Peritoneal seedings of a colorectal tumor represent the second most frequent site of metastasis(after the liver).In the era of 5-fluorouracil(5-FU)-only chemotherapy,the prognosis was poor for colorectal cancer with p...Peritoneal seedings of a colorectal tumor represent the second most frequent site of metastasis(after the liver).In the era of 5-fluorouracil(5-FU)-only chemotherapy,the prognosis was poor for colorectal cancer with peritoneal metastases.Within the last few years,new chemotherapeutic and targeted agents have improved the prognosis;however,the response to these treatments seems to be lower than that for liver metastases.The combination of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy have further improved both disease-free survival and overall survival.Keeping this in mind,every patient presenting with peritoneal metastases from colorectal cancer should be evaluated and receive adequate treatment,if possible in the above-mentioned combination.This paper reviews recent advancements in the therapy of peritoneal carcinomatosis.展开更多
文摘Peritoneal seedings of a colorectal tumor represent the second most frequent site of metastasis(after the liver).In the era of 5-fluorouracil(5-FU)-only chemotherapy,the prognosis was poor for colorectal cancer with peritoneal metastases.Within the last few years,new chemotherapeutic and targeted agents have improved the prognosis;however,the response to these treatments seems to be lower than that for liver metastases.The combination of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy have further improved both disease-free survival and overall survival.Keeping this in mind,every patient presenting with peritoneal metastases from colorectal cancer should be evaluated and receive adequate treatment,if possible in the above-mentioned combination.This paper reviews recent advancements in the therapy of peritoneal carcinomatosis.
