期刊文献+
共找到1篇文章
< 1 >
每页显示 20 50 100
Further Developments on the Regioselective Synthesis of 3-Aroylindole Derivatives from C-Nitrosoaromatics and Alkynones: A Novel Synthetic Approach to Pravadoline, JWH-073, Indothiazinone Analogues and Related Compounds
1
作者 luca scapinello Federico Vavassori +8 位作者 Gabriella Ieronimo Keshav L. Ameta Giancarlo Cravotto Marco Simonetti Stefano Tollari Giovanni Palmisano Kenneth M. Nicholas Andrea Penoni Angelo Maspero 《International Journal of Organic Chemistry》 CAS 2022年第3期127-142,共16页
An uncatalyzed and easily accessible synthetic approach for the preparation of 3-aroylindoles was investigated using nitrosoarenes and aromatic terminal ethynyl ketones. Indole derivatives were produced in good yields... An uncatalyzed and easily accessible synthetic approach for the preparation of 3-aroylindoles was investigated using nitrosoarenes and aromatic terminal ethynyl ketones. Indole derivatives were produced in good yields and excellent regioselectivity. Functionalizations of the indole products were carried out affording highly valuable and versatile compounds. The indolization protocol was studied as a fundamental step for the preparation of pravadoline and 1-butyl-3-(1-naphthoyl)indole (JWH-073), bioactive molecules showing antinociceptic properties. 展开更多
关键词 NITROSOARENES ALKYNONES INDOLES Cycoaddition ANNULATION
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部