上海市农业种质资源信息共享服务平台设计与应用

上海市农业种质资源信息共享服务平台是对上海市保护单位的农业种质资源进行规范管理和共享利用的服务体系。为了解决当前规模化和多样化的种质分散于不同保护单位,不利于资源信息共享与利用的问题,本研究根据农业种质资源库(圃)的工作流程研发了以保护单位、资源用户和主管单位为主要角色的一站式共享服务平台,为保护单位建立了管理系统模块,保护单位管理员可进行本单位的种质资源数据管理、资源共享信息发布、申请审核和利用成效管理,促进各保护单位种质资源数据的规范化和共享服务。为资源用户创建了申请共享和利用反馈机制,主要提供种质资源信息查询服务、申请利用服务、利用成效反馈服务等,可同时申请多个保护单位的种质。为主管单位提供全面调查的统计汇总信息,包括全市资源存量、资源分发利用、资源利用成效等信息,实时掌握资源共享动向和利用成效。种质资源信息共享服务平台将为保护单位、资源用户和主管单位提供便捷的服务,有助于提高农业种质资源保存与利用效率。

上海市农作物种质资源信息管理系统设计与应用

农业种质资源管理工作是一项基础性工作,环节多、流程复杂、信息量大。根据种质资源出入库及保存的操作流程与技术规范,需要一套种质资源信息管理系统对种质资源的出入库流程进行规范引导,对种质资源的库存情况及时跟踪,及对库存资源的性状数据信息进行管理。基于面向用户的操作应用于农作物种质资源信息的规范化整理,并重构数据模型,开发农作物种质资源管理系统,对于促进种质资源信息整合,提升种质资源保护和共享利用效率具有重要意义。本研究针对上海市农作物种质资源信息管理系统的建设,围绕系统总体设计、数据规范、数据模型、业务流程和系统应用等方面进行了详细的介绍,并重点介绍出入库管理、库位管理、活力检测管理、资源信息管理、性状数据管理、种子预警、统计汇总等主要的功能模块,旨在为农作物种质资源信息库建设提供参考。

Time-dependent Ginzburg–Landau equations for multi-gap superconductors

We numerically solve the time-dependent Ginzburg–Landau equations for two-gap superconductors using the finite-element technique. The real-time simulation shows that at low magnetic field, the vortices in small-size samples tend to form clusters or other disorder structures. When the sample size is large, stripes appear in the pattern. These results are in good agreement with the previous experimental observations of the intriguing anomalous vortex pattern, providing a reliable theoretical basis for the future applications of multi-gap superconductors.

Laser test of the prototype of CEE time projection chamber

A prototype thick-GEM-based cooling storage ring external-target experiment(CEE) time projection chamber(TPC) is constructed and tested with the pulsed ultraviolet laser beams. The results indicate that the prototype TPC has a good performance in three-dimensional track resolution. In X direction the position resolution is about 0.2 mm, and in Y direction the position resolution is about 0.5 mm. The results also determine that the energy resolution is about 5.4%, which achieve the requirements of the CEE experiment and can be used to study the nuclear state equation and the quantum chromo dynamics.

A method of determining nonlinear large strain consolidation parameters of dredged clays

A method of obtaining the large strain consolidation parameters of dredged clays considering the influence of the initial water content is investigated in this study. According to the test results of remolded clays with high initial water contents reported by Hong et al. （2010）, a relationship between the void ratio （e） and effective stress （a3 is established. Furthermore, based on the available permeability data from the literature, a new relationship between the permeability coefficient （k） and the ratio （e/eL） of the void ratio to the void ratio at the liquid limit （eL） is proposed. The new proposed expression considering the initial water content improves the e-k equation established by Nagaraj et al. （1994）. Finally, the influence of the initial void ratio and effective stress on the large strain consolidation coefficient g（e） defined by Gibson et al. （1981） and k/（1 ＋e） in large strain analysis is discussed. The results show that, under a constant effective stress, the value of k/（1 ＋e） increases with the initial void ratio. The large strain consolidation coefficient shows the law of segmentation change, which decreases with the increase of the effective stress when the effective stress is less than the remolded yield stress, but increases rapidly with the effective stress when the effective stress is larger than the remolded yield stress.

