银杏二萜内酯葡胺联合尤瑞克林治疗急性脑梗死的临床疗效

目的 探讨银杏二萜内酯葡胺联合尤瑞克林治疗急性脑梗死(acute cerebral infarction, ACI)的临床疗效。方法 将84例ACI患者分为观察组与对照组,每组42例。两组均予尤瑞克林治疗,观察组另予银杏二萜内酯葡胺治疗。比较两组治疗前后血流动力学指标,包括平均血流速度(mean blood flow velocity, MBFV)、椎动脉血流量(vertebral artery blood flow, VABF)、基底动脉血流量(basilar artery blood flow, BABF),神经功能指标,包括神经元特异性烯醇化酶(neuron specific enolase, NSE)、同型半胱氨酸(homocysteine, Hcy)、中枢神经特异蛋白(S100-β)和美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale, NIHSS)评分,以及炎性因子指标,包括超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β),观察两组临床疗效和不良反应发生情况。结果 观察组治疗总有效率较对照组高(95.24%vs.80.95%, P=0.043);治疗后观察组MBFV、VABF及BABF均高于对照组,NSE、Hcy、S100-β水平及NIHSS评分均较对照组低(P <0.001),hs-CRP、IL-6及IL-1β水平均较对照组低(P <0.001);治疗2周后两组患者颜面潮红、乏力、心悸、皮疹及胃肠道不适等不良反应发生率比较,差异无统计学意义(P> 0.05)。结论 银杏二萜内酯葡胺联合尤瑞克林治疗ACI患者有助于改善血流动力学和神经功能,抑制炎症反应。

2023年第3版《NCCN肿瘤临床实践指南:非小细胞肺癌》更新解读

肺癌是我国发病率和死亡率均居首位的恶性肿瘤,非小细胞肺癌(non-small cell lung cancer,NSCLC)是肺癌的主要病理学亚型。2023年4月13日,美国国立综合癌症网络(National Comprehensive Cancer Network,NCCN)发布了2023年第3版《NCCN肿瘤临床实践指南:非小细胞肺癌》,其反映了国际肺癌研究的最新进展。本文将对新版《指南》主要更新内容进行解读,并与2022年第3版NCCN指南相比较,旨在为我国临床医务人员诊治NSCLC提供参考。

首个降低胆固醇的siRNA药物——Inclisiran

血脂异常可以引起多种疾病,临床上大多采用他汀类药物来降低低密度脂蛋白胆固醇(Low density lipoprotein-cholesterol,LDL-C)浓度,但部分患者应用后仍不能使LDL-C浓度降到正常水平.Inclisiran是前蛋白转化酶枯草溶菌素9(Proprotein convertase subtilisin/kexin type 9,PCSK9)的特异性小干扰RNA(Small interfering RNA,siRNA),可阻止PCSK9信使RNA的翻译,从而降低蛋白质浓度和LDL-C浓度,可治疗动脉粥样硬化和高胆固醇血症等心血管疾病,在临床上还可与他汀类药物联合使用来增强疗效.ORION临床开发计划有部分试验还在进行,主要对其安全性及对心血管结局的改善能力进行评估.本文主要对Inclisiran的临床药理学、临床试验、不良事件和联合用药等进行综述,希望为Inclisiran临床应用提供支持.

Developing time-of-flight polarized neutron capability at the China Spallation Neutron Source

Polarized neutrons play an indispensable role in neutron scattering research and have been incorporated into various neutron diffractometers and spectrometers. Recognizing the importance of polarized neutrons, the China Spallation Neutron Source(CSNS) has dedicated resources for developing its own capabilities for polarized neutron techniques. Hence, a polarized neutron development platform was allocated to the BL-20 beam port at CSNS for the purpose of facilitating new technological developments and calibration of instruments. Here, we report the progress we have made in terms of using the established development platform at BL-20, including the characterization of neutron spin filter cells manufactured at CSNS, the calibration of self-developed polarized neutron instruments, performance of the polarized neutron technique applied to beamlines,and associated simulation work for beamline magnetic field environments. These results demonstrate the capability of the CSNS to develop time-of-flight polarized neutron instruments and techniques in-house, which will be incorporated into the construction of CSNS neutron beamlines.

