Task Assignment Problem of Robots in a Smart Warehouse Environment

The task assignment problem of robots in a smart warehouse environment （TARSWE） based on cargo-to-person is investigated. Firstly, the sites of warehouse robots and the order picking tasks are given and the task assignment problem for picking one order is formulated into a mathematical model to minimize the total operation cost. Then a heuristic algorithm is designed to solve the task assignment problem for picking multiple orders. Finally, simulations are done by using the orders data of online bookstore A. The results show that using the heuristic algorithm of this paper to assign robots, the cost was reduced by 2% and it can effectively avoid far route and unbalanced workload of robots. The feasibility and validity of the model and algorithm are verified. The model and algorithm in this paper provide a theoretical basis to solve the TARSWE.

人口神经科学数据共享:政策生态、基础设施、实践和挑战

随着开放科学时代的到来,全球的数据共享政策日趋完善,科学数据共享逐步成为学术交流的必选项.科研模式及学术交流模式正发生着深刻的变革,如何让科学数据开放共享可持续发展,依然面临着来自文化、政策与实践路径上的现实阻力和挑战.本文梳理了科学数据开放共享可持续发展的必要组成及彼此间的作用关系,分析了利益相关方在数据共享中的诉求与需要付诸的投入.接着,从各方主体的科学数据共享政策情况、科学数据共享的标准及原则、数据存储库的标准规范指南、人口神经科学领域数据存储平台建设实践情况等方面,结合我国“科学数据银行:中国人彩巢计划数据社区”进行具体介绍与特征分析.人口神经科学领域的快速发展在很大程度上得益于科学数据共享,但依然面临着来自隐私安全与伦理,数据共享激励机制缺失,科研群体科学数据管理素质不足等突出问题和挑战.其中,伴随着新型科学技术的发展,隐私安全正被不断地完善和保护.针对科学数据共享的发展现状及挑战,本文基于在数据共享的政策、建立激励机制、基础设施建设、跨学科融合发展等方面的研究提出人口神经科学在科学数据共享工作上的未来发展趋势与建议.

Aerodynamic/control integrated optimization method for unpowered high-speed vehicle configuration design

The unpowered high-speed vehicle experiences a significant coupling between the disciplines of aerodynamics and control due to its characteristics of high flight speed and extensive maneuverability within large airspace.The conventional aircraft conceptual design process follows a sequential design approach,and there is an artificial separation between the disciplines of aerodynamics and control,neglecting the coupling effects arising from their interaction.As a result,this design process often requires extensive iterations over long periods when applied to high-speed vehicles,and may not be able to effectively achieve the desired design objectives.To enhance the overall performance and design efficiency of high-speed vehicles,this study integrates the concept of Active Control Technology(ACT)from modern aircraft into the philosophy of aerodynamic/control integrated optimization.Two integrated optimization strategies,with differences in coupling granularity,have been developed.Subsequently,these strategies are put into action on a biconical vehicle that operates at Mach 5.The results reveal that the comprehensive performance of the synthesis optimal model derived from the aerodynamic/control integrated optimization strategy is improved by 31.76%and 28.29%respectively compared to the base model under high-speed conditions,demonstrating the feasibility and effectiveness of the method and optimization strategies employed.Moreover,in comparison to the single-stage strategy,the multi-stage strategy takes into deeper consideration the impact of control capacity.As a result,the control performance of the synthesis opti-mal model derived from the multi-stage strategy improves by 13.99%,whereas the single-stage strategy only achieves a 5.79%improvement.This method enables a fruitful interaction between aerodynamic configuration design and control system design,leading to enhanced overall performance and design efficiency.Furthermore,it improves the controllability of high-speed vehicles,mitigating the risk of mission failure resulting from an ineffective control system.

Corrigendum to“Absence of Serpinb6a causes progressive hair cell apoptosis and hearing loss in mice”[Journal of Genetics and Genomics(2023)50,122-125]

This corrigendum clarifies information in the article"Absence of Serpinb6a causes progressive hair cell apoptosis and hearing loss in mice"by Cheng et al.(2023).In the author list,the author"Cheng Cheng"should be corrected into"Cheng Cheng".

Absence of Serpinb6a causes progressive hair cell apoptosis and hearing loss in mice

Hearing impairment constitutes a global public health problem with severe social,political,and economic consequences,and the World Health Organization estimates that about 466 million individuals globally have some degree of hearing loss.Genetic factors account for about half of all deafness cases.Currently,more than 100 genes are known to be involved in hearing loss,but the underlying molecular mechanisms behind these deafness genes have not been fully characterized.The main clinical treatment for deafness is hearing aids and cochlear implants,but their efficacy depends heavily on the quantity and quality of residual hair cells(HCs)and spiral ganglion neurons and has only limited auditory effects.