达芬奇机器人手术系统胃癌根治性全胃切除术后并发症及危险因素分析

目的分析达芬奇机器人手术系统胃癌根治性全胃切除术后并发症,探讨影响术后并发症发生的危险因素。方法采用回顾性病例对照研究方法。收集2010年3月至2019年3月陆军军医大学第一附属医院收治的173例胃癌患者的临床病理资料;男138例,女35例;平均年龄为60岁,年龄范围为34~76岁。173例患者均行达芬奇机器人手术系统根治性全胃切除术。观察指标:(1)术后并发症情况。(2)影响达芬奇机器人手术系统胃癌根治性全胃切除术后并发症发生的危险因素分析。计数资料以绝对数或百分比表示。单因素分析采用χ2检验或Fisher确切概率法,将P<0.1因素纳入多因素分析,多因素分析采用Logistic回归模型。结果(1)术后并发症情况:173例患者中,45例术后发生并发症,并发症发生率为26.0%(45/173)。45例术后发生并发症患者中,Ⅰ级5例、Ⅱ级31例、Ⅲa级2例、Ⅲb级3例、Ⅳa级1例、Ⅳb级1例、Ⅴ级2例。Clavien-Dindo并发症分级严重并发症发生率为5.2%(9/173)。5例Ⅰ级并发症患者中,1例发热予以退烧药处理后好转;2例切口脂肪液化予以换药后好转;1例术后呕吐给与止吐药后好转;1例胃肠功能恢复延迟,予以对症治疗后好转。31例Ⅱ级并发症患者中,12例肺部感染,其中6例仅肺部感染,3例合并胸腔积液,1例合并腹腔感染,2例合并肠梗阻,均保守治疗后好转;7例发热予以加强抗感染治疗后好转;4例深静脉导管感染,拔除导管抗感染治疗后好转,其中1例合并双侧胸腔积液;3例吻合口漏,其中1例合并肺部感染、腹腔感染,均保守治疗后好转;2例十二指肠残端漏(1例合并肺部感染、1例合并肺部感染及胸腔积液)均保守治疗后好转;1例腹腔出血保守治疗后好转;1例肠梗阻保守治疗后好转;1例腹腔感染保守治疗后好转。2例Ⅲa级并发症患者中,1例十二指肠残端漏合并腹腔脓肿予以穿刺引流后好转;1例胸腔积液合并肺部感染穿刺引流后好转。3例Ⅲb级并发症患者中,1例腹腔出血再次手术后好转,2例吻合口漏均在无痛胃镜下放置空肠营养管后好转,1例合并腹腔感染,1例合并胸腔积液及腹腔感染均予以穿刺引流后好转。2例Ⅳ级并发症患者中,1例Ⅳa级因麻醉误吸导致呼吸衰竭经治疗后好转,1例Ⅳb级因吻合口漏导致多器官功能衰竭经治疗后好转。2例Ⅴ级并发症患者死亡,其中1例患者术后出现吻合口漏、腹腔出血、多器官功能衰竭,1例术后出现呼吸衰竭、心功能不全。173例患者中,并发症综合指数(CCI)≥25.2发生率为11.0%(19/173)。(2)影响达芬奇机器人手术系统胃癌根治性全胃切除术后并发症发生的危险因素分析。单因素分析结果显示:体质量指数(BMI)、术中出血量、手术时间是影响患者术后并发症发生的相关因素(χ2=4.275,5.057,5.463,P<0.05)。BMI、术中出血量是影响患者术后严重并发症发生的相关因素(χ2=7.517,5.537,P<0.05)。年龄、BMI、Charlson合并症指数是影响患者术后CCI≥25.2的相关因素(χ2=8.946,7.890,4.062,P<0.05)。多因素分析结果显示:肿瘤直径≥3cm、肿瘤部位位于食管胃结合部是影响患者术后并发症发生的独立危险因素(比值比=4.350,2.175,95%可信区间为1.352~14.000,1.018~4.647,P<0.05)。BMI≥25kg/m2是影响患者术后严重并发症发生的独立危险因素(比值比=5.156,95%可信区间为1.120~23.738,P<0.05)。年龄≥60岁、BMI≥25kg/m2、腹部手术史是影响患者术后CCI≥25.2的独立危险因素(比值比=30.928,3.557,6.009,95%可信区间为1.485~644.19,1.082~11.691,1.358~26.592,P<0.05)。结论达芬奇机器人手术系统胃癌根治性全胃切除术后并发症Clavien-Dindo分级为以肺部相关并发症的Ⅱ级并发症较多。CCI能够更好地预测术后严重并发症危险因素。肿瘤直径≥3cm、肿瘤部位位于食管胃结合部是影响患者术后并发症发生的独立危险因素。BMI≥25kg/m2是影响患者术后严重并发症发生的独立危险因素。年龄≥60岁、BMI≥25kg/m2、腹部手术史是影响CCI≥25.2的独立危险因素。

