A highly enantioselective palladium-catalyzed intramolecular Heck reaction of unactivated alkenes is developed,which provides a powerful route to access a broad range of chiral 3,3-disubstituted-2,3-dihydrobenzofurans...A highly enantioselective palladium-catalyzed intramolecular Heck reaction of unactivated alkenes is developed,which provides a powerful route to access a broad range of chiral 3,3-disubstituted-2,3-dihydrobenzofurans bearing all-carbon quaternary stereocenter of interest in pharmaceutical research.Its salient features include high yield,excellent chemo-and enantioselectivity,mild conditions,a broad substrate scope as well as versatile transformations of the product.展开更多
A gold(Ⅰ)-catalyzed asymmetric intermolecular tandem[3+3]-cyclization reaction of 2-(l-alkynyl)-2-alken-l-ones with nitrones has been developed by using Ming-Phos as a chiral ligand.This method enables access to the ...A gold(Ⅰ)-catalyzed asymmetric intermolecular tandem[3+3]-cyclization reaction of 2-(l-alkynyl)-2-alken-l-ones with nitrones has been developed by using Ming-Phos as a chiral ligand.This method enables access to the stereodivergent synthesis of highly substituted furo[3,4-d][l,2]oxazines in excellent efficiency and stereoselectivity(up to 99% yield,99% ee,>20:1 dr).展开更多
基金support of the National Key R&D Program of China(No.2021YFF0701600),NSFC(No.22031004)the Shanghai Municipal Education Commission(No.20212308)China Postdoctoral Science Foundation(No.2022M713667)and STCSM(No.23ZR1445600).
文摘A highly enantioselective palladium-catalyzed intramolecular Heck reaction of unactivated alkenes is developed,which provides a powerful route to access a broad range of chiral 3,3-disubstituted-2,3-dihydrobenzofurans bearing all-carbon quaternary stereocenter of interest in pharmaceutical research.Its salient features include high yield,excellent chemo-and enantioselectivity,mild conditions,a broad substrate scope as well as versatile transformations of the product.
基金the fundi ng support of NSFC(Nos.21425205,21672067,21801078)973 Program(No.2015CB856600)the Program of Eastern Scholar at Shanghai Institutions of Higher Learning and the China Postdoctoral Science Foundation(Nos.2019M650071,2019M661418).
文摘A gold(Ⅰ)-catalyzed asymmetric intermolecular tandem[3+3]-cyclization reaction of 2-(l-alkynyl)-2-alken-l-ones with nitrones has been developed by using Ming-Phos as a chiral ligand.This method enables access to the stereodivergent synthesis of highly substituted furo[3,4-d][l,2]oxazines in excellent efficiency and stereoselectivity(up to 99% yield,99% ee,>20:1 dr).
