Soil-transmitted helminth(STH)infections remain a significant global health burden,affecting over 1.5 billion people worldwide.In the Philippines,STH infections continue to be prevalent,despite ongoing control efforts...Soil-transmitted helminth(STH)infections remain a significant global health burden,affecting over 1.5 billion people worldwide.In the Philippines,STH infections continue to be prevalent,despite ongoing control efforts.The Integrated Helminth Control Program,whose cornerstone is the mass drug administration with benzimidazole drugs,has shown some success in reducing STH prevalence in the country.However,the persistence of infection prevalence being above the national and global targets and the potential for benzimidazole resistance have raised concerns about the long-term sustainability of current control strategies.This review examines the development of benzimidazole resistance in STH,focusing on the role of single nucleotide polymorphisms in theβ-tubulin isotype that alter the protein’s amino acid composition,thereby negatively affecting benzimidazole binding efficiency.This review discusses the epidemiology of STH infections in the Philippines,the implementation of the Integrated Helminth Control Program and the potential challenges posed by benzimidazole resistance.This review highlights the need for further research to assess the occurrence of benzimidazole resistance in Philippine STH populations and to explore alternative control strategies.Understanding the mechanisms of benzimidazole resistance and developing effective countermeasures is crucial for achieving sustainable STH control and elimination in the Philippines.展开更多
基金supported by the Postgraduate Scholarship for International Students of the Faculty of Medicine,Khon Kaen University(No.2577/2019)to JCBT and the Fundamental Fund of Khon Kaen University and the National Science,Research,and Innovation Fund to SS.The funders had no role in study design,data collection and analysis,decision to publish,or preparation of the manuscript.
文摘Soil-transmitted helminth(STH)infections remain a significant global health burden,affecting over 1.5 billion people worldwide.In the Philippines,STH infections continue to be prevalent,despite ongoing control efforts.The Integrated Helminth Control Program,whose cornerstone is the mass drug administration with benzimidazole drugs,has shown some success in reducing STH prevalence in the country.However,the persistence of infection prevalence being above the national and global targets and the potential for benzimidazole resistance have raised concerns about the long-term sustainability of current control strategies.This review examines the development of benzimidazole resistance in STH,focusing on the role of single nucleotide polymorphisms in theβ-tubulin isotype that alter the protein’s amino acid composition,thereby negatively affecting benzimidazole binding efficiency.This review discusses the epidemiology of STH infections in the Philippines,the implementation of the Integrated Helminth Control Program and the potential challenges posed by benzimidazole resistance.This review highlights the need for further research to assess the occurrence of benzimidazole resistance in Philippine STH populations and to explore alternative control strategies.Understanding the mechanisms of benzimidazole resistance and developing effective countermeasures is crucial for achieving sustainable STH control and elimination in the Philippines.
