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Factors affecting complications development and mortality after single lung transplant 被引量:1
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作者 Metodija Sekulovski Bilyana Simonska +4 位作者 Milena Peruhova Boris Krastev Monika Peshevska-Sekulovska lubomir spassov Tsvetelina Velikova 《World Journal of Transplantation》 2021年第8期320-334,共15页
Lung transplantation(LT)is a life-saving therapeutic procedure that prolongs survival in patients with end-stage lung disease.Furthermore,as a therapeutic option for high-risk candidates,single LT(SLT)can be feasible ... Lung transplantation(LT)is a life-saving therapeutic procedure that prolongs survival in patients with end-stage lung disease.Furthermore,as a therapeutic option for high-risk candidates,single LT(SLT)can be feasible because the immediate morbidity and mortality after transplantation are lower compared to sequential single(double)LT(SSLTx).Still,the long-term overall survival is,in general,better for SSLTx.Despite the great success over the years,the early post-SLT period remains a perilous time for these patients.Patients who undergo SLT are predisposed to evolving early or late postoperative complications.This review emphasizes factors leading to post-SLT complications in the early and late periods including primary graft dysfunction and chronic lung allograft dysfunction,native lung complications,anastomosis complications,infections,cardiovascular,gastrointestinal,renal,and metabolite complications,and their association with morbidity and mortality in these patients.Furthermore,we discuss the incidence of malignancy after SLT and their correlation with immunosuppression therapy. 展开更多
关键词 Lung transplantation Single lung transplant Primary graft dysfunction Native lung complications Technical transplant complications Vascular transplant complications Graft rejection De novo malignancy
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