Purines have a recognized importance as intercellular messengers.These molecules play an important role in the development and maintenance of the central nervous system(CNS),as well as in its response to pathological ...Purines have a recognized importance as intercellular messengers.These molecules play an important role in the development and maintenance of the central nervous system(CNS),as well as in its response to pathological conditions.Both adenine and guanine-based purines can be released from astrocytes,where they play a relevant role as extracellular signaling molecules.Particularly,the nucleoside guanosine has been proposed as an extracellular molecule展开更多
基金funding from Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq#403120/2012-8,#308723/2013-9,#449436/2014-4)Coordenacao de Aperfeicoamento de Pessoal de Nível Superior(CAPES),Brazil
文摘Purines have a recognized importance as intercellular messengers.These molecules play an important role in the development and maintenance of the central nervous system(CNS),as well as in its response to pathological conditions.Both adenine and guanine-based purines can be released from astrocytes,where they play a relevant role as extracellular signaling molecules.Particularly,the nucleoside guanosine has been proposed as an extracellular molecule