Hogan理论阶段性护理干预对宫颈癌患者配偶家庭功能的影响分析

目的探究基于Hogan理论阶段性护理干预对宫颈癌患者配偶家庭功能的影响。方法选取2017年1月至2019年12月徐州市中心医院收治的136例宫颈癌患者配偶作为研究对象。采用基于Hogan理论阶段性护理干预的宫颈癌患者配偶作为观察组(n=68),采用常规护理干预的宫颈癌患者配偶作为对照组(n=68)。比较两组护理前后家庭功能、焦虑情绪变化及护理满意度。结果观察组护理2个月后角色功能、行为控制、情感反应、情感介入、问题解决、沟通交流及家庭功能总分均低于对照组,差异具有统计学意义(P<0.05);观察组护理2个月后Zung氏焦虑自评量表(SAS)评分低于对照组,差异具有统计学意义(P<0.05);观察组护理满意度高对照组,差异具有统计学意义(P<0.05)。结论基于Hogan理论阶段性护理干预应用于宫颈癌患者配偶可有效提高其家庭功能及护理满意度,同时可缓解焦虑情绪,值得临床推广。

身心放松干预对卵巢癌患者生活质量及负性情绪的影响

目的探究身心放松干预对卵巢癌患者生活质量及负性情绪的影响。方法选取徐州市中心医院2017年2月至2019年3月诊治的136例卵巢癌患者作为研究对象。采用身心放松干预的卵巢癌患者68例作为观察组,采用常规干预的卵巢癌患者68例作为对照组。采用焦虑自评量表(SAS)和抑郁自评量表(SDS)分别评定两组患者的焦虑和抑郁情绪,采用癌症疲乏量表(CFS)和生活质量评估量表(WHOQOL-100)评价两组患者的癌因性疲乏程度及生活质量。结果观察组患者干预3个月后SAS、SDS评分均低于对照组患者,差异均具有统计学意义(均P<0.05);观察组患者干预3个月后CFS评分低于对照组患者,差异具有统计学意义(P<0.05);观察组患者干预3个月后各生活质量评分均高于对照组患者,差异均具有统计学意义(均P<0.05)。结论身心放松干预应用于卵巢癌患者可有效改善其负性情绪,降低癌因性疲乏程度,同时提高生活质量,值得临床推广。

运动台签对预防妇科肿瘤患者术后下肢深静脉血栓形成的影响分析

目的探究运动台签在预防妇科肿瘤患者术后下肢深静脉血栓形成中的应用效果。方法选取2017年2月至2019年2月徐州市中心医院妇科收治的100例肿瘤手术患者作为研究对象。按随机数字表法分为观察组(n=50)和对照组(n=50)。观察组行基于运动台签的干预,对照组行常规干预。比较两组术后下肢深静脉血栓形成、下肢肿胀、下肢疼痛、肺栓塞发生率及生活质量、临床满意度情况。结果观察组术后下肢深静脉血栓形成、下肢肿胀、下肢疼痛发生率均低于对照组,差异具有统计学意义(P<0.05);观察组术后躯体功能、心理功能、物质生活、社会功能评分均高于对照组,差异具有统计学意义(P<0.05);观察组临床满意度高于对照组,差异具有统计学意义(P<0.05)。结论运动台签应用于妇科肿瘤患者术后可有效预防下肢深静脉血栓形成发生,改善患者生活质量,提高满意度,值得推广。

Expression and localization of CKLFSF2 in human spermatogenesis

Aim： To investigate the expression and subcellular localization of chemokine-like factor superfamily 2 （CKLFSF2） in human testis and its potential role in spermatogenesis. Methods： A specific polyclonal antibody against CKLFSF2 was raised. The expression and cellular localization of CKLFSF2 in the seminiferous tubules was checked by immunohistochemistry method. Also, in situ hybridization was applied to localize the mRNA distribution. The EGFP- CKLFSF2 fusion protein was expressed in COS-7 cells to localize its subcellular location in vitro. In addition, the abnormal expression of CKLFSF2 in testes of patients with male infertility was assayed by reverse transcription polymerase chain reaction （RT-PCR） and immunohistochemistry methods. Results： Having a close correlation with spermatogenesis defects, CKLFSF2 was specifically expressed in meiotic and post-meiotic germ cells, which were localized to the endoplasmic reticulum （ER） near the Golgi apparatus. Conclusion： CKLFSF2 could play important roles in the process of meiosis and spermiogenesis, and might be involved in the vesicular transport or membrane apposition events in the endoplasmic reticulum.

Cox7a2 mediates steroidogenesis in TM3 mouse Leydig cells

Aim： To investigate the regulatory function of Cox7a2 on steroidogenesis and the mechanism involved in TM3 mouse Leydig cells. Methods： The cDNA of Cox7a2 was cloned from TM3 mouse Leydig cells. It was subcloned to pDsRed- Express-N 1 and transfected back into TM3 mouse Leydig cells for Cox7a2 overexpression by transient gene transfection. Steroidogenesis affected by overexpressed Cox7a2 was studied by ELISA. To elicit the mechanism of this effect, expression of steroidogenic acute regulatory （STAR） protein and reactive oxygen species （ROS） were examined by Western blot and fluorometer, respectively. Results： The cDNA of Cox7a2 （249 bp） was cloned from Leydig cells and confirmed by DNA sequencing. After constructed pDsRed-Express-N1-Cox7a2 was transfected back into TM3 mouse Leydig cells, Cox7a2 inhibited not only luteinizing hormone （LH）-induced secretion of testosterone but also the expression of StAR protein. At the same time, Cox7a2 increased the activity of ROS in TM3 mouse Leydig cells. Conclusion： Cox7a2 inhibited LH-induced StAR protein expression, and consequent testosterone production, at least in part, by increasing ROS activity in TM3 mouse Leydig cells.

