A multi-step isothermal forging and subsequent multipass rolling was used to produce one kind of two phase titanium alloy plate with thickness of 2.2 mm. Tensile properties at ambient temperature and at two kinds of h...A multi-step isothermal forging and subsequent multipass rolling was used to produce one kind of two phase titanium alloy plate with thickness of 2.2 mm. Tensile properties at ambient temperature and at two kinds of high temperatures were investigated for the plate with submicrocrystalline (SMC) structure in present work. Microstructures and fractographies of the alloy plate before and after tensile tests were also observed by scanning electron microscope. The results indicated that the alloy possesses favorite integrated tensile properties at ambient temperature, the average UTS and elongation for the longitudinal sample is 1070 MPa and 20%, while which for the transverse sample is 1103 MPa and 15%. The tensile elongation of the alloy plate is as high as 1078% at 780°C with a primary strain rate of 1.7 × 10<sup>-3</sup> s<sup>-1</sup>. The microstructure is fine for the alloy plate solutioned at 700°C for 1 h, AC, and the grain size after tensile test is 2 μm and 3 μm for the longitudinal and transverse plates. Fractography for the as-annealed plate is composed of a large number of dimples and voids after tensile test at ambient temperature.展开更多
We report herein the design and synthesis of a series of novel fluoride-containing gossypol derivatives by the condensation reaction of gossypol with fluoride-containing aromatic amine. These fluoride-containing gossy...We report herein the design and synthesis of a series of novel fluoride-containing gossypol derivatives by the condensation reaction of gossypol with fluoride-containing aromatic amine. These fluoride-containing gossypol derivatives were characterized by IR, 1H-NMR and high resolution mass spectral data, then screened as antitumor agents against three human cancer cell lines (HeLa, A-549 and BGC-823) and a normal cell line (VEC) in vitro by using MTT cell proliferation assays. Results revealed that compounds 3a, 3c and 3f exhibited superior anticancer activity against HeLa, compounds 3b,3c, 3e and 3f exhibited superior anticancer activity against A-549, compounds 3b, 3c and 3f exhibited superior anticancer activity against BGC-823 compared to gossypol. In particular, fluorine substituent at the para positions of the phenyl ring showed remarkable inhibitory effects on HeLa?(3c: IC50 = 14.2 μM, 3f:?IC50 = 8.34 μM), A-549(3c: IC50 = 6.32 μM, 3f: IC50 = 9.76 μM) and BGC-823 cells?(3c: IC50 = 8.62 μM, 3f: IC50 = 4.36 μM). Furthermore, all the compounds 3a-3f exhibited lessened cytotoxicity against VEC compared to gossypol.展开更多
文摘A multi-step isothermal forging and subsequent multipass rolling was used to produce one kind of two phase titanium alloy plate with thickness of 2.2 mm. Tensile properties at ambient temperature and at two kinds of high temperatures were investigated for the plate with submicrocrystalline (SMC) structure in present work. Microstructures and fractographies of the alloy plate before and after tensile tests were also observed by scanning electron microscope. The results indicated that the alloy possesses favorite integrated tensile properties at ambient temperature, the average UTS and elongation for the longitudinal sample is 1070 MPa and 20%, while which for the transverse sample is 1103 MPa and 15%. The tensile elongation of the alloy plate is as high as 1078% at 780°C with a primary strain rate of 1.7 × 10<sup>-3</sup> s<sup>-1</sup>. The microstructure is fine for the alloy plate solutioned at 700°C for 1 h, AC, and the grain size after tensile test is 2 μm and 3 μm for the longitudinal and transverse plates. Fractography for the as-annealed plate is composed of a large number of dimples and voids after tensile test at ambient temperature.
文摘We report herein the design and synthesis of a series of novel fluoride-containing gossypol derivatives by the condensation reaction of gossypol with fluoride-containing aromatic amine. These fluoride-containing gossypol derivatives were characterized by IR, 1H-NMR and high resolution mass spectral data, then screened as antitumor agents against three human cancer cell lines (HeLa, A-549 and BGC-823) and a normal cell line (VEC) in vitro by using MTT cell proliferation assays. Results revealed that compounds 3a, 3c and 3f exhibited superior anticancer activity against HeLa, compounds 3b,3c, 3e and 3f exhibited superior anticancer activity against A-549, compounds 3b, 3c and 3f exhibited superior anticancer activity against BGC-823 compared to gossypol. In particular, fluorine substituent at the para positions of the phenyl ring showed remarkable inhibitory effects on HeLa?(3c: IC50 = 14.2 μM, 3f:?IC50 = 8.34 μM), A-549(3c: IC50 = 6.32 μM, 3f: IC50 = 9.76 μM) and BGC-823 cells?(3c: IC50 = 8.62 μM, 3f: IC50 = 4.36 μM). Furthermore, all the compounds 3a-3f exhibited lessened cytotoxicity against VEC compared to gossypol.
