Dear Editor, Fibroblast growth factors （FGFs） regulate a plethora of crit- ical processes in development （Beenken and Mohammadi, 2009）. These processes are mediated by signaling through four FGF receptors （FGFR1-...Dear Editor, Fibroblast growth factors （FGFs） regulate a plethora of crit- ical processes in development （Beenken and Mohammadi, 2009）. These processes are mediated by signaling through four FGF receptors （FGFR1-4）, which are high-affinity cell surface receptor tyrosine kinases. Receptors 1-3 undergo alternative splicing to generate b- and c-isoforms with altered ligand specificities and affinities. Ligand to receptor binding is not unique and one receptor can be activated by several FGFs. Heparan sulfate （HS） proteoglycan, a variably poly- sulfated glycosaminoglycan related to heparin, is an essential requirement for FGF signaling with FGFs varying in their specificities for different HS sulfation patterns （Galla- gher et al., 1992）.展开更多
文摘Dear Editor, Fibroblast growth factors （FGFs） regulate a plethora of crit- ical processes in development （Beenken and Mohammadi, 2009）. These processes are mediated by signaling through four FGF receptors （FGFR1-4）, which are high-affinity cell surface receptor tyrosine kinases. Receptors 1-3 undergo alternative splicing to generate b- and c-isoforms with altered ligand specificities and affinities. Ligand to receptor binding is not unique and one receptor can be activated by several FGFs. Heparan sulfate （HS） proteoglycan, a variably poly- sulfated glycosaminoglycan related to heparin, is an essential requirement for FGF signaling with FGFs varying in their specificities for different HS sulfation patterns （Galla- gher et al., 1992）.
