AIM:To analyze the systemic factors including stroke history related to the retinal artery occlusion(RAO).METHODS:Patients with an exact diagnosis of RAO in the medical database of the Kailuan Corporation were identif...AIM:To analyze the systemic factors including stroke history related to the retinal artery occlusion(RAO).METHODS:Patients with an exact diagnosis of RAO in the medical database of the Kailuan Corporation were identified as the case group.Five patients without RAO were added for each case from the Kailuan Study and matched for sex and age(age±2)as the control group.The Kailuan Study is a general population-based cohort study in northern China,in which a total of 101510 individuals(81110 men)aged 18-98 y were recruited to participate in the study.And the participants were bi-annually reexamined.The database of both groups was from Kailuan study of 2010 cohort.All the information,including the demographic characteristics,lifestyle behaviors,medical comorbidities,medical history,family medical history,drug usage,anthropometric measurements,blood pressure measurement,blood sample laboratory assessment,urine tests,and other physical examinations were all collected.A retrospective nested case-control method was used for this study.Conditional multivariate logistic regression was used to analyze the risk factors with SPSS 13.0 software and SAS 9.3 software.RESULTS:A total of 45 patients were included as the case group,and the control group included 225 patients.In the case group,28 patients(62.2%)had a central retinal artery occlusion(CRAO),and 17 patients(37.8%)had a branch retinal artery occlusion(BRAO).A total of 18 patients(40.0%)had a stroke before the RAO(mean 4.04±3.88 y before the RAO),and 31 patients(81.6%)had infarctions or malacia identified by the cranial computed tomography(CT)scans.The basal ganglia and centrum semiovale were the most frequently involved regions.Plaques in the common carotid artery were present in 32 patients(88.9%).Conditional multivariate logistic regression analysis showed that the RAO was found to be associated with the history of stroke(P=0.0023,OR=28.794;95%CI:3.322-249.586).CONCLUSION:A history of stroke can significantly increase the incidence of RAO.Exists of plaque in the carotid artery is mean more than its severe stenosis for RAO.展开更多
紫丁香基木质素是一种重要的木质素,天然木质素也大多通过β-O-4键连接成网状结构,β-O-4型紫丁香基木质素二聚体模化物在前人研究的模化物基础上增加了多个甲氧基基团,更接近实际的紫丁香基木质素结构。在软件Materials Studio 2019的D...紫丁香基木质素是一种重要的木质素,天然木质素也大多通过β-O-4键连接成网状结构,β-O-4型紫丁香基木质素二聚体模化物在前人研究的模化物基础上增加了多个甲氧基基团,更接近实际的紫丁香基木质素结构。在软件Materials Studio 2019的Dmol3模块中,基于密度泛函理论利用B3LYP杂化泛函,对β-O-4型紫丁香基木质素二聚体模化物在875K、101kPa条件下的热解反应路径进行模拟,计算每步反应的反应物与生成物的焓值,并通过Vibration Analysis模块进行频率分析确认只有实频,没有虚频;计算每步反应的焓变并对反应路径总焓变进行比较,总焓变越小表明该路径在热力学上越容易发生,进而得到其较具优势的反应路径,最终得到对应路径的热解产物。结果表明,β-O-4型紫丁香基木质素二聚体模化物在875K、101kPa下的初步热解较有可能发生C_(α)—C_(β)键的断裂与β-O-4键的断裂,其中最可能发生β-O-4键的断裂;较具优势的反应路径包括总焓变为-59.65kJ/mol的R4、总焓变为-219.44 kJ/mol的R10、总焓变为-14.93kJ/mol的R12、总焓变为-389.29kJ/mol的R21、总焓变为-466.24kJ/mol的R23与总焓变为-276.72kJ/mol的R24,其中最具优势的路径为R21、R23与R24;热解的主要产物是邻苯三酚、3,4,5-三羟基苯甲醇、3,4,5-三羟基苯甲醛及乙醇,其中邻苯三酚、3,4,5-三羟基苯甲醇与乙醇为R21、R23与R24的热解产物。本研究得到的模拟结果可以为生成生物质焦的进一步模拟计算奠定基础。展开更多
基金教育部高等教育司2020年第二批产学合作协同育人项目“基于产学合作的大数据人才培养改革与实践”(编号:202002112009)江苏省高校哲学社会科学研究课题“基于多模态信息融合的网络舆情监测研究”(编号:2022SJYB0982)无锡学院2021年教学改革研究课题“计算机操作系统实验教程(基于Visual Studio 2019)”(编号:JGYB202107)。
基金Supported by National Natural Science Foundation of China(No.81570891,No.81272981)the Beijing Municipal Administration of Hospitals’Ascent Plan(No.DFL20150201)+4 种基金Beijing Natural Science Foundation(No.7151003)Advanced Health Care Professionals Development Project of Beijing Municipal Health Bureau(No.2014-2-003)Study on Individual Diagnosis and Therapy Strategy for Malignant Uveal Melanoma(No.20161-2051)Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(No.ZYLX201307)Science&Technology Project of Beijing Municipal Science&Technology Commission(No.Z151100001615052).
