Neuroendocrine tumors(NETs)encompass a broad spectrum of malignancies all derived from neuroendocrine cell lineage,affecting many different organs including the gastrointestinal(GI)tract,the endocrine pancreas,the thy...Neuroendocrine tumors(NETs)encompass a broad spectrum of malignancies all derived from neuroendocrine cell lineage,affecting many different organs including the gastrointestinal(GI)tract,the endocrine pancreas,the thyroid,the skin and the respiratory tract.These tumors as a group are very heterogeneous,with varying characteristics attributed to each tissue of origin and tumor subtype.The pathogenesis of the different subtypes of NETs is not fully understood,but recent studies suggest the Notch signaling pathway may be dysregulated in these tumors either by under or overexpression of Notch receptors and/or ligands,or by disruption of pathway functionality through other means.Notch receptors can function as tumor suppressors in some cellular contexts and oncogenes in others which may,in part,account for the wide range of phenotypes present in NETs.Cancer stem cells are present in these tumors and may be responsible for the high rate of chemotherapy resistance,recurrence and metastasis.The heterogeneity of NETs suggests that to fully understand the role of Notch signaling and the therapeutic implications thereof,a comprehensive and systematic analysis of Notch expression and function across all NET subtypes is required.Here we outline the current knowledge base with respect to current therapies and Notch signaling in neuroendocrine tumors of the lung,skin,thyroid,GI tract and endocrine pancreas.展开更多
It is my privilege to introduce the second issue of the Journal of Cancer Metastasis and Treatment.In keeping with the format we have chosen for our journal,this issue contains two reviews focusing on fields of great ...It is my privilege to introduce the second issue of the Journal of Cancer Metastasis and Treatment.In keeping with the format we have chosen for our journal,this issue contains two reviews focusing on fields of great translational and clinical interest,five original articles,and three case reports.The first review discusses the rapidly evolving field of circulating tumor cells(CTC)as cancer biomarkers.Since the introduction of the first Food and Drug Administration approved CTC test to assess the progression of metastatic breast,colorectal and prostate cancer,CTC have generated tremendous interest among clinicians seeking sensitive progression biomarkers and basic scientists interested in isolating and studying these cells.展开更多
基金supported by the Louisiana State University Health Science Center School of Medicine,Department of Genetics.
文摘Neuroendocrine tumors(NETs)encompass a broad spectrum of malignancies all derived from neuroendocrine cell lineage,affecting many different organs including the gastrointestinal(GI)tract,the endocrine pancreas,the thyroid,the skin and the respiratory tract.These tumors as a group are very heterogeneous,with varying characteristics attributed to each tissue of origin and tumor subtype.The pathogenesis of the different subtypes of NETs is not fully understood,but recent studies suggest the Notch signaling pathway may be dysregulated in these tumors either by under or overexpression of Notch receptors and/or ligands,or by disruption of pathway functionality through other means.Notch receptors can function as tumor suppressors in some cellular contexts and oncogenes in others which may,in part,account for the wide range of phenotypes present in NETs.Cancer stem cells are present in these tumors and may be responsible for the high rate of chemotherapy resistance,recurrence and metastasis.The heterogeneity of NETs suggests that to fully understand the role of Notch signaling and the therapeutic implications thereof,a comprehensive and systematic analysis of Notch expression and function across all NET subtypes is required.Here we outline the current knowledge base with respect to current therapies and Notch signaling in neuroendocrine tumors of the lung,skin,thyroid,GI tract and endocrine pancreas.
文摘It is my privilege to introduce the second issue of the Journal of Cancer Metastasis and Treatment.In keeping with the format we have chosen for our journal,this issue contains two reviews focusing on fields of great translational and clinical interest,five original articles,and three case reports.The first review discusses the rapidly evolving field of circulating tumor cells(CTC)as cancer biomarkers.Since the introduction of the first Food and Drug Administration approved CTC test to assess the progression of metastatic breast,colorectal and prostate cancer,CTC have generated tremendous interest among clinicians seeking sensitive progression biomarkers and basic scientists interested in isolating and studying these cells.
