Antimicrobial resistance(AMR)is one of the top global challenges of public health concern.In 2019,it was estimated that AMR claimed around 5 million deaths worldwide[1].Pseudomonas aeruginosa,which originated in soil ...Antimicrobial resistance(AMR)is one of the top global challenges of public health concern.In 2019,it was estimated that AMR claimed around 5 million deaths worldwide[1].Pseudomonas aeruginosa,which originated in soil and water,is recognized as an opportunistic pathogen causing recalcitrant infections.Carbapenem-resistant P.aeruginosa(CRPA)is listed by the World Health Organization(WHO)as an important member of top priority“ESKAPE”pathogens.This is largely supported by the fact that in 2020,CRPA had caused28,8000 nosocomial infections with about 2500 deaths.Apart from porin mutations,the acquisition of Klebsiella pneumoniae carbapenemase(termed as KPC-2)constitutes an alternative mechanism for carbapenem resistance in P.aeruginosa,which compromises the clinical efficacy of the carbapenem as a“last resort”option.Notably,the transferability of blaKPC-2 determinants facilitates global dissemination of CRPA in the context of“one health”consisting of humans,animals,plants/crops,and environmental settings.In addition to antimicrobial stewardship,coordinated global action is necessary to mitigate AMR progression.展开更多
Tetracyclines,a group of antimicrobial agents targeting protein synthesis,have been extensively used in agricultural,veterinary,and clinic settings[1].The sporadic rise in tetracycline resistance is partially due to t...Tetracyclines,a group of antimicrobial agents targeting protein synthesis,have been extensively used in agricultural,veterinary,and clinic settings[1].The sporadic rise in tetracycline resistance is partially due to the occurrence of efflux pumps and/or ribosome protection[1,2].The growing body of tetracycline-inactivating enzymes(e.g.,TetX(X1 to X4)[3,4]and Tet(47 to 55)[5])represents an alternative mechanism for tetracycline resistance,and threatens the renewed interest of tigecycline as a last-resort defense against lethal infections with carbapenem-resistant Enterobacteriaceae and Acinetobacter species.展开更多
基金This work was supported by the National Natural Science Foundation of China(32141001 and 31830001 to Y.F.)the National Science Fund for Distinguished Young Scholar(32125003 to Y.F.)the National Key Basic Research Program of China(2023YFC2307100 and 2023YFC2300021 to Y.F.).
文摘Antimicrobial resistance(AMR)is one of the top global challenges of public health concern.In 2019,it was estimated that AMR claimed around 5 million deaths worldwide[1].Pseudomonas aeruginosa,which originated in soil and water,is recognized as an opportunistic pathogen causing recalcitrant infections.Carbapenem-resistant P.aeruginosa(CRPA)is listed by the World Health Organization(WHO)as an important member of top priority“ESKAPE”pathogens.This is largely supported by the fact that in 2020,CRPA had caused28,8000 nosocomial infections with about 2500 deaths.Apart from porin mutations,the acquisition of Klebsiella pneumoniae carbapenemase(termed as KPC-2)constitutes an alternative mechanism for carbapenem resistance in P.aeruginosa,which compromises the clinical efficacy of the carbapenem as a“last resort”option.Notably,the transferability of blaKPC-2 determinants facilitates global dissemination of CRPA in the context of“one health”consisting of humans,animals,plants/crops,and environmental settings.In addition to antimicrobial stewardship,coordinated global action is necessary to mitigate AMR progression.
基金supported by the National Natural Science Foundation of China(32141001 and 31830001)the National Science Fund for Distinguished Young Scholars(32125003)the National Key R&D Program of China(2022YFC2303900 and 2022YFC3704700)。
基金supported by National Key R&D Program of China(2017YFD0500202,YF)National Natural Science Foundation of China(31830001,31570027&81772142,YF)
文摘Tetracyclines,a group of antimicrobial agents targeting protein synthesis,have been extensively used in agricultural,veterinary,and clinic settings[1].The sporadic rise in tetracycline resistance is partially due to the occurrence of efflux pumps and/or ribosome protection[1,2].The growing body of tetracycline-inactivating enzymes(e.g.,TetX(X1 to X4)[3,4]and Tet(47 to 55)[5])represents an alternative mechanism for tetracycline resistance,and threatens the renewed interest of tigecycline as a last-resort defense against lethal infections with carbapenem-resistant Enterobacteriaceae and Acinetobacter species.
