Research Progress in Surface and Marine Gravimetry

Gravity field is the most basic physical field generated by the material properties of the Earth system.It reflects the spatial distribution,movement and change of materials determined by the interaction and dynamic process inside the Earth.Over the years,a variety of technical means have been used to detect the Earth’s gravity field and supported numerous studies on the global change,resource detection,geological structure movement,water resources change and other related fields of research.Here is part of the progress in surface and marine gravimetry obtained by Chinese geodesy scientists from 2019 to 2023 from the following aspects,including:①Continuous gravity network in Chinese mainland;②Application of superconducting gravity measurement;③Network adjustment for continental-scale gravity survey campaign and data quality control;④Regional time-variable gravity field and its application;⑤Research progress on novel technologies for gravity inversion;⑥Research progress on marine gravity field determination;⑦Application research on marine gravity field.

Effects of Three Commonly-used Diuretics on the Urinary Proteome

Biomarker is the measurable change associated with a physiological or pathophysiological process. Unlike blood which has mechanisms to keep the internal environment homeostatic, urine is more likely to reflect changes of the body. As a result, urine is likely to be a better biomarker source than blood. However, since the urinary proteome is affected by many factors, including diuretics, careful evaluation of those effects is necessary if urinary proteomics is used for biomarker discovery. Here, we evaluated the effects of three commonly-used diuretics （furosemide, F; hydrochlorothiazide, H; and spirolactone, S） on the urinary proteome in rats. Urine samples were collected before and after intragastric administration of diuretics at therapeutic doses and the proteomes were analyzed using label-free liquid chromatography-tandem mass spectrometry （LC-MS/MS）. Based on the criteria of P ≤ 0.05, a fold change ≥2, a spectral count ≥ 5, and false positive rate （FDR） ≤1%, 14 proteins （seven for F, five for H, and two for S） were identified by Progenesis LC-MS. The human orthologs of most of these 14 proteins are stable in the healthy human urinary proteome, and ten of them are reported as disease biomarkers. Thus, our results suggest that the effects of diuretics deserve more attention in future urinary protein biomarker studies. Moreover, the distinct effects of diuretics on the urinary proteome may provide clues to the mechanisms of diuretics.