血脂与双侧突发性聋发病及预后的临床分析

目的对24例双侧突发性聋临床资料分析,探讨血脂与双侧突发性聋听力损失程度及预后的关系。方法对24例(48耳)双侧突聋与同期239例单侧突聋的临床资料进行回顾性研究,观察血脂[总胆固醇(TC),甘油三酯(TG),高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)]与突发性聋听力损失程度及预后恢复的关系。结果双侧突聋患者的治愈率为0,总有效率为12.5%。双侧突聋患者的听力下降程度与TG升高水平有正相关性(P=0.021)。血脂水平和突聋的听力曲线无相关性;无效组患者TG平均水平较有效组患者更高(P=0.032),无效组患者LDL-C平均水平较有效组患者更高(P=0.041)。在单侧突聋组,TC平均水平在治愈组最低,在无效组、有效组、显效组明显升高(P=0.018);LDL-C平均水平在治愈组、显效组明显低于有效组及无效组(P=0.035)。结论双侧突聋的预后更差;TG与双侧突聋患者听力下降程度呈正相关性,TG、LDL-C与双侧突聋患者的治疗总有效率呈负相关性。TC与单侧突聋患者听力下降程度呈正相关性,LDL-C与单侧突聋患者的治疗有效率呈负相关性。

Synthesis, crystal structure and thermal analysis of a new stilbazolium salt crystal

A new organic crystal of 4-N, N-dimethylamino-4＇-N＇-methyl-stilbazolium benzene sulfonate （DASBS） was synthesized and characterized for the first time. It is a derivative of 4-N, N-dimethylamino-4＇-N＇-methyl-stilbazolium tosylate （DAST） with the benzene sulfonate replacing p-toluenesulfonate. Single crystal XRD demonstrated that the crystal structure of DASBS. H20 was triclinic. The thermal analysis of this new crystal was also conducted, and the melting point was obtained to be 232℃.