The N-methyl-d-aspartate(NMDA)receptors,which belong to the ionotropic Glutamate receptors,constitute a family of ligand-gated ion channels.Within the various subtypes of NMDA receptors,the GluN1/2A subtype plays a si...The N-methyl-d-aspartate(NMDA)receptors,which belong to the ionotropic Glutamate receptors,constitute a family of ligand-gated ion channels.Within the various subtypes of NMDA receptors,the GluN1/2A subtype plays a significant role in central nervous system(CNS)disorders.The present article aims to provide a comprehensive review of ligands targeting GluN2A-containing NMDA receptors,encompassing negative allosteric modulators(NAMs),positive allosteric modulators(PAMs)and competitive antagonists.Moreover,the ligands’structure–activity relationships(SARs)and the binding models of representative ligands are also discussed,providing valuable insights for the clinical rational design of effective drugs targeting CNS diseases.展开更多
The fission yield data in the 14 MeV energy neutron induced fission of^(238)U play an important role in decay heat calculations and generation-Ⅳ reactor designs.In order to accurately measure fission product yields(F...The fission yield data in the 14 MeV energy neutron induced fission of^(238)U play an important role in decay heat calculations and generation-Ⅳ reactor designs.In order to accurately measure fission product yields(FPYs)of^(238)U induced by 14 MeV neutrons,the cumulative yields of fission products ranging from^(92)Sr to^(147)Nd in the^(239)U(n,f) reaction with a 14.7 MeV neutron were determined using an off-line γ-ray spectrometric technique.The14.7 MeV quasi-monoenergetic neutron beam was provided by the K-400 D-T neutron generator at China Academy of Engineering Physics(CAEP).Fission products were measured by a low background high purity germanium gamma spectrometer.The neutron flux was obtained from the^(93)Nb(n.2n)^(92m)Nb reaction,and the mean neutron energy was calculated using the cross-section ratios for the^(90)Zr(n,2n)^(89)Zr and^(93)Nb(n,2n)^(92m)Nb reactions.With a series of corrections,high precision cumulative yields of 20 fission products were obtained.Our FPYs for the^(238)U(n,f) reaction at 14.7 MeV were compared with the existing experimental nuclear reaction data and evaluated nuclear data,respectively.The results will be helpful in the design of a generation-Ⅳ reactor and the construction of evaluated fission yield databases.展开更多
Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to dire...Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given.展开更多
基金The work was supported by the National Natural Science Foundation of China(82204200)the International Postdoctoral Exchange Fellowship Program(Talent-Introduction Program,YJ20210279,China)+1 种基金the China Postdoctoral Science Foundation(2022M711939)to Fabao Zhao,and the Natural Science Foundation of Shandong Province(ZR2022QH287 to Fabao Zhao and ZR2022QH312 to Na Liu,China).
文摘The N-methyl-d-aspartate(NMDA)receptors,which belong to the ionotropic Glutamate receptors,constitute a family of ligand-gated ion channels.Within the various subtypes of NMDA receptors,the GluN1/2A subtype plays a significant role in central nervous system(CNS)disorders.The present article aims to provide a comprehensive review of ligands targeting GluN2A-containing NMDA receptors,encompassing negative allosteric modulators(NAMs),positive allosteric modulators(PAMs)and competitive antagonists.Moreover,the ligands’structure–activity relationships(SARs)and the binding models of representative ligands are also discussed,providing valuable insights for the clinical rational design of effective drugs targeting CNS diseases.
基金Supported by the National Natural Science Foundation of China (11975113)。
文摘The fission yield data in the 14 MeV energy neutron induced fission of^(238)U play an important role in decay heat calculations and generation-Ⅳ reactor designs.In order to accurately measure fission product yields(FPYs)of^(238)U induced by 14 MeV neutrons,the cumulative yields of fission products ranging from^(92)Sr to^(147)Nd in the^(239)U(n,f) reaction with a 14.7 MeV neutron were determined using an off-line γ-ray spectrometric technique.The14.7 MeV quasi-monoenergetic neutron beam was provided by the K-400 D-T neutron generator at China Academy of Engineering Physics(CAEP).Fission products were measured by a low background high purity germanium gamma spectrometer.The neutron flux was obtained from the^(93)Nb(n.2n)^(92m)Nb reaction,and the mean neutron energy was calculated using the cross-section ratios for the^(90)Zr(n,2n)^(89)Zr and^(93)Nb(n,2n)^(92m)Nb reactions.With a series of corrections,high precision cumulative yields of 20 fission products were obtained.Our FPYs for the^(238)U(n,f) reaction at 14.7 MeV were compared with the existing experimental nuclear reaction data and evaluated nuclear data,respectively.The results will be helpful in the design of a generation-Ⅳ reactor and the construction of evaluated fission yield databases.
基金supported by the National Natural Science Foundation of China(Grant Nos.11490560 and 11321064)the National Basic Research Program of China(Grant No.2013CB834406)
文摘Jinping Underground laboratory for Nuclear Astrophysics(JUNA) will take the advantage of the ultra-low background of CJPL lab and high current accelerator based on an ECR source and a highly sensitive detector to directly study for the first time a number of crucial reactions occurring at their relevant stellar energies during the evolution of hydrostatic stars. In its first phase, JUNA aims at the direct measurements of^(25)Mg(p,γ)^(26)Al,^(19)F(p,α)^(16)O,^(13)C(α,n)^(16)O and ^(12)C(α,γ)^(16)O reactions. The experimental setup,which includes an accelerator system with high stability and high intensity, a detector system, and a shielding material with low background, will be established during the above research. The current progress of JUNA will be given.
