Non-alcoholic fatty liver disease(NAFLD)causes significant global disease burden and is a leading cause of mortality.NAFLD induces a myriad of aberrant changes in hepatocytes at both the cellular and molecular level.A...Non-alcoholic fatty liver disease(NAFLD)causes significant global disease burden and is a leading cause of mortality.NAFLD induces a myriad of aberrant changes in hepatocytes at both the cellular and molecular level.Although the disease spectrum of NAFLD is widely recognised,the precise triggers for disease progression are still to be fully elucidated.Furthermore,the propagation to cirrhosis is poorly understood.Whilst some progress in terms of treatment options have been explored,an incomplete understanding of the hepatic cellular and molecular alterations limits their clinical utility.We have therefore reviewed some of the key pathways responsible for the pathogenesis of NAFLD such as innate and adaptative immunity,lipotoxicity and fibrogenesis,and highlighted current trials and treatment options for NAFLD patients.展开更多
Alcoholic liver disease(ALD)due to chronic alcohol consumption is a significant global disease burden and a leading cause of mortality.Alcohol abuse induces a myriad of aberrant changes in hepatocytes at both the cell...Alcoholic liver disease(ALD)due to chronic alcohol consumption is a significant global disease burden and a leading cause of mortality.Alcohol abuse induces a myriad of aberrant changes in hepatocytes at both the cellular and molecular level.Although the disease spectrum of ALD is widely recognized,the precise triggers for disease progression are still to be fully elucidated.Oxidative stress,mitochondrial dysfunction,gut dysbiosis and altered immune system response plays an important role in disease pathogenesis,triggering the activation of inflammatory pathways and apoptosis.Despite many recent clinical studies treatment options for ALD are limited,especially at the alcoholic hepatitis stage.We have therefore reviewed some of the key pathways involved in the pathogenesis of ALD and highlighted current trials for treating patients.展开更多
文摘Non-alcoholic fatty liver disease(NAFLD)causes significant global disease burden and is a leading cause of mortality.NAFLD induces a myriad of aberrant changes in hepatocytes at both the cellular and molecular level.Although the disease spectrum of NAFLD is widely recognised,the precise triggers for disease progression are still to be fully elucidated.Furthermore,the propagation to cirrhosis is poorly understood.Whilst some progress in terms of treatment options have been explored,an incomplete understanding of the hepatic cellular and molecular alterations limits their clinical utility.We have therefore reviewed some of the key pathways responsible for the pathogenesis of NAFLD such as innate and adaptative immunity,lipotoxicity and fibrogenesis,and highlighted current trials and treatment options for NAFLD patients.
文摘Alcoholic liver disease(ALD)due to chronic alcohol consumption is a significant global disease burden and a leading cause of mortality.Alcohol abuse induces a myriad of aberrant changes in hepatocytes at both the cellular and molecular level.Although the disease spectrum of ALD is widely recognized,the precise triggers for disease progression are still to be fully elucidated.Oxidative stress,mitochondrial dysfunction,gut dysbiosis and altered immune system response plays an important role in disease pathogenesis,triggering the activation of inflammatory pathways and apoptosis.Despite many recent clinical studies treatment options for ALD are limited,especially at the alcoholic hepatitis stage.We have therefore reviewed some of the key pathways involved in the pathogenesis of ALD and highlighted current trials for treating patients.