A low-noise, high-SNR balanced homodyne detector for the bright squeezed state measurement in 1–100 kHz range

We report a low-noise, high-signal-to-noise-ratio(SNR) balanced homodyne detector based on the standard transimpedance amplifier circuit and the inductance and capacitance combination for the measurement of the bright squeezed state in the range from 1 kHz to 100 kHz. A capacitance is mounted at the input end of the AC branch to prevent the DC photocurrent from entering the AC branch and avoid AC branch saturation. By adding a switch at the DC branch,the DC branch can be flexibly turned on and off on different occasions. When the switch is on, the DC output provides a monitor signal for laser beam alignment. When the switch is off, the electronic noise of the AC branch is greatly reduced at audio-frequency band due to immunity to the impedance of the DC branch, hence the SNR of the AC branch is significantly improved. As a result, the electronic noise of the AC branch is close to -125 dBm, and the maximum SNR of the AC branch is 48 dB with the incident power of 8 mW in the range from 1 kHz to 100 kHz. The developed photodetector paves a path for measuring the bright squeezed state at audio-frequency band.

Miniaturized time-of-flight neutron spin flipper using a high-TC superconductor

A miniaturized neutron spin flipper based on a high-TC superconductor film,developed at the China Spallation Neutron Source(CSNS),is presented.A neutron spin flipper is an essential component for performing polarized neutron experiments and,as such,constitutes a high priority for developing CSNS’s polarized neutron capability.To provide the beamlines with a universal neutron spin flipper operating over a wide wavelength band,the neutron spin flipper utilizes non-adiabatic spin flipping during transit through opposite magnetic fields that are mutually shielded by the superconductor Meissner effect.A compact vacuum heat shield and a low-power consumption sterling refrigerator maintained the superconducting condition while reducing the size and power input of the flipper.The prototype device was tested at the CSNS BL-20,which demonstrated a flipping efficiency of 99%at 4 A°.

含锶/锌钙磷涂层对RAW264.7破骨细胞体外影响的研究

目的:研究锶或锌加入电化学沉积钙磷涂层后对类破骨细胞增殖和分化的影响。方法:以电化学沉积钙磷涂层为对照组,与加入锶或锌的电化学沉积钙磷涂层相比较。3种涂层分别接种RAW264.7细胞培养8d,采用细胞计数试剂盒(cell counting kit-8,CCK-8)检测细胞培养6d后的增殖情况,同时检测细胞培养8d后的抗酒石酸酸性磷酸酶(tartrate resistant acid phosphatase,TRAP)活性。结果:3种涂层接种RAW264.7细胞后,使用CCK-8试剂盒检测,结果显示第4小时时加入锌的钙磷涂层其吸光度值明显高于其他两组,但第2天时的细胞增殖指数低于其他两组(P<0.05)。第14天的TRAP酶活性检测结果显示3组间比较差异无统计学意义。结论:含锌电化学沉积钙磷涂层促进破骨细胞的粘附,但加入锶或锌对类破骨细胞在电化学沉积钙磷涂层表面的增殖和分化无影响。

Automatic Event Trigger Word Extraction in Chinese Event

As a basic unit of knowledge representation and an important means for information organization, event has drawn growing number of people’s attention, the research of event identification and extraction in natural language processing field is an important research topic in information extraction area, the recognition and extraction of event trigger word plays a decisive role in event identification and extraction. In this paper, the authors make experiment in Chinese Event Corpus CEC, and present a method of extracting event trigger word automatically that combines extended trigger word table and machine learning. The experiment result shows that the F-score of extracting event trigger word. can reach 71.2% by using this method.

