Recently,multifunctional nanoparticles have shown great prospects in cancer treatment,which have the ability to simultaneously deliver the drug,image and target tumor cells.In this paper,we designed a luminescent nano...Recently,multifunctional nanoparticles have shown great prospects in cancer treatment,which have the ability to simultaneously deliver the drug,image and target tumor cells.In this paper,we designed a luminescent nanoparticles platform based on hydrothermal hyaluronic acid/amorphous calcium phosphate(HA-FCNs/ACP)with multifunctional properties for drug delivery,bio-imaging,and targeting treatment.HA-FCNs/ACP shows an ability to load curcumin(Cur)with pH-sensitive responsive drug release behavior and excellent biocompatibility.HA-FCNs/ACP dispersed in the cytoplasm through the overexpressed CD44 receptor that is actively targeted into human lung cancer cells(A549 cells).Meanwhile,the viability of A549 cells was significantly inhibited in vitro.The prepared HA-FCNs and HA-FCNs/ACP both exhibit excellent targeted bioimaging performance on cancer cells.Hence,the as-prepared nanoparticles have promising applications in treating tumor disease.展开更多
Alzheimer’s disease(AD)is a prevalent neurodegenerative disease in the aged population1.Etiology of AD remains largely unknown and no effective drugs are available in clinical settings to reverse or delay the disease...Alzheimer’s disease(AD)is a prevalent neurodegenerative disease in the aged population1.Etiology of AD remains largely unknown and no effective drugs are available in clinical settings to reverse or delay the disease progress2.In recent years,the brain’s lymphatic systems,including glymphatic3 that exists in the brain interstitial space and meningeal lymphatic vessels4 that presents within the dural sinuses,have been found to play an important role in the AD pathogenesis.展开更多
基金financially supported by the National Natural Science Foundation of China (31700689)Natural Science Foundation of Shanxi Province (201901D111115)+1 种基金Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi (172040098-S)Transformation of Scientific and Technological Achievements Programs of Higher Education Institutions in Shanxi (2020CG015)
文摘Recently,multifunctional nanoparticles have shown great prospects in cancer treatment,which have the ability to simultaneously deliver the drug,image and target tumor cells.In this paper,we designed a luminescent nanoparticles platform based on hydrothermal hyaluronic acid/amorphous calcium phosphate(HA-FCNs/ACP)with multifunctional properties for drug delivery,bio-imaging,and targeting treatment.HA-FCNs/ACP shows an ability to load curcumin(Cur)with pH-sensitive responsive drug release behavior and excellent biocompatibility.HA-FCNs/ACP dispersed in the cytoplasm through the overexpressed CD44 receptor that is actively targeted into human lung cancer cells(A549 cells).Meanwhile,the viability of A549 cells was significantly inhibited in vitro.The prepared HA-FCNs and HA-FCNs/ACP both exhibit excellent targeted bioimaging performance on cancer cells.Hence,the as-prepared nanoparticles have promising applications in treating tumor disease.
基金supported by a project(32271220)from the National Natural Science Foundation of China to Jianping Ye.
文摘Alzheimer’s disease(AD)is a prevalent neurodegenerative disease in the aged population1.Etiology of AD remains largely unknown and no effective drugs are available in clinical settings to reverse or delay the disease progress2.In recent years,the brain’s lymphatic systems,including glymphatic3 that exists in the brain interstitial space and meningeal lymphatic vessels4 that presents within the dural sinuses,have been found to play an important role in the AD pathogenesis.
