α-Aryl-α,α-difluoroacetophenones(DFAPs)are developed as a new class of difluorobenzylation reagents that can be facilely prepared from readily available and cheap starting materials.In situ carbon-carbon bond cleav...α-Aryl-α,α-difluoroacetophenones(DFAPs)are developed as a new class of difluorobenzylation reagents that can be facilely prepared from readily available and cheap starting materials.In situ carbon-carbon bond cleavage of electron-deficient DFAPs gives difluorobenzyl carbanions that undergo base-catalyzed nucleophilic addition to isatins.展开更多
基金This work was supported by the Jiangxi Provincial Department of Science and Technology Fund(20192BAB213007)the Jiangxi Provincial Education Department Science Fund(GJJ201424)the Key Laboratory of Jiangxi University for Functional Materials Chemistry(No.FMCyl31007005).
文摘α-Aryl-α,α-difluoroacetophenones(DFAPs)are developed as a new class of difluorobenzylation reagents that can be facilely prepared from readily available and cheap starting materials.In situ carbon-carbon bond cleavage of electron-deficient DFAPs gives difluorobenzyl carbanions that undergo base-catalyzed nucleophilic addition to isatins.
