With the rapid development of China's economy,people's demand for a healthy living environment is increasing,and air quality has gradually been widely concerned by all sectors of society.Using the big data of ...With the rapid development of China's economy,people's demand for a healthy living environment is increasing,and air quality has gradually been widely concerned by all sectors of society.Using the big data of air quality monitoring from 1998 to 2016,based on the exploratory spatio-temporal analysis method,this paper explored the spatio-temporal evolution of PM_(2.5) at the national scale,and drew the following conclusions:①PM_(2.5) heavy pollution is mainly in central and eastern China,north and south China,and the pollution degree is relatively light in northwest and northeast China.Meanwhile,PM_(2.5) concentration in heavily polluted areas increased significantly over time,while PM_(2.5) concentration in low-polluted areas showed a long-term stable trend.②The number and area of cities with moderate and high PM_(2.5) pollution levels showed an inverted U-shaped curve from 1998 to 2016,and 2007 was the inflection point.③The spatial autocorrelation coefficient of PM_(2.5) is high over the years,and the spatial neighbor effect of PM_(2.5) is significant.The high-pollution clusters are mainly concentrated in the Beijing-Tianjin-Hebei region,the Yangtze River Delta and the Pearl River Delta,and the pollution concentration in these three regions has increased rapidly in recent years.It is necessary to focus on joint prevention and control.展开更多
Background:The development of immunotherapy resistance is associated with a poor prognosis in patients diagnosed with hepatocellular carcinoma(HCC)who are undergoing treatment with immune checkpoint inhibitors(ICI).Th...Background:The development of immunotherapy resistance is associated with a poor prognosis in patients diagnosed with hepatocellular carcinoma(HCC)who are undergoing treatment with immune checkpoint inhibitors(ICI).This study aimed to evaluate the efficacy and safety of subsequent radiotherapy(RT)for patients with advanced-stage HCC who had lesion enlargement or new lesions(NLs)during ICI therapy.Methods:This retrospective observational study enrolled 36 patients with advanced-stage HCC who underwent subsequent RT for lesion enlargement or NLs during ICI therapy from two centers.The primary endpoints were progression-free survival(PFS)and overall survival(OS).The secondary endpoints included objective response rate(ORR),disease control rate(DCR),1-and 2-year local control(LC)rates,in-field PFS(IFPFS),out-field PFS(OFPFS),and safety.Results:The median follow-up time was 15.3 months.The median PFS was 7.4 months[95%confidence interval(CI):3.1-11.7 months],and the median OS was 18.8 months(95%CI:17.1-20.5 months).ORR and DCR were 38.9%and 72.2%,respectively.In addition,the median IFPFS was 17.8 months(95%CI:11.5-24.2 months),median OFPFS was 7.9 months(95%CI:3.4-12.5 months),and estimated 1-and 2-year LC rates were 67.1%and 31.9%,respectively.The most common treatment-related adverse events(all grades)were diarrhea(33.3%),rash(30.6%),and malaise(27.8%);a total of 14(38.9%)patients developed grade 3-4 AEs.Conclusions:Subsequent RT showed reliable antitumor effects and an acceptable safety profile in patients with advanced-stage HCC who had unsatisfactory response to ICI therapy;therefore,it could serve as an optional salvage strategy.展开更多
基金Supported by the National Natural Science Foundation of China(51808413)General Project of Hubei Social Science Fund(Later Funded Project)(2020158)Innovation and Entrepreneurship Training Program for College Students in Hubei Province(S202010490027)。
文摘With the rapid development of China's economy,people's demand for a healthy living environment is increasing,and air quality has gradually been widely concerned by all sectors of society.Using the big data of air quality monitoring from 1998 to 2016,based on the exploratory spatio-temporal analysis method,this paper explored the spatio-temporal evolution of PM_(2.5) at the national scale,and drew the following conclusions:①PM_(2.5) heavy pollution is mainly in central and eastern China,north and south China,and the pollution degree is relatively light in northwest and northeast China.Meanwhile,PM_(2.5) concentration in heavily polluted areas increased significantly over time,while PM_(2.5) concentration in low-polluted areas showed a long-term stable trend.②The number and area of cities with moderate and high PM_(2.5) pollution levels showed an inverted U-shaped curve from 1998 to 2016,and 2007 was the inflection point.③The spatial autocorrelation coefficient of PM_(2.5) is high over the years,and the spatial neighbor effect of PM_(2.5) is significant.The high-pollution clusters are mainly concentrated in the Beijing-Tianjin-Hebei region,the Yangtze River Delta and the Pearl River Delta,and the pollution concentration in these three regions has increased rapidly in recent years.It is necessary to focus on joint prevention and control.
基金supported by the National High Level Hospital Clinical Research Funding (2022-PUMCH-B-128)the CAMS Innovation Fund for Medical Sciences (2022-I2M-C&T-A-003)the CSCO-Hengrui Cancer Research Fund (Y-HR2020MS-0415 and Y-HR2020QN-0414).
文摘Background:The development of immunotherapy resistance is associated with a poor prognosis in patients diagnosed with hepatocellular carcinoma(HCC)who are undergoing treatment with immune checkpoint inhibitors(ICI).This study aimed to evaluate the efficacy and safety of subsequent radiotherapy(RT)for patients with advanced-stage HCC who had lesion enlargement or new lesions(NLs)during ICI therapy.Methods:This retrospective observational study enrolled 36 patients with advanced-stage HCC who underwent subsequent RT for lesion enlargement or NLs during ICI therapy from two centers.The primary endpoints were progression-free survival(PFS)and overall survival(OS).The secondary endpoints included objective response rate(ORR),disease control rate(DCR),1-and 2-year local control(LC)rates,in-field PFS(IFPFS),out-field PFS(OFPFS),and safety.Results:The median follow-up time was 15.3 months.The median PFS was 7.4 months[95%confidence interval(CI):3.1-11.7 months],and the median OS was 18.8 months(95%CI:17.1-20.5 months).ORR and DCR were 38.9%and 72.2%,respectively.In addition,the median IFPFS was 17.8 months(95%CI:11.5-24.2 months),median OFPFS was 7.9 months(95%CI:3.4-12.5 months),and estimated 1-and 2-year LC rates were 67.1%and 31.9%,respectively.The most common treatment-related adverse events(all grades)were diarrhea(33.3%),rash(30.6%),and malaise(27.8%);a total of 14(38.9%)patients developed grade 3-4 AEs.Conclusions:Subsequent RT showed reliable antitumor effects and an acceptable safety profile in patients with advanced-stage HCC who had unsatisfactory response to ICI therapy;therefore,it could serve as an optional salvage strategy.
基金supported by the National Key R&D Program of China(2017YFA0207800)the National Natural Science Foundation of China(21574004)+4 种基金the National Natural Science Funds for Distinguished Young Scholar(21725401)the 111 project(B14009)the Fundamental Research Funds for the Central Universitiesthe National “Young Thousand Talents Program”the China Postdoctoral Science Foundation(2017M620012)