式作为炎症指标表征其发病风险已有研究报道。然而,对于IgG N-糖基谱在心血管疾病(CVD)风险分层中的能力仍然未知。本研究旨在利用IgG N-糖基标志物开发追踪心血管疾病风险的年龄指数。本研究基于横断面调查,从Busselton健康和老龄研究中共招募1465名40~70岁之间的个体。使用机器学习递归特征消除和惩罚回归算法逐步筛选特征糖基,并开发IgG N-糖基化心血管年龄(GlyCage)指数,以反映归因于心血管风险的与真实年龄间的偏差。结果显示,对GlyCage指数贡献最大的是具有双分叉N-乙酰葡萄糖胺(GlcNAc)的岩藻糖基化N-聚糖(GP6,FA2B)和具有双分叉GlcNAc的双半乳糖基化N-聚糖(GP13,A2BG2)。GlyCage独立于真实年龄,与较高的Framingham十年心血管风险[优势比(OR)为1.09;95%CI:1.05~1.13]和患心血管疾病概率(OR,1.07;95%CI:1.01~1.13)显著相关。GlyCage大于真实年龄三年及以上的个体,其心血管风险和心血管疾病患病概率增加,调整后的OR值分别为2.22(95%CI:1.41~3.53)和2.71(95%CI:1.25~6.41)。GlyCage指数区分十年心血管风险和事件的ROC曲线下面积(AUC)值分别为0.73和0.65,而真实年龄为0.65和0.63。因此,本研究开发的GlyCage指数利用IgG N-糖基谱追踪心血管健康水平。GlyCage和真实年龄之间的差距能够独立地表征心血管风险,提示IgG N-糖基化在心血管疾病的发病机制中起作用。GlyCage指数对心血管风险的预测能力需要在其他人群中进行外部和纵向验证。 展开更多
关键词 IgG N-glycosylation cardiovascular age Cardiovascular aging Immunoglobulin G GLYCOSYLATION Inflammation Feature selection Machine learning
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An Ontology-based Ranking Model in Search Engines
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作者 Yu Hou lixin tao 《Journal of Computer Science Research》 2019年第2期8-16,共9页
As the tsunami of data has emerged,search engines have become the most powerful tool for obtaining scattered information on the internet.The traditional search engines return the organized results by using ranking alg... As the tsunami of data has emerged,search engines have become the most powerful tool for obtaining scattered information on the internet.The traditional search engines return the organized results by using ranking algorithm such as term frequency,link analysis(PageRank algorithm and HITS algorithm)etc.However,these algorithms must combine the keyword frequency to determine the relevance between user’s query and the data in the computer system or internet.Moreover,we expect the search engines could understand users’searching by content meanings rather than literal strings.Semantic Web is an intelligent network and it could understand human’s language more semantically and make the communication easier between human and computers.But,the current technology for the semantic search is hard to apply.Because some meta data should be annotated to each web pages,then the search engine will have the ability to understand the users intend.However,annotate every web page is very time-consuming and leads to inefficiency.So,this study designed an ontology-based approach to improve the current traditional keyword-based search and emulate the effects of semantic search.And let the search engine can understand users more semantically when it gets the knowledge. 展开更多
关键词 Search engine Knowledge representation ONTOLOGY Semantic similarity Page ranking
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Mobile Software Assurance Informed through Knowledge Graph Construction: The OWASP Threat of Insecure Data Storage
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作者 Suzanna Schmeelk lixin tao 《Journal of Computer Science Research》 2020年第2期17-29,共13页
Many organizations,to save costs,are moving to the Bring Your Own Mobile Device(BYOD)model and adopting applications built by third-parties at an unprecedented rate.Our research examines software assurance methodologi... Many organizations,to save costs,are moving to the Bring Your Own Mobile Device(BYOD)model and adopting applications built by third-parties at an unprecedented rate.Our research examines software assurance methodologies specifically focusing on security analysis coverage of the program analysis for mobile malware detection,mitigation,and prevention.This research focuses on secure software development of Android applications by developing knowledge graphs for threats reported by the Open Web Application Security Project(OWASP).OWASP maintains lists of the top ten security threats to web and mobile applications.We develop knowledge graphs based on the two most recent top ten threat years and show how the knowledge graph relationships can be discovered in mobile application source code.We analyze 200+healthcare applications from GitHub to gain an understanding of their software assurance of their developed software for one of the OWASP top ten mobile threats,the threat of“Insecure Data Storage.”We find that many of the applications are storing personally identifying information(PII)in potentially vulnerable places leaving users exposed to higher risks for the loss of their sensitive data. 展开更多
关键词 CYBERSECURITY Secure software development Penetration testing Risk assessment