腹腔镜对比开腹手术治疗新辅助化疗后进展期胃癌近期疗效的Meta分析

腹腔镜胃癌根治术治疗早期胃癌获得广泛认可,对进展期胃癌的安全性及可行性也已经得到临床验证,在术中出血、术后恢复方面较开腹手术有优势。新辅助化疗能够降低肿瘤分期,使进展期胃癌病人获得手术机会,进而改善病人预后。新辅助化疗后进展期胃癌病人可否行腹腔镜手术是目前胃癌外科学者面临的一个全新问题。笔者查阅国内外相关文献,采用Meta分析评价腹腔镜对比开腹手术治疗新辅助化疗后进展期胃癌的近期疗效。

Petrogenesis and Geodynamic Implications of the Carboniferous Granitoids in the Dananhu Belt,Eastern Tianshan Orogenic Belt

This paper presents new LA-ICP-MS zircon U-Pb geochronology,whole-rock major and trace element geochemistry,and Sr-Nd isotopes systematically on porphyritic granitic and K-feldspar granitic intrusions from the Dananhu belt,eastern Tianshan orogenic belt(ETOB).Zircon U-Pb dating indicates that the porphyritic granitic and K-feldspar granitic plutons were formed at 357±3 and 311±3 Ma,respectively.The porphyritic granites show geochemical and isotopic characteristics(high Si O2,low Mg O and Mg^#,depleted Sr-Nd isotopic values(about 0.7034 and 6.13,respectively),with Nb/Ta(13.3–14.7)and Zr/Hf(31.0–33.9)ratios)similar to those of the crustal-derived magmas.The above characteristics suggest they were probably originated from juvenile lower crustal materials.The K-feldspar granites also have high Si O2,low Mg O and Mg^#,depleted Sr-Nd isotopic values(0.7033–0.7046 and 4.41–5.67,respectively).But some trace elements contents vary widely,with variable Nb/Ta(12.7–22.7),Zr/Hf(21.3–36.1)and Nb/La(0.38–1.07)ratios,indicating that the K-feldspar granites were formed by partial melting of juvenile lower crustal materials with old crustal materials.Combined with previous data on Carboniferous granitoids in the Dananhu belt,we infer that all the Carboniferous granitic plutons in the Dananhu belt were most likely emplaced in an island arc environment(Dananhu arc).Subsequently,a tectonic transition from oceanic subduction to post-collisional extension probably occurred in the ETOB.

