According to our retrosynthesis, the main chain of the target molecule could be constructed using a C5 ＋ C7 ＋ C5 strategy. The key induction reaction afforded chiral methyl group moieties using different Evans templ...According to our retrosynthesis, the main chain of the target molecule could be constructed using a C5 ＋ C7 ＋ C5 strategy. The key induction reaction afforded chiral methyl group moieties using different Evans templates with different configurations. Li_2 Cu Cl_4was effectively employed in the Csp^3 Csp^3 coupling protocol. The target molecular was obtained in a 12.6% overall yield with nine steps in the longest linear route.展开更多
基金Financial support from the National Natural Science Foundation of China(No.31301712)
文摘According to our retrosynthesis, the main chain of the target molecule could be constructed using a C5 ＋ C7 ＋ C5 strategy. The key induction reaction afforded chiral methyl group moieties using different Evans templates with different configurations. Li_2 Cu Cl_4was effectively employed in the Csp^3 Csp^3 coupling protocol. The target molecular was obtained in a 12.6% overall yield with nine steps in the longest linear route.
