High resolution manometric findings in patients with Chagas' disease esophagopathy

Objective:To describe high resolution manometry features of a population of symptomatic- patients with Chagas’ disease esophagopathy(CDE).Methods:Sixteen symptomatic dysphagic patients with CDE[mean age(54.81±13.43) years,10 women]were included in this study.All patients underwent a high resolution manometry.Results:Mean lower esophageal sphincter(LES) extension was(3.02±1.17) cm with a mean basal pressure of(15.25±7.00) mmHg.Residual pressure was(14.31±9.19) mmHg.Aperistalsis was found in all 16 patients.Achalasia with minimal esophageal pressurization(type I) was present in 25%of patients and achalasia with esophageal compression(type 2) in 75%,according to the Chicago Classification.Upper esophageal sphincter(UES) mean basal pressure was(97.96±54.22) mmHg with a residual pressure of(12.95±6.42) mmHg.Conclusions:Our results show that LES was hypotensive or normotensive in the majority of the patients.Impaired relaxation was found in a minority of our patients.Aperistalsis was seen in 100%of patients.UES had impaired relaxation in a significant number of patients. Further clinical study is needed to investigate whether manometric features can predict outcomes following the studies of idiopathic achalasia..