Mid-infrared chemical imaging of intracellular tau fibrils using fluorescence-guided computational photothermal microscopy

Amyloid proteins are associated with a broad spectrum of neurodegenerative diseases.However,it remains a grand challenge to extract molecular structure information from intracellular amyloid proteins in their native cellular environment.To address this challenge,we developed a computational chemical microscope integrating 3D midinfrared photothermal imaging with fluorescence imaging,termed Fluorescence-guided Bond-Selective Intensity Diffraction Tomography(FBS-IDT).Based on a low-cost and simple optical design,FBS-IDT enables chemical-specific volumetric imaging and 3D site-specific mid-IR fingerprint spectroscopic analysis of tau fbrils,an important type of amyloid protein aggregates,in their intracellular environment.Label-free volumetric chemical imaging of human cells with/without seeded tau fibrils is demonstrated to show the potential correlation between lipid accumulation and tau aggregate formation.Depth-resolved mid-infrared fingerprint spectroscopy is performed to reveal the protein secondary structure of the intracellular tau fibrils.3D visualization of theβ-sheet for tau fibril structure is achieved.

Effect of Different Geometric Porosities on Aerodynamic Characteristics of Supersonic Parachutes

The supersonic parachute plays an important role in the descent and landing of Mars missions.Next-generation supersonic parachutes,such as disksail parachutes,are alternatives to disk-gap-band(DGB)parachutes.Disksail parachutes have larger porous gaps and smaller porous seams on the canopy surface than DGB parachutes.To date,the influence mechanism of porous seams or gaps and their locations on the performance of supersonic parachute systems in Martian atmospheric conditions remains unclear.In this study,different canopy models with seams and gaps based on NASA’s supersonic disksail parachutes were designed,and the aerodynamic characteristics of such geometric porosity models were studied numerically.For seam-only models,the drag coefficient of the parachute decreases when the position of the seam is close to the middle of the canopy.When the seam is close to the mouth of the canopy,the pressure difference between the inner and outer surface of the canopy becomes small,reducing the risk of tearing the canopy.For gap-only models,the drag coefficient of the middle gap model is higher,while the lateral force stability of the top gap model is better.The results show that the addition of a seam can improve the drag performance of the top gap model and improve the lateral stability of the canopy with the middle gap.This study provides some theoretical references for designing the porosity of parachutes under different requirements for Mars exploration missions in the future.

I3:A Self-organising Learning Workflow for Intuitive Integrative Interpretation of Complex Genetic Data

We propose a computational workflow(I3)for intuitive integrative interpretation of complex genetic data mainly building on the self-organising principle.We illustrate the use in interpreting genetics of gene expression and understanding genetic regulators of protein phenotypes,particularly in conjunction with information from human population genetics and/or evolutionary history of human genes.We reveal that loss-of-function intolerant genes tend to be depleted of tissue-sharing genetics of gene expression in brains,and if highly expressed,have broad effects on the protein phenotypes studied.We suggest that this workflow presents a general solution to the challenge of complex genetic data interpretation.I3 is available at http://suprahex.r-forge.r-project.org/I3.html.

Simultaneous bioimaging of MMP-2 and MMP-7 via Au-Se constructed fluorescence nanoprobe

Au-Se bond strategy has been applied to construct fluorescence nanoprobe that is being used to simultaneously dual-image the tumor markers matrix metalloproteinase-2(MMP-2)and matrix metalloproteinase-7(MMP-7)in vitro.The two Se-terminating ligand peptide chains respectively labeled with fluorescein isothiocyanate(FITC)and 5-Carboxytetramethylrhodamine(5-TAMRA)dyes are attached to the surface of Au nanoparticles(NPs).The nanoprobe can be specifically cut off by MMP-2 and MMP-7 respectively to carry out significant enhanced fluorescence recovery for simultaneously imaging both markers.The nanoprobe not only displays high selectivity and sensitivity towards MMP-2 and MMP-7,but also has strong anti-interference stability against biothiols and enhanced fidelity for avoiding"false positive"results.This approach offers new perspectives in designing tumor-related early diagnosis approaches and also provides strategies for clinical applications.

Numerical Study on Aerodynamic Performance of Mars Parachute Models with Geometric Porosities

The supersonic flows around rigid parachute-like two-body configurations are numerically simulated at Mach number of 1.978 by solving three-dimensional compressible Navier-Stokes equations,where the two-body model consists of a capsule and a canopy,and a geometric structure(i.e.,gap)is located on the canopy surface.The objective of this study is to investigate the effects of gaps with different porosities and positions on the aerodynamic performance of supersonic parachute.The complicated periodic aerodynamic interactions between the capsule wake and canopy shock occur around these two-body models.From the formation of canopy shock and drag coefficient variation,the cycled flow structures can be divided into three types:(1)narrow wake period,(2)open wake period,and(3)middle wake period.In addition,it was found that the geometric gaps have no obvious influences on the flow modes.However,compared with models with different gap positions,the two-body model with an upper gap(gap is close to the canopy vent,UG model)has a smaller drag coefficient fluctuation and better lateral stability.On the other side,the increase of porosity has a more significant impact on UG models.