In recent decades,designers have increasingly focused on the stability of assemblies in composite materials over time,particularly when used in structural applications.The use of structural adhesives allows for realis...In recent decades,designers have increasingly focused on the stability of assemblies in composite materials over time,particularly when used in structural applications.The use of structural adhesives allows for realising assemblies without mechanical fasteners.In fact,bonding is an assembly technique that prevent corrosion,ensures uniform stresses in the joint,and grows the specific resistance of the assembly.The knowledge of the behaviour of bonded joint is necessary to ensure the reliability of this technique over time,especially in aggressive environments.The aim of this wo rk consists in investigating the combined effect of hydrothermal ageing and temperature test on the lap shear strength of single lap joints realised in CFRP.The results showed a higher influence of the ageing on paste adhesive compared to film adhesive.However,the ageing,combined with the operating temperature,played a fundamental role on the shear strength of the bonded joints.展开更多
About 30% of human breast cancers are human epidermal growth factor receptor 2(HER2)+. This particular biological portrait is characterized by the overexpression of HER2 receptor with the subsequent deregulation of do...About 30% of human breast cancers are human epidermal growth factor receptor 2(HER2)+. This particular biological portrait is characterized by the overexpression of HER2 receptor with the subsequent deregulation of downstream pathways, which control cellular survival and proliferation. The most effective treatment for HER2+cancer is represented by therapy with HER2-targeted agents. Anti-HER2 therapy dramatically improves clinical outcomes, although it shows some limitations in achieving a proper treatment. These drawbacks of HER2-targeted therapy may be overcome with the development of HER2-targeted drug delivery nanodevices. These nanoparticles possess an internal three-dimensional compartimentalization, which allows to combine the specific target recognition with their capability to act as a drug reservoir for the selective delivery of chemotherapics to tumor sites. Moreover, nanoparticles useful in photothermal ablation or in photodynamic therapy have been functionalized in order to match specificity in tumor cell recognition and suitable chemical properties. Here, we summarize the state of the art concerning the HER2+breast cancer and anti-HER2 therapy, in particular deepening the contribution of the nanomedicine. Description of preclinical studies performed with HER2-targeted na-noparticles for HER2+ breast cancer therapy will be preceded by an overview on HER2-targeting molecules and nano-conjugation strategies. Further investigation will be necessary to introduce these nano-drugs in clinical practice; however promising results encourage an upcoming translation of this research for the next future.展开更多
基金the funding of the Italian M.I.U.R.(Ministry of Instruction,University and Technological Research)。
文摘In recent decades,designers have increasingly focused on the stability of assemblies in composite materials over time,particularly when used in structural applications.The use of structural adhesives allows for realising assemblies without mechanical fasteners.In fact,bonding is an assembly technique that prevent corrosion,ensures uniform stresses in the joint,and grows the specific resistance of the assembly.The knowledge of the behaviour of bonded joint is necessary to ensure the reliability of this technique over time,especially in aggressive environments.The aim of this wo rk consists in investigating the combined effect of hydrothermal ageing and temperature test on the lap shear strength of single lap joints realised in CFRP.The results showed a higher influence of the ageing on paste adhesive compared to film adhesive.However,the ageing,combined with the operating temperature,played a fundamental role on the shear strength of the bonded joints.
文摘About 30% of human breast cancers are human epidermal growth factor receptor 2(HER2)+. This particular biological portrait is characterized by the overexpression of HER2 receptor with the subsequent deregulation of downstream pathways, which control cellular survival and proliferation. The most effective treatment for HER2+cancer is represented by therapy with HER2-targeted agents. Anti-HER2 therapy dramatically improves clinical outcomes, although it shows some limitations in achieving a proper treatment. These drawbacks of HER2-targeted therapy may be overcome with the development of HER2-targeted drug delivery nanodevices. These nanoparticles possess an internal three-dimensional compartimentalization, which allows to combine the specific target recognition with their capability to act as a drug reservoir for the selective delivery of chemotherapics to tumor sites. Moreover, nanoparticles useful in photothermal ablation or in photodynamic therapy have been functionalized in order to match specificity in tumor cell recognition and suitable chemical properties. Here, we summarize the state of the art concerning the HER2+breast cancer and anti-HER2 therapy, in particular deepening the contribution of the nanomedicine. Description of preclinical studies performed with HER2-targeted na-noparticles for HER2+ breast cancer therapy will be preceded by an overview on HER2-targeting molecules and nano-conjugation strategies. Further investigation will be necessary to introduce these nano-drugs in clinical practice; however promising results encourage an upcoming translation of this research for the next future.
