The Janus kinase-signal transducer and activator of transcription(JAK-STAT)pathway serves as a paradigm for signal transduction from the extracellular environment to the nucleus.It plays a pivotal role in physiologica...The Janus kinase-signal transducer and activator of transcription(JAK-STAT)pathway serves as a paradigm for signal transduction from the extracellular environment to the nucleus.It plays a pivotal role in physiological functions,such as hematopoiesis,immune balance,tissue homeostasis,and surveillance against tumors.Dysregulation of this pathway may lead to various disease conditions such as immune deficiencies,autoimmune diseases,hematologic disorders,and cancer.Due to its critical role in maintaining human health and involvement in disease,extensive studies have been conducted on this pathway,ranging from basic research to medical applications.Advances in the structural biology of this pathway have enabled us to gain insights into how the signaling cascade operates at the molecular level,laying the groundwork for therapeutic development targeting this pathway.Various strategies have been developed to restore its normal function,with promising therapeutic potential.Enhanced comprehension of these molecular mechanisms,combined with advances in protein engineering methodologies,has allowed us to engineer cytokines with tailored properties for targeted therapeutic applications,thereby enhancing their efficiency and safety.In this review,we outline the structural basis that governs key nodes in this pathway,offering a comprehensive overview of the signal transduction process.Furthermore,we explore recent advances in cytokine engineering for therapeutic development in this pathway.展开更多
Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/s41392-024-01934-w,published online 21 August 2024 After online publication of the Article,1 the authors received feedback from a reader t...Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/s41392-024-01934-w,published online 21 August 2024 After online publication of the Article,1 the authors received feedback from a reader that an inadvertent error was found on earlier understanding on the organizing principle of common beta cytokine signaling.A recent study published in the journal Molecular Cell updates our understanding of the hexameric structural model of theβc family cytokine-receptor complex signaling transduction.2 Unfortunately,we did not catch these new findings during the revision of our manuscript.Here,we update Fig.4 and its legend of the original Article and correct the related descriptions of theβc family cytokine signaling model in the main text.These corrections did not affect any of our key conclusions presented in the original Article.We apologize for any inconvenience this has caused.The original Article has been corrected.展开更多
基金funded by the XUST seeding grant and a national talent program grant(Grant numbers:2050122039 and 6119924022)funded by the National Health and Medical Research Council(Investigator 2025931)Australian Research Council(Laureate Fellowship FL180100109).
文摘The Janus kinase-signal transducer and activator of transcription(JAK-STAT)pathway serves as a paradigm for signal transduction from the extracellular environment to the nucleus.It plays a pivotal role in physiological functions,such as hematopoiesis,immune balance,tissue homeostasis,and surveillance against tumors.Dysregulation of this pathway may lead to various disease conditions such as immune deficiencies,autoimmune diseases,hematologic disorders,and cancer.Due to its critical role in maintaining human health and involvement in disease,extensive studies have been conducted on this pathway,ranging from basic research to medical applications.Advances in the structural biology of this pathway have enabled us to gain insights into how the signaling cascade operates at the molecular level,laying the groundwork for therapeutic development targeting this pathway.Various strategies have been developed to restore its normal function,with promising therapeutic potential.Enhanced comprehension of these molecular mechanisms,combined with advances in protein engineering methodologies,has allowed us to engineer cytokines with tailored properties for targeted therapeutic applications,thereby enhancing their efficiency and safety.In this review,we outline the structural basis that governs key nodes in this pathway,offering a comprehensive overview of the signal transduction process.Furthermore,we explore recent advances in cytokine engineering for therapeutic development in this pathway.
文摘Correction to:Signal Transduction and Targeted Therapy https://doi.org/10.1038/s41392-024-01934-w,published online 21 August 2024 After online publication of the Article,1 the authors received feedback from a reader that an inadvertent error was found on earlier understanding on the organizing principle of common beta cytokine signaling.A recent study published in the journal Molecular Cell updates our understanding of the hexameric structural model of theβc family cytokine-receptor complex signaling transduction.2 Unfortunately,we did not catch these new findings during the revision of our manuscript.Here,we update Fig.4 and its legend of the original Article and correct the related descriptions of theβc family cytokine signaling model in the main text.These corrections did not affect any of our key conclusions presented in the original Article.We apologize for any inconvenience this has caused.The original Article has been corrected.
