The grain boundary phase affects the magnetic properties and corrosion resistance of sintered NdFeB magnets.In this work,a small amount of In was added to NdFeB magnets by induction melting to systematically investiga...The grain boundary phase affects the magnetic properties and corrosion resistance of sintered NdFeB magnets.In this work,a small amount of In was added to NdFeB magnets by induction melting to systematically investigate its effect on the evolution of the microstructure,magnetic properties and corrosion resistance of NdFeB magnets.Microstructural analysis illustrated that minor In addition generated more grain boundary phases and an abundant amorphous phase at the triple-junction grain boundary.While the addition of In failed to enhance the magnetic isolation effect between adjacent matrix grains,its incorporation fortuitously elevated the electrochemical potential of the In-containing magnets.Besides,during corrosion,an In-rich precipitate phase formed,hindering the ingress of the corrosive medium into the magnet.Consequently,this significantly bolstered the corrosion resistance of the sintered NdFeB magnets.The phase formation,magnetic properties and corrosion resistance of In-doped NdFeB magnets are detailed in this work,which provides new prospects for the preparation of high-performance sintered NdFeB magnets.展开更多
The Joint United Nations program on HIV/AIDS reported that 53% of new infections globally in 2017 were beyond key populations and their sexual partners.In this report, although only 16% in Asia and the Pacific were pe...The Joint United Nations program on HIV/AIDS reported that 53% of new infections globally in 2017 were beyond key populations and their sexual partners.In this report, although only 16% in Asia and the Pacific were people living with HIV (PLHIV) who did not report any HIV-risk behaviors (mainly including injective drug use, men who have sex with men, sexual workers, and their dients), increasing diag no sed cases who reported their own transmission as non-marital and non-commercial heterosexual con tact (non-M&C sex, defi ned as those heterosexuals who have unpaid sex with any other sexual partners whom they have never married) in China have indicated that the HIV epidemic is spreading to the general population by the bridge of key populations.展开更多
With the rapid progress of urbanization,atmospheric fine particulate matter with an aerodynamic diameter of less than 2.5μm (PM_(2.5))has attracted increasing concern because of its hazardous effects as an air pollut...With the rapid progress of urbanization,atmospheric fine particulate matter with an aerodynamic diameter of less than 2.5μm (PM_(2.5))has attracted increasing concern because of its hazardous effects as an air pollutant on human health[1].展开更多
目的分析复方丹参滴丸联合单硝酸异山梨酯治疗冠心病心绞痛有效性及安全性。方法计算机检索中国知网、维普、万方、PubMed、Web of Science数据库,检索时限为自建库起至2023年2月28日,搜集相关临床随机对照试验(RCT),根据纳排标准选择R...目的分析复方丹参滴丸联合单硝酸异山梨酯治疗冠心病心绞痛有效性及安全性。方法计算机检索中国知网、维普、万方、PubMed、Web of Science数据库,检索时限为自建库起至2023年2月28日,搜集相关临床随机对照试验(RCT),根据纳排标准选择RCT,使用Review Manager 5.3软件进行meta分析。结果纳入14项RCT,meta分析结果显示,观察组的总有效率[OR=5.01,95%CI(3.39,7.42),P<0.00001]、心绞痛发作次数[MD=-1.75,95%CI(-2.43,-1.07),P<0.00001]、心绞痛发作持续时间[MD=-1.87,95%CI(-2.47,-1.26)、P<0.00001]、总胆固醇[MD=-0.96,95%CI(-1.19,-0.73),P<0.00001]、三酰甘油[MD=-0.52,95%CI(-0.65,-0.40),P<0.00001]、不良反应[OR=0.64,95%CI(0.43,0.97),P=0.03]均优于对照组。结论复方丹参滴丸联合单硝酸异山梨酯+常规西药治疗冠心病心绞痛临床疗效显著,安全性高,但需更多设计严谨的多样本、多中心、双盲RCT提供证据支持。展开更多
The anticancer potential of quassinoids has attracted a great deal of attention for decades,and scientific data revealing their possible applications in cancer management are continuously increasing in the literature....The anticancer potential of quassinoids has attracted a great deal of attention for decades,and scientific data revealing their possible applications in cancer management are continuously increasing in the literature.Aside from the potent cytotoxic and antitumor properties of these degraded triterpenes,several quassinoids have exhibited synergistic effects with anticancer drugs.This article provides an overview of the potential anticancer properties of quassinoids,including their cytotoxic and antitumor activities,mechanisms of action,safety evaluation,and potential benefits in combination with anticancer drugs.展开更多
