In a recent study published in Nature,Shackelford and colleagues used an innovative in vivo mitochondrial morphology and bioenergetics analysis pipeline to correlate the metabolic signature of non-small cell lung canc...In a recent study published in Nature,Shackelford and colleagues used an innovative in vivo mitochondrial morphology and bioenergetics analysis pipeline to correlate the metabolic signature of non-small cell lung cancer subtypes to the ultrastructure of mitochondria and their contact sites with lipid droplets.This study paves the way for diagnostic and therapeutic protocols for lung cancer based on the rationale assessment and modulation of mitochondrial topology and ultrastructure.Mitochondria are dynamic bioenergetic structures adapting their morphology to the varying cellular pathophysiological conditions.展开更多
文摘In a recent study published in Nature,Shackelford and colleagues used an innovative in vivo mitochondrial morphology and bioenergetics analysis pipeline to correlate the metabolic signature of non-small cell lung cancer subtypes to the ultrastructure of mitochondria and their contact sites with lipid droplets.This study paves the way for diagnostic and therapeutic protocols for lung cancer based on the rationale assessment and modulation of mitochondrial topology and ultrastructure.Mitochondria are dynamic bioenergetic structures adapting their morphology to the varying cellular pathophysiological conditions.
