Dear Editor,MicroRNAs(miRNAs)are small non-coding RNAs crucial for post-transcriptional gene regulation,processed from primary miRNA transcripts by Drosha and Dicer.1 Latest advancements in Next Generation Sequencing ...Dear Editor,MicroRNAs(miRNAs)are small non-coding RNAs crucial for post-transcriptional gene regulation,processed from primary miRNA transcripts by Drosha and Dicer.1 Latest advancements in Next Generation Sequencing highlighted the existence of miRNA isoforms(isomiRs)resulting from alternative processing,RNA editing,or post-transcriptional modifications.展开更多
Dear Editor,Programmed cell death protein 1(PD-1;encoded by the PDCD1 gene),mostly expressed on activated T cells,is an important receptor in T-cell immunity.1–3 Together with programmed deathligand 1(PD-L1:encoded b...Dear Editor,Programmed cell death protein 1(PD-1;encoded by the PDCD1 gene),mostly expressed on activated T cells,is an important receptor in T-cell immunity.1–3 Together with programmed deathligand 1(PD-L1:encoded by the CD274 gene)PD-1 acts as an inhibitor of T cell activity under normal conditions.展开更多
基金The authors thank the Genomics Shared Resource at The Ohio State University Comprehensive Cancer Center(OSU CCC),Columbus,OH.This work was supported by the NCI(NIH)grant R35CA197706 to C.M.Croce.
文摘Dear Editor,MicroRNAs(miRNAs)are small non-coding RNAs crucial for post-transcriptional gene regulation,processed from primary miRNA transcripts by Drosha and Dicer.1 Latest advancements in Next Generation Sequencing highlighted the existence of miRNA isoforms(isomiRs)resulting from alternative processing,RNA editing,or post-transcriptional modifications.
基金This work was supported by the R35CA197706 grant from the National Institutes of Health to CMC。
文摘Dear Editor,Programmed cell death protein 1(PD-1;encoded by the PDCD1 gene),mostly expressed on activated T cells,is an important receptor in T-cell immunity.1–3 Together with programmed deathligand 1(PD-L1:encoded by the CD274 gene)PD-1 acts as an inhibitor of T cell activity under normal conditions.
