The human gut microbiota is composed of more than 100 trillion microbes.Most communities are dominated by species belonging to the phyla Bacteroidetes,Firmicutes,Actinobacteria,Proteobacteria,and Verrucomicrobia.Micro...The human gut microbiota is composed of more than 100 trillion microbes.Most communities are dominated by species belonging to the phyla Bacteroidetes,Firmicutes,Actinobacteria,Proteobacteria,and Verrucomicrobia.Microfl ora-derived short-chain fatty acids play a pivotal role in the framework of insulin resistance,obesity,and metabolic syndrome.They are an important energy source and are involved in several pathways,with proatherogenic and antiatherogenic effects.The increased gut microbiota lipopolysaccharide levels(defi ned as“metabolic endotoxemia”)induce a state of low-grade infl ammation and are involved in atherosclerotic disease through Toll-like receptor 4.Another important infl ammatory trigger in gut microbiota–mediated atherosclerotic promotion is trimethylamine N-oxide.On the other hand,protocatechuic acid was found to promote cholesterol effl ux from macrophages,showing an antiatherogenic effect.Further studies to clarify specifi c gut composition involved in cardiometabolic syndrome and atherogenesis are needed for greater use of targeted approaches.展开更多
文摘The human gut microbiota is composed of more than 100 trillion microbes.Most communities are dominated by species belonging to the phyla Bacteroidetes,Firmicutes,Actinobacteria,Proteobacteria,and Verrucomicrobia.Microfl ora-derived short-chain fatty acids play a pivotal role in the framework of insulin resistance,obesity,and metabolic syndrome.They are an important energy source and are involved in several pathways,with proatherogenic and antiatherogenic effects.The increased gut microbiota lipopolysaccharide levels(defi ned as“metabolic endotoxemia”)induce a state of low-grade infl ammation and are involved in atherosclerotic disease through Toll-like receptor 4.Another important infl ammatory trigger in gut microbiota–mediated atherosclerotic promotion is trimethylamine N-oxide.On the other hand,protocatechuic acid was found to promote cholesterol effl ux from macrophages,showing an antiatherogenic effect.Further studies to clarify specifi c gut composition involved in cardiometabolic syndrome and atherogenesis are needed for greater use of targeted approaches.