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A Case Study of Mobile Health Applications:The OWASP Risk of Insufficient Cryptography
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作者 Suzanna Schmeelk lixin tao 《Journal of Computer Science Research》 2022年第1期22-31,共10页
Mobile devices are being deployed rapidly for both private and professional reasons.One area of that has been growing is in releasing healthcare applications into the mobile marketplaces for health management.These ap... Mobile devices are being deployed rapidly for both private and professional reasons.One area of that has been growing is in releasing healthcare applications into the mobile marketplaces for health management.These applications help individuals track their own biorhythms and contain sensitive information.This case study examines the source code of mobile applications released to GitHub for the Risk of Insufficient Cryptography in the Top Ten Mobile Open Web Application Security Project risks.We first develop and justify a mobile OWASP Cryptographic knowledge-graph for detecting security weaknesses specific to mobile applications which can be extended to other domains involving cryptography.We then analyze the source code of 203 open source healthcare mobile applications and report on their usage of cryptography in the applications.Our findings show that none of the open source healthcare applications correctly applied cryptography in all elements of their applications.As humans adopt healthcare applications for managing their health routines,it is essential that they consider the privacy and security risks they are accepting when sharing their data.Furthermore,many open source applications and developers have certain environmental parameters which do not mandate adherence to regulations.In addition to creating new free tools for security risk identifications during software development such as standalone or compiler-embedded,the article suggests awareness and training modules for developers prior to marketplace software release. 展开更多
关键词 OWASP mobile threats CRYPTOGRAPHY Mobile application MHEALTH Healthcare ANDROID
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Long-term exposure to air pollution and cerebrovascular disease:findings from Beijing Health Management Cohort study 被引量:1
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作者 Yuhan Zhao Xiaoping Kang +9 位作者 Xue Tian Lulu Liu Zemeng Zhao Lili Luo lixin tao Xiangtong Liu Xiaonan Wang Xiuhua Guo Juan Xia Yanxia Luo 《Frontiers of Environmental Science & Engineering》 SCIE EI CSCD 2023年第7期79-89,共11页
The relationship between air pollution and cerebrovascular disease has become a popular topic,yet research findings are highly heterogeneous.This study aims to investigate this association based on detailed individual... The relationship between air pollution and cerebrovascular disease has become a popular topic,yet research findings are highly heterogeneous.This study aims to investigate this association based on detailed individual health data and a precise evaluation of their exposure levels.The integrated models of generalized additive model,land use regression model and back propagation neural network were used to evaluate the exposure concentrations.And doubly robust additive model was conducted to explore the association between cerebrovascular disease and air pollution after adjusted for demographic characteristics,physical examination,disease information,geographic and socioeconomic status.A total of 25097 subjects were included in the Beijing Health Management Cohort from 2013 to 2018.With a 1µg/m^(3)increase in the concentrations of PM_(2.5),SO_(2)and NO_(2),the incidence risk of cerebrovascular disease increased by 1.02(95%CI:1.008–1.034),1.06(95%CI:1.034–1.095)and 1.02(95%CI:1.010–1.029)respectively.Whereas CO exposure could decrease the risk,with an odds ratio of 0.38(95%CI:0.212–0.626).In the subgroup analysis,individuals under the age of 50 with normal BMI were at higher risk caused by PM2.5,and So2 was considered more hazardous to women.Meanwhile,the protective effect of CO on women and those with normal BMI was stronger.Successful reduction of long-term exposure to PM2.5,SO_(2)and NO_(2)would lead to substantial benefits for decrease the risk of cerebrovascular disease especially for the health of the susceptible individuals. 展开更多
关键词 Air pollution Cerebrovascular disease INCIDENCE Long-term exposure Doubly robust additive model
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