Excess-iron driven spin glass phase in Fe_(1+y)Te_(1-x)S_(ex)

The iron-chalcogenide superconductor FeTe_(1-x)Se_(x) displays a variety of exotic features distinct from iron pnictides.Although much effort has been devoted to understanding the interplay between magnetism and superconductivity near x=0.5,the existence of a spin glass phase with short-range magnetic order in the doping range(x~0.1-0.3)has rarely been studied.Here,we use DC/AC magnetization and(quasi)elastic neutron scattering to confirm the spin-glass nature of the short-range magnetic order in a Fe_(1.07)Te_(0.8)Se_(0.2) sample.The AC-frequency dependent spin-freezing temperature T_(f) generates a frequency sensitivityΔT_(f)(ω)/[T_(f)(ω)Δlog_(10)ω]≈0.028 and the description of the critical slowing down withτ=τ0(T_(f)/T_(SG-1))^(-zv) gives T_(SG)≈22 K and zv≈10,comparable to that of a classical spin-glass system.We have also extended the frequency-dependent T_(f) to the smaller time scale using energy-resolution-dependent neutron diffraction measurements,in which the T_(N) of the short-range magnetic order increases systematically with increasing energy resolution.By removing the excess iron through annealing in oxygen,the spin-freezing behavior disappears,and bulk superconductivity is realized.Thus,the excess Fe is the driving force for the formation of the spin-glass phase detrimental to bulk superconductivity.

Less pressure contributes to gravity-driven membrane ultrafiltration with greater performance:Enhanced driving efficiency and reduced disinfection by-products formation potential

Gravity-driven membrane(GDM)systems have been well developed previously;however,impacts of driving(i.e.,transmembrane)pressure on their performance received little attention,which may infuence GDM performance.In this study,we evaluated 4 GDM systems via altering the transmembrane pressure from 50 mbar to 150 mbar with 2 groups,treating surface water in Beijing,China.Results showed that less driving pressure was more favorable.Specifically,compared to groups(150 mbar),groups under a pressure of 50 mbar were found to have greater normalized permeability and lower total resistance.During the whole operation period,the quality of effuents was gradually improved.For example,the removal efficiency of UV254was significantly improved;particularly,under low driving pressure,the removal efficiency of UV254in PES GDM system increased by 11.91%,as compared to the corresponding system under high driving pressure.This observation was consistent with the reduction on disinfection by-products(DBPs)formation potential;groups under 50 mbar achieved better DBPs potential control,indicating the advantages of lower driving pressure.Biofilms were analyzed and responsible for these differences,and distinct distributions of bacteria communities of two GDM systems under 50 and 150 mbar may be responsible for various humic-like substances removal efficiency.Overall,GDM systems under less pressure should be considered and expected to provide suggestions on the design of GDM systems in real applications.

Squeezing-enhanced resolution of radio-frequency signals

We demonstrate a resolution enhancement scheme of radio-frequency signals by tailoring a phase-squeezed state.The echo radio-frequency signals collected by photonic radar give rise to displacements in the phase quadrature of a probe laser and are estimated by the balanced homodyne detector.In contrast to the conventional coherent state,the noise variances for radio-frequency estimation with a squeezed state are reduced by approximately 6.9 dB.According to the Rayleigh criterion that defines the resolution limit,the minimum resolvable displacement Δa with a squeezed state is reduced to 45%compared to that with a coherent state,demonstrating the quantum advantage.The squeezing-enhanced technique has extensive applications for multitarget recognition and tracking in contemporary photonic radar systems.

文化资源与出版融合发展的实践模式探究

国家文化数字化战略是实现建成文化强国远景目标的必然要求,出版单位尤其是电子音像出版单位需要抓住这一发展契机,快速实现转型升级。文章从文化资源数字资产构建、创新呈现方式及新消费应用场景探索等方面阐述文化资源与出版融合的实施模式,通过案例分享分析归纳了发展过程中的经验与教训。

Bats as the main prey of wintering long-eared owl(Asio otus)in Beijing:Integrating biodiversity protection and urban management

The loss of biodiversity from urbanized areas is a major environmental problem challenging policy-makers throughout the world.Solutions to this problem are urgently required in China.We carried out a case study of wintering long-eared owls(Asio otus)and their main prey to illustrate the negative effects of urbanization combined with ineffective conservation of biodiversity in Beijing.Field monitoring of owl numbers at two roosting sites from 2004 to 2012 showed that the owl population had fallen rapidly in metropolitan Beijing.Analysis of pellet contents identified only seven individuals of two species of shrew.The majority of mammalian prey comprised four bat and seven rodent species,making up 29.3%and 29.5%of the prey items,respectively.Prey composition varied significantly among years at the two sample sites.At the urban site the consumption of bats and rodents declined gradually over time,while predation on birds increased.In contrast,at the suburban site the prey composition showed an overall decrease in the number of bats,a sharp increase and a subsequent decrease in bird prey,and the number of rodent prey fell to a low point.Rapid development of real estate and inadequate greenfield management in city parks resulted in negative effects on the bird and small mammal habitat of urban areas in Beijing.We suggest that measures to conserve biodiversity should be integrated into future urban planning to maintain China’s rich biodiversity while also achieving sustainable economic development.