Background:Endothelial keratoplasty(EK)is used increasingly for the management of cases with endothelial dysfunction.Long-term outcomes of the surgery are not widely reported in the literature.We report our experience...Background:Endothelial keratoplasty(EK)is used increasingly for the management of cases with endothelial dysfunction.Long-term outcomes of the surgery are not widely reported in the literature.We report our experience of EK in Chinese eyes at a University teaching hospital.Methods:Retrospective analysis was performed for all cases of EK performed between 2005 and 2009.Data analyzed included indication for surgery,associated surgical procedures,complications,best-corrected visual acuity(BCVA)and overall graft survival.Results:Overall,22 eyes of 21 patients underwent EK(13 males,8 females,mean age 71.8±11.3 years).Pseudophakic bullous keratopathy was the leading indication for surgery(n=12)followed by Fuchs’endothelial dystrophy(n=4),or both(n=3).Other indications for surgery included failed penetrating keratoplasty(n=2)and endothelial decompensation due to multiple surgeries(n=1).Triple procedure was performed in 5(22.7%)cases.Complications were noted in the form of postoperative interface hemorrhage(n=2,9%)and graft dislocation(n=1,4.5%).The mean postoperative endothelial cell density was 1069±585.8 cells/mm2.The mean postoperative pachymetry was 675.8±108.5μm.The mean preoperative and postoperative intraocular pressure was 11.3±3.2 and 13.9±4.5 mmHg respectively.At the last follow-up(mean,47.4±13.7 months),BCVA was≥20/70 in 9(40.9%)cases.Causes of poor BCVA included primary graft failure(n=4),graft decompensation(n=4),advanced glaucoma(n=2)and irreversible graft rejection(n=2).Graft remained clear in 12(54.5%)cases at the last follow-up.Average graft survival was 19.7±17.7 months(median 17.5 months).Conclusions:Nearly half of the EK grafts in our study survived over a period of five years.Graft failure,glaucoma and graft rejection were the main causes of poor graft survival.展开更多
文摘Background:Endothelial keratoplasty(EK)is used increasingly for the management of cases with endothelial dysfunction.Long-term outcomes of the surgery are not widely reported in the literature.We report our experience of EK in Chinese eyes at a University teaching hospital.Methods:Retrospective analysis was performed for all cases of EK performed between 2005 and 2009.Data analyzed included indication for surgery,associated surgical procedures,complications,best-corrected visual acuity(BCVA)and overall graft survival.Results:Overall,22 eyes of 21 patients underwent EK(13 males,8 females,mean age 71.8±11.3 years).Pseudophakic bullous keratopathy was the leading indication for surgery(n=12)followed by Fuchs’endothelial dystrophy(n=4),or both(n=3).Other indications for surgery included failed penetrating keratoplasty(n=2)and endothelial decompensation due to multiple surgeries(n=1).Triple procedure was performed in 5(22.7%)cases.Complications were noted in the form of postoperative interface hemorrhage(n=2,9%)and graft dislocation(n=1,4.5%).The mean postoperative endothelial cell density was 1069±585.8 cells/mm2.The mean postoperative pachymetry was 675.8±108.5μm.The mean preoperative and postoperative intraocular pressure was 11.3±3.2 and 13.9±4.5 mmHg respectively.At the last follow-up(mean,47.4±13.7 months),BCVA was≥20/70 in 9(40.9%)cases.Causes of poor BCVA included primary graft failure(n=4),graft decompensation(n=4),advanced glaucoma(n=2)and irreversible graft rejection(n=2).Graft remained clear in 12(54.5%)cases at the last follow-up.Average graft survival was 19.7±17.7 months(median 17.5 months).Conclusions:Nearly half of the EK grafts in our study survived over a period of five years.Graft failure,glaucoma and graft rejection were the main causes of poor graft survival.