Chronic diabetic wounds confront a significant medical challenge because of increasing prevalence and difficult-healing circumstances.It is vital to develop multifunctional hydrogel dressings,with well-designed morpho...Chronic diabetic wounds confront a significant medical challenge because of increasing prevalence and difficult-healing circumstances.It is vital to develop multifunctional hydrogel dressings,with well-designed morphology and structure to enhance flexibility and effectiveness in wound management.To achieve these,we propose a self-healing hydrogel dressing based on structural color microspheres for wound management.The microsphere comprised a photothermal-responsive inverse opal framework,which was constructed by hyaluronic acid methacryloyl,silk fibroin methacryloyl and black phosphorus quantum dots(BPQDs),and was further re-filled with a dynamic hydrogel.The dynamic hydrogel filler was formed by Knoevenagel condensation reaction between cyanoacetate and benzaldehyde-functionalized dextran(DEX-CA and DEX-BA).Notably,the composite microspheres can be applied arbitrarily,and they can adhere together upon near-infrared irradiation by leveraging the BPQDs-mediated photothermal effect and the thermoreversible stiffness change of dynamic hydrogel.Additionally,eumenitin and vascular endothelial growth factor were co-loaded in the microspheres and their release behavior can be regulated by the same mechanism.Moreover,effective monitoring of the drug release process can be achieved through visual color variations.The microsphere system has demonstrated desired capabilities of controllable drug release and efficient wound management.These characteristics suggest broad prospects for the proposed composite microspheres in clinical applications.展开更多
基金funded by Ningbo Key R&D Plan and“Unveiling and Leading”(Grant No.2023Z093)Ningbo Science and Technology Innovation 2025 Major Special Project(Grant No.2022Z106)Hezhou City Central Leading Local Science and Technology Development Special Fund Project(Grant No.HK ZY2022002).
文摘The grain boundary phase affects the magnetic properties and corrosion resistance of sintered NdFeB magnets.In this work,a small amount of In was added to NdFeB magnets by induction melting to systematically investigate its effect on the evolution of the microstructure,magnetic properties and corrosion resistance of NdFeB magnets.Microstructural analysis illustrated that minor In addition generated more grain boundary phases and an abundant amorphous phase at the triple-junction grain boundary.While the addition of In failed to enhance the magnetic isolation effect between adjacent matrix grains,its incorporation fortuitously elevated the electrochemical potential of the In-containing magnets.Besides,during corrosion,an In-rich precipitate phase formed,hindering the ingress of the corrosive medium into the magnet.Consequently,this significantly bolstered the corrosion resistance of the sintered NdFeB magnets.The phase formation,magnetic properties and corrosion resistance of In-doped NdFeB magnets are detailed in this work,which provides new prospects for the preparation of high-performance sintered NdFeB magnets.
基金supported by the Natural Science Foundation of China [71473234,71573239]
文摘The Joint United Nations program on HIV/AIDS reported that 53% of new infections globally in 2017 were beyond key populations and their sexual partners.In this report, although only 16% in Asia and the Pacific were people living with HIV (PLHIV) who did not report any HIV-risk behaviors (mainly including injective drug use, men who have sex with men, sexual workers, and their dients), increasing diag no sed cases who reported their own transmission as non-marital and non-commercial heterosexual con tact (non-M&C sex, defi ned as those heterosexuals who have unpaid sex with any other sexual partners whom they have never married) in China have indicated that the HIV epidemic is spreading to the general population by the bridge of key populations.
