The emerging resistance to schistosoma has been paid much attention and is in urgent need for a novel strategy to control the prevalent parasitic zoonosis. In this study, the efficiency of hyperthermia therapy was inv...The emerging resistance to schistosoma has been paid much attention and is in urgent need for a novel strategy to control the prevalent parasitic zoonosis. In this study, the efficiency of hyperthermia therapy was investigated by the skin hyperthermia device. The survival rate of cercariae decreased from 68.15 %(37 °C, 5 min) to 0(49 °C, 10 min) with the thermal dosages increased, which proved the preventing effect of hyperthermia therapy(P \ 0.05). Therapeutic effects were assessed in Schistosoma japonicum-infected BALB/c mice. When the cercarial contact region of the skin was treated at 45–49 °C for5 min within 8 h of infection, worm reduction rate(WRR)reached 74 %–83 %(P \ 0.01). The sensitivity of adultschistosoma to heat was also investigated using microwave intraperitoneal hyperthermia(thermal dosages 42–43 °C,20 min). The WRR, hepatic shift rates and egg reduction rates were 23.7 %, 40 % and 30 %, respectively, comparing with 80.2 %, 59.6 % and 53.9 % of praziquantel(PZQ)-treated group. Encouraging results have been obtained that hyperthermia can effectively kill schistosomula, especially with the appearance of cercarial dermatitis, while PZQ lacks efficacy against the cercariae. Thus,hyperthermia therapy would show significant benefit in preventing and treatment of schistosoma, especially in the early stage.展开更多
A novel method called the general waterfilling,which is suitable when clutter is not negligible,is proposed to solve the waveform design problem of broadband radar for the recognition of multiple extended targets.The ...A novel method called the general waterfilling,which is suitable when clutter is not negligible,is proposed to solve the waveform design problem of broadband radar for the recognition of multiple extended targets.The uncertainty of the target’s radar signatures is decreased via maximizing the mutual information between a random extended target and the received signal.Then,the general water-filling method is employed to the waveform design problem for multiple extended targets identification to increase the separability of multiple targets.Experimental results evaluated the efficiency of the proposed method.Compared to chirp signal and water-filling signal,our method improves the classification rates and even performs better at low signal-to-interference-plus-noise ratio(SINR).展开更多
基金supported by the Bill & Melinda Gates Foundation(Grant No.1024516)
文摘The emerging resistance to schistosoma has been paid much attention and is in urgent need for a novel strategy to control the prevalent parasitic zoonosis. In this study, the efficiency of hyperthermia therapy was investigated by the skin hyperthermia device. The survival rate of cercariae decreased from 68.15 %(37 °C, 5 min) to 0(49 °C, 10 min) with the thermal dosages increased, which proved the preventing effect of hyperthermia therapy(P \ 0.05). Therapeutic effects were assessed in Schistosoma japonicum-infected BALB/c mice. When the cercarial contact region of the skin was treated at 45–49 °C for5 min within 8 h of infection, worm reduction rate(WRR)reached 74 %–83 %(P \ 0.01). The sensitivity of adultschistosoma to heat was also investigated using microwave intraperitoneal hyperthermia(thermal dosages 42–43 °C,20 min). The WRR, hepatic shift rates and egg reduction rates were 23.7 %, 40 % and 30 %, respectively, comparing with 80.2 %, 59.6 % and 53.9 % of praziquantel(PZQ)-treated group. Encouraging results have been obtained that hyperthermia can effectively kill schistosomula, especially with the appearance of cercarial dermatitis, while PZQ lacks efficacy against the cercariae. Thus,hyperthermia therapy would show significant benefit in preventing and treatment of schistosoma, especially in the early stage.
文摘A novel method called the general waterfilling,which is suitable when clutter is not negligible,is proposed to solve the waveform design problem of broadband radar for the recognition of multiple extended targets.The uncertainty of the target’s radar signatures is decreased via maximizing the mutual information between a random extended target and the received signal.Then,the general water-filling method is employed to the waveform design problem for multiple extended targets identification to increase the separability of multiple targets.Experimental results evaluated the efficiency of the proposed method.Compared to chirp signal and water-filling signal,our method improves the classification rates and even performs better at low signal-to-interference-plus-noise ratio(SINR).
