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孤立性心房颤动时心房利钠肽和脑利钠肽水平不一致
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作者 Ellinor P.T. low a.f. +1 位作者 Patton K.K. 宁宁 《世界核心医学期刊文摘(心脏病学分册)》 2005年第5期59-59,共1页
We sought to characterize natriuretic peptide levels in a cohort of rigorously characterized subjects with lone atrial fibrillation(AF). Atrial natriuretic peptide(ANP)and brain natriuretic peptide(BNP)are sensitive b... We sought to characterize natriuretic peptide levels in a cohort of rigorously characterized subjects with lone atrial fibrillation(AF). Atrial natriuretic peptide(ANP)and brain natriuretic peptide(BNP)are sensitive biomarkers of cardiac contractile dysfunction. Both peptides have been reported to be elevated in cohorts with AF, but previous studies have included subjects with underlying structural heart disease. We studied these hormones in 150 subjects with lone AF. Study subjects had electrocardiographic evidence of at least one episode of AF and a structurally normal heart on echocardiography. Subjects were excluded if they had a history of a myocardial infarction, rheumatic heart disease, cardiomyopathy, significant valvular disease, hyperthyroidism, or hypertension that preceded the onset of AF. Control subjects were obtained from a healthy outpatient primary care population. Plasma pro-ANP and N-terminal pro-BNP(nt-pro-BNP)levels were determined using commercially available immunoassays. A total of 150 serial subjects with lone AF were enrolled and studied, the majority during normal sinus rhythm. Median levels of nt-pro-BNP were significantly elevated in subjects with lone AF as compared with control subjects(166 vs. 133 fmol/ml, p=0.0003). There was no significant difference in pro-ANP levels between subjects with lone AF and control subjects(1,730 vs. 1,625 fmol/ml, p=0.90). Discordant natriuretic peptide levels were observed in this homogeneous population of subjects with lone AF. This biomarker pattern, which is present even in sinus rhythm, may represent an underlying subclinical predisposition to this common arrhythmia. 展开更多
关键词 孤立性心房颤动 脑利钠肽 正常窦性心律 心脏收缩功能 心肌梗死病史 风湿性心脏病 甲状腺机能亢进 心瓣膜病 心肌病 生物标志物
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孤立性房颤患者的apelin水平降低
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作者 Ellinor P. T. low a.f. +2 位作者 MacRae C. A. 黎一兵(译) 马超(校) 《世界核心医学期刊文摘(心脏病学分册)》 2006年第6期48-48,共1页
Aims: Apelin is an endogenous peptide hormone that appears to have a physiological role in counter- regulation of the angiotensin and vasopressin systems. This peptide has been reported to be down- regulated in subjec... Aims: Apelin is an endogenous peptide hormone that appears to have a physiological role in counter- regulation of the angiotensin and vasopressin systems. This peptide has been reported to be down- regulated in subjects with acute heart failure, but has not been studied in other cardiovascular conditions. We studied apelin levels in 73 subjects with lone atrial fibrillation(AF). Methods and results: Study subjects had electrocardiographic evidence of paroxysmal or chronic AF and a structurally normal heart on echocardiography. Subjects were excluded if they had a history of coronary artery disease, rheumatic heart disease, cardiomyopathy, significant valvular disease, hyperthyroidism, or antecedent hypertension. Controls were recruited from a healthy outpatient population. Plasma apelin levels were determined using a commercially available immunoassay. Seventy- three subjects with lone AF and 73 healthy controls were enrolled and studied. Mean levels of apelin were significantly lower in subjects with lone AF when compared with controls(307 vs. 648 pg/mL, P < 0.00005). Conclusion: Reduced apelin levels were observed in this homogenous population of lone AF subjects and may represent an underlying diathesis predisposing to this common arrhythmia. 展开更多
关键词 APELIN 房颤患者 血浆水平 孤立性 心血管疾病患者 超声心动图检查 甲状腺功能亢进 免疫测定法 APELIN 风湿性心脏病
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