基金supported by grants from the National High-tech R&D Program [863 Program, 2014AA022001]the National Natural Science Foundation of China [Project#3107441]the Department of Education of Hubei Province[Q20191407]。
文摘With the rapid progress of urbanization,atmospheric fine particulate matter with an aerodynamic diameter of less than 2.5μm (PM_(2.5))has attracted increasing concern because of its hazardous effects as an air pollutant on human health[1].
文摘目的分析复方丹参滴丸联合单硝酸异山梨酯治疗冠心病心绞痛有效性及安全性。方法计算机检索中国知网、维普、万方、PubMed、Web of Science数据库,检索时限为自建库起至2023年2月28日,搜集相关临床随机对照试验(RCT),根据纳排标准选择RCT,使用Review Manager 5.3软件进行meta分析。结果纳入14项RCT,meta分析结果显示,观察组的总有效率[OR=5.01,95%CI(3.39,7.42),P<0.00001]、心绞痛发作次数[MD=-1.75,95%CI(-2.43,-1.07),P<0.00001]、心绞痛发作持续时间[MD=-1.87,95%CI(-2.47,-1.26)、P<0.00001]、总胆固醇[MD=-0.96,95%CI(-1.19,-0.73),P<0.00001]、三酰甘油[MD=-0.52,95%CI(-0.65,-0.40),P<0.00001]、不良反应[OR=0.64,95%CI(0.43,0.97),P=0.03]均优于对照组。结论复方丹参滴丸联合单硝酸异山梨酯+常规西药治疗冠心病心绞痛临床疗效显著,安全性高,但需更多设计严谨的多样本、多中心、双盲RCT提供证据支持。
基金supported by the National Natural Science Foundation of China(82274085)the Natural Science Foundation of Jiangsu Province(BK20220478)the Natural Science Foundation of Jiangsu Higher Education institutions of China(22KJB360010).
文摘The anticancer potential of quassinoids has attracted a great deal of attention for decades,and scientific data revealing their possible applications in cancer management are continuously increasing in the literature.Aside from the potent cytotoxic and antitumor properties of these degraded triterpenes,several quassinoids have exhibited synergistic effects with anticancer drugs.This article provides an overview of the potential anticancer properties of quassinoids,including their cytotoxic and antitumor activities,mechanisms of action,safety evaluation,and potential benefits in combination with anticancer drugs.
基金supported by the Ruijin Hospital Guangci Introducing Talent Projectfinancial support from National Natural Science Foundation of China(82372145)+4 种基金the Research Fellow(Grant No.353146)Research Project(347897)Solutions for Health Profile(336355)InFLAMES Flagship(337531)grants from Academy of Finlandthe Finland China Food and Health International Pilot Project funded by the Finnish Ministry of Education and Culture.
文摘Chronic diabetic wounds confront a significant medical challenge because of increasing prevalence and difficult-healing circumstances.It is vital to develop multifunctional hydrogel dressings,with well-designed morphology and structure to enhance flexibility and effectiveness in wound management.To achieve these,we propose a self-healing hydrogel dressing based on structural color microspheres for wound management.The microsphere comprised a photothermal-responsive inverse opal framework,which was constructed by hyaluronic acid methacryloyl,silk fibroin methacryloyl and black phosphorus quantum dots(BPQDs),and was further re-filled with a dynamic hydrogel.The dynamic hydrogel filler was formed by Knoevenagel condensation reaction between cyanoacetate and benzaldehyde-functionalized dextran(DEX-CA and DEX-BA).Notably,the composite microspheres can be applied arbitrarily,and they can adhere together upon near-infrared irradiation by leveraging the BPQDs-mediated photothermal effect and the thermoreversible stiffness change of dynamic hydrogel.Additionally,eumenitin and vascular endothelial growth factor were co-loaded in the microspheres and their release behavior can be regulated by the same mechanism.Moreover,effective monitoring of the drug release process can be achieved through visual color variations.The microsphere system has demonstrated desired capabilities of controllable drug release and efficient wound management.These characteristics suggest broad prospects for the proposed composite microspheres in clinical applications.
