目的应用静息态功能磁共振(resting state function magnetic resonance imaging,rs-fMRI)观察高压氧治疗(hyperbaric oxygen therapy,HBOT)对改善创伤性颅脑损伤(traumatic brain injury,TBI)患者执行功能(executive function,EF)的作...目的应用静息态功能磁共振(resting state function magnetic resonance imaging,rs-fMRI)观察高压氧治疗(hyperbaric oxygen therapy,HBOT)对改善创伤性颅脑损伤(traumatic brain injury,TBI)患者执行功能(executive function,EF)的作用。方法选取50例TBI后EF障碍患者,按照数字表法随机分为HBO组(n=25)和对照组(n=25),对照组接受常规基础治疗及EF康复训练,HBO组在对照组治疗的基础上加用HBO治疗,HBOT压力0.2 MPa,105 min/次,1次/d,5 d/周,共20次。所有受试者在治疗前后均应用画钟测验、中文版Stroop色词测验、韦氏成人智力量表相似性评分测验EF,同时采用rs-fMRI技术结合ReHo、ALFF分析方法,观察HBOT对TBI患者的大脑各区域代谢活动的强度、局部脑区神经元细胞同步性以及协调性改变情况,分析影像学数据与神经心理学量表评估结果的相关性。结果干预后2组间比较,HBO组Stroop-A耗时、Stroop-C耗时与正确阅读数及干扰效应评分改善程度明显优于对照组,差异有统计学意义(P<0.05)。不同干预后,2组TBI患者共同脑区在顶上小叶ALFF值差异有统计学意义(P<0.05)。相关性分析发现,HBO组差异脑区顶上小叶与干扰时间呈正相关(P<0.05)。HBO组差异脑区额中回与卡片A的正确阅读数呈正相关(P<0.05)。结论EF康复训练、HBO联合EF康复训练均能不同程度地改善TBI患者的EF;HBO联合EF康复训练对改善TBI患者的EF效果更好;HBOT改善TBI患者EF可能是通过调节额中回、顶上小叶脑区的自发活动及局部一致性而实现的。展开更多
The North Carnarvon Basin, which lies in the North West Shelf of Australia, is highly rich in gas resources. As a typical passive marginal basin, it experienced the pre-rifting, early rifting, main rifting, late rifti...The North Carnarvon Basin, which lies in the North West Shelf of Australia, is highly rich in gas resources. As a typical passive marginal basin, it experienced the pre-rifting, early rifting, main rifting, late rifting, post-rifting sagging and passive margin stages. The basin was mainly filled with thick Mesozoic-Cenozoic sediments, of which the Mesozoic hosts the principal source, reservoir and seal intervals. Mesozoic palaeogeography has an important control on the oil and gas distribution. Triassic gas-prone source rocks of deltaic origin deter-mine the high endowment of natural gases in the North Carnarvon Basin. The more restricted distribution of oil accumulations is controlled by oil source rocks in the Upper Jurassic Dingo Claystone. The Muderong Shale deposited in the Early Cretaceous marine transgression provides the effective regional seal for the underlying oil and gas reservoirs.展开更多
文摘目的应用静息态功能磁共振(resting state function magnetic resonance imaging,rs-fMRI)观察高压氧治疗(hyperbaric oxygen therapy,HBOT)对改善创伤性颅脑损伤(traumatic brain injury,TBI)患者执行功能(executive function,EF)的作用。方法选取50例TBI后EF障碍患者,按照数字表法随机分为HBO组(n=25)和对照组(n=25),对照组接受常规基础治疗及EF康复训练,HBO组在对照组治疗的基础上加用HBO治疗,HBOT压力0.2 MPa,105 min/次,1次/d,5 d/周,共20次。所有受试者在治疗前后均应用画钟测验、中文版Stroop色词测验、韦氏成人智力量表相似性评分测验EF,同时采用rs-fMRI技术结合ReHo、ALFF分析方法,观察HBOT对TBI患者的大脑各区域代谢活动的强度、局部脑区神经元细胞同步性以及协调性改变情况,分析影像学数据与神经心理学量表评估结果的相关性。结果干预后2组间比较,HBO组Stroop-A耗时、Stroop-C耗时与正确阅读数及干扰效应评分改善程度明显优于对照组,差异有统计学意义(P<0.05)。不同干预后,2组TBI患者共同脑区在顶上小叶ALFF值差异有统计学意义(P<0.05)。相关性分析发现,HBO组差异脑区顶上小叶与干扰时间呈正相关(P<0.05)。HBO组差异脑区额中回与卡片A的正确阅读数呈正相关(P<0.05)。结论EF康复训练、HBO联合EF康复训练均能不同程度地改善TBI患者的EF;HBO联合EF康复训练对改善TBI患者的EF效果更好;HBOT改善TBI患者EF可能是通过调节额中回、顶上小叶脑区的自发活动及局部一致性而实现的。
基金financially supported by National Science and Technology Major Project of the Chinese Ministry of Science and Technology (No.2011ZX05031-001-007HZ)
文摘The North Carnarvon Basin, which lies in the North West Shelf of Australia, is highly rich in gas resources. As a typical passive marginal basin, it experienced the pre-rifting, early rifting, main rifting, late rifting, post-rifting sagging and passive margin stages. The basin was mainly filled with thick Mesozoic-Cenozoic sediments, of which the Mesozoic hosts the principal source, reservoir and seal intervals. Mesozoic palaeogeography has an important control on the oil and gas distribution. Triassic gas-prone source rocks of deltaic origin deter-mine the high endowment of natural gases in the North Carnarvon Basin. The more restricted distribution of oil accumulations is controlled by oil source rocks in the Upper Jurassic Dingo Claystone. The Muderong Shale deposited in the Early Cretaceous marine transgression provides the effective regional seal for the underlying oil and gas reservoirs.
