Bone loss is one of the major barriers for human deep space exploration.To date,there has been less effective measures against bone metabolism derangement during long-term spaceflights[1;2].Traditional Chinese Medicin...Bone loss is one of the major barriers for human deep space exploration.To date,there has been less effective measures against bone metabolism derangement during long-term spaceflights[1;2].Traditional Chinese Medicine(TCM)has been used for bone and joint diseases for thousands of years.Osthole(OST),an O-methylated coumarin,is originally extracted from the fruits of Cnidium monnieri which is a main osteoporosis treatment agent in TCM.Studies have demonstrated that OST have multiple pharmacological and biological features including neuroprotective,immunomodulatory,anticancer,hepatoprotective,cardiovascular protective,and antimicrobial activities[3].In addition,numerous studies also suggested that OST has better bone protection effects by enhancing the differentiation and maturation of osteoblasts[4;5].However,the functions of OST in regulation of bone loss induced by microgravity remain unclear.展开更多
文摘Bone loss is one of the major barriers for human deep space exploration.To date,there has been less effective measures against bone metabolism derangement during long-term spaceflights[1;2].Traditional Chinese Medicine(TCM)has been used for bone and joint diseases for thousands of years.Osthole(OST),an O-methylated coumarin,is originally extracted from the fruits of Cnidium monnieri which is a main osteoporosis treatment agent in TCM.Studies have demonstrated that OST have multiple pharmacological and biological features including neuroprotective,immunomodulatory,anticancer,hepatoprotective,cardiovascular protective,and antimicrobial activities[3].In addition,numerous studies also suggested that OST has better bone protection effects by enhancing the differentiation and maturation of osteoblasts[4;5].However,the functions of OST in regulation of bone loss induced by microgravity remain unclear.