文摘AIM:To analyze the systemic factors including stroke history related to the retinal artery occlusion(RAO).METHODS:Patients with an exact diagnosis of RAO in the medical database of the Kailuan Corporation were identified as the case group.Five patients without RAO were added for each case from the Kailuan Study and matched for sex and age(age±2)as the control group.The Kailuan Study is a general population-based cohort study in northern China,in which a total of 101510 individuals(81110 men)aged 18-98 y were recruited to participate in the study.And the participants were bi-annually reexamined.The database of both groups was from Kailuan study of 2010 cohort.All the information,including the demographic characteristics,lifestyle behaviors,medical comorbidities,medical history,family medical history,drug usage,anthropometric measurements,blood pressure measurement,blood sample laboratory assessment,urine tests,and other physical examinations were all collected.A retrospective nested case-control method was used for this study.Conditional multivariate logistic regression was used to analyze the risk factors with SPSS 13.0 software and SAS 9.3 software.RESULTS:A total of 45 patients were included as the case group,and the control group included 225 patients.In the case group,28 patients(62.2%)had a central retinal artery occlusion(CRAO),and 17 patients(37.8%)had a branch retinal artery occlusion(BRAO).A total of 18 patients(40.0%)had a stroke before the RAO(mean 4.04±3.88 y before the RAO),and 31 patients(81.6%)had infarctions or malacia identified by the cranial computed tomography(CT)scans.The basal ganglia and centrum semiovale were the most frequently involved regions.Plaques in the common carotid artery were present in 32 patients(88.9%).Conditional multivariate logistic regression analysis showed that the RAO was found to be associated with the history of stroke(P=0.0023,OR=28.794;95%CI:3.322-249.586).CONCLUSION:A history of stroke can significantly increase the incidence of RAO.Exists of plaque in the carotid artery is mean more than its severe stenosis for RAO.
文摘紫丁香基木质素是一种重要的木质素,天然木质素也大多通过β-O-4键连接成网状结构,β-O-4型紫丁香基木质素二聚体模化物在前人研究的模化物基础上增加了多个甲氧基基团,更接近实际的紫丁香基木质素结构。在软件Materials Studio 2019的Dmol3模块中,基于密度泛函理论利用B3LYP杂化泛函,对β-O-4型紫丁香基木质素二聚体模化物在875K、101kPa条件下的热解反应路径进行模拟,计算每步反应的反应物与生成物的焓值,并通过Vibration Analysis模块进行频率分析确认只有实频,没有虚频;计算每步反应的焓变并对反应路径总焓变进行比较,总焓变越小表明该路径在热力学上越容易发生,进而得到其较具优势的反应路径,最终得到对应路径的热解产物。结果表明,β-O-4型紫丁香基木质素二聚体模化物在875K、101kPa下的初步热解较有可能发生C_(α)—C_(β)键的断裂与β-O-4键的断裂,其中最可能发生β-O-4键的断裂;较具优势的反应路径包括总焓变为-59.65kJ/mol的R4、总焓变为-219.44 kJ/mol的R10、总焓变为-14.93kJ/mol的R12、总焓变为-389.29kJ/mol的R21、总焓变为-466.24kJ/mol的R23与总焓变为-276.72kJ/mol的R24,其中最具优势的路径为R21、R23与R24;热解的主要产物是邻苯三酚、3,4,5-三羟基苯甲醇、3,4,5-三羟基苯甲醛及乙醇,其中邻苯三酚、3,4,5-三羟基苯甲醇与乙醇为R21、R23与R24的热解产物。本研究得到的模拟结果可以为生成生物质焦的进一步模拟计算奠定基础。