机器人胃癌根治性全胃切除术中长期疗效及预后因素分析

目的分析机器人胃癌根治性全胃切除术的中长期疗效及其预后因素。方法采用回顾性病例对照研究方法。病例纳入标准:(1)行机器人根治性全胃切除术;(2)术后病理确诊为胃腺癌;(3)术前无其他恶性肿瘤病史,未合并其他肿瘤;(4)术前未行化疗、放疗、靶向治疗等。排除标准:(1)年龄<18岁或>80岁;(2)术前影像学等检查发现肺、肝脏等远处转移征象,或行姑息性手术;(3)术中中转开腹;(4)术后病理证实为残端阳性;(5)因出血、梗阻、穿孔等行急诊手术;(6)残胃癌或胃癌复发再次手术;(7)住院期间或术后1个月内因严重并发症死亡。通过Kaplan-Meier法计算患者术后总生存率(OS)和无病生存率(DFS)并绘制生存曲线;应用Cox回归分析方法对预后进行单因素分析,将P<0.1的因素纳入多因素分析。结果根据上述标准,收集2010年3月至2018年11月期间,陆军军医大学第一附属医院普通外科收治的166例达芬奇机器人胃癌根治性全胃切除术患者的临床资料,消化道重建方式采用食管空肠Roux-en-Y吻合术。采用全机器人17例,小切口辅助149例。术中清扫淋巴结总数为(34.8±17.5)枚,第2站淋巴结清扫总数为(10.1±6.7)枚,第2站淋巴结有转移的患者共73例(44.0%)。中位随访时间25(2~109)个月,55例(33.1%)复发转移。全组患者术后3年、5年OS分别为55.8%和46.2%;3年、5年DFS分别为53.4%和45.4%。Ⅰ期、Ⅱ期、Ⅲ期患者术后5年OS分别为78.9%、58.5%及37.1%;术后5年DFS分别为78.9%、59.2%及34.6%。单因素分析显示,术后病理分期、淋巴结清扫总数、第2站淋巴结清扫数目是本组患者术后总生存率的影响因素(均P<0.05)。多因素分析结果显示,术后病理分期[HR(95%CI):ⅢB期为5.357(1.182~24.275),ⅢC期为11.937(2.677~53.226),P<0.001]、第2站淋巴结清扫数目[HR(95%CI):6~10枚为0.562(0.326~0.969),>10枚为0.388(0.176~0.857),P=0.034]是影响本组患者术后OS的独立预后因素。结论机器人根治性全胃切除术中长期疗效满意,术后病理分期、第2站淋巴结清扫数目是本组患者的独立预后因素。

Anisotropic evolution of 4-brane in a 6D generalized Randall-Sundrum model

We investigate a 6D generalized Randall-Sundrum brane world scenario with a bulk cosmological constant.Each stress-energy tensor Tabi on the brane is shown to be similar to a constant vacuum energy.This is consistent with the Randall-Sundrum model,in which each 3-brane Lagrangian yielded a constant vacuum energy.By adopting an anisotropic metric ansatz,we obtain the 5D Friedmann-Robertson-Walker field equations.In a slightly later period,the expansion of the universe is proportional to the square root of time,t21,which is similar to the period of the radiation-dominated regime.Moreover,we investigate the case with two a(t)and two b(t).In a large range of t,we obtain the 3D effective cosmological constantΛeff=-2Ω/3>0,which is independent of the integral constant.Here,the scale factor is an exponential expansion,which is consistent with our present observation of the universe.Our results demonstrate that it is possible to construct a model that solves the dark energy problem,while guaranteeing a positive brane tension.

Cosmic acceleration caused by the extra-dimensional evolution in a generalized Randall-Sundrum model

We investigate an(n+1)-dimensional generalized Randall-Sundrum model with an anisotropic metric which has three different scale factors.One obtains a positive effective cosmological constant Ωeff∼10^−124(in Planck units),which only needs a solution kr≃50−80 without fine tuning.Both the visible and hidden brane tensions are positive,which renders the two branes stable.Then,we find that the Hubble parameter is close to a constant in a large region near its minimum,thus causing the acceleration of the universe.Meanwhile,the scale of extra dimensions is smaller than the observed scale but greater than the Planck length.This may suggest that the observed present acceleration of the universe is caused by the extra-dimensional evolution.