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成人NUP98融合基因阳性AML患者的临床特点及生物学特征 被引量:5
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作者 伦燕 黄菁草 +6 位作者 龙丹 王方芳 代阳 杨艳 赵婷婷 李清 吴俣 《四川大学学报(医学版)》 CAS CSCD 北大核心 2018年第4期575-581,共7页
目的探讨成人急性髓细胞白血病(AML)患者中核孔蛋白98(NUP98)融合基因阳性患者的临床特点及生物学特征,以及NUP98融合基因与AML常见融合基因、预后基因的共表达对AML预后的影响。方法收集四川大学华西医院2014年7月1日至2017年3月1日间... 目的探讨成人急性髓细胞白血病(AML)患者中核孔蛋白98(NUP98)融合基因阳性患者的临床特点及生物学特征,以及NUP98融合基因与AML常见融合基因、预后基因的共表达对AML预后的影响。方法收集四川大学华西医院2014年7月1日至2017年3月1日间住院的成人初发AML和骨髓增生异常综合征(MDS)患者的骨髓或外周血标本,检测NUP98融合基因,并检测AML患者染色体核型。将染色体11p15重排或NUP98相关融合基因阳性的AML患者作为研究组,此期间初诊的其余AML患者作为对照组,并将其分为低、中、高危对照组。通过对照研究,分析其血液学特点、完全缓解率(CR)、与预后基因的共表达率以及生存分析。结果样本总量为197例。共16例(8.1%)患者存在NUP98相关融合基因(即研究组),发现我院首例NUP98-拓扑异构酶Ⅰ(TOP1)融合基因阳性AML。研究组患者按FAB分型,主要为M2和M5;研究组Fms样酪氨酸激酶-3(FLT3)-基因内部串联重复突变(ITD)发生率[31.25%(5/16)]和死亡率[80.00%(4/5)]高于对照组[发生率9.95%(19/181),死亡率42.11%(8/19),P<0.05];研究组诱导化疗获CR率为78.57%,高于总对照组及其中高、中危亚组(P<0.05)。研究组中位总生存期(OS)为13月,中位无白血病生存期(LFS)仅为5月。结论NUP98融合基因阳性AML易合并其它融合基因及预后基因的共表达,LFS和OS较短,尤其发生FLT3-ITD共表达时,死亡率高。 展开更多
关键词 急性髓细胞白血病 NUP98-HOXA9 NUP98-NSD1 NUP98-TOP1 FLT3-ITD
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Study of a damage constitutive model for water-bearing coal measures sedimentary rock with nonlinear deformation during compaction stage
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作者 Weinan Wang Qiangling Yao +5 位作者 Aiwen Wang Karen A.Hudson-Edwards Chuangkai Zheng lun yan Lianpeng Dai Yihong Liu 《Geohazard Mechanics》 2023年第3期244-254,共11页
The problem of repeated immersion-induced fatigue damage in engineering coal measures sedimentary rock,including coal-rock pillars,reservoir bank slopes,and water-rich tunnels at the boundary of coal mine underground ... The problem of repeated immersion-induced fatigue damage in engineering coal measures sedimentary rock,including coal-rock pillars,reservoir bank slopes,and water-rich tunnels at the boundary of coal mine underground reservoirs,has profound implications for their stability,safety,and operation,and can even lead to geological disasters.To address this issue,this paper aims to construct a constitutive model that accurately captures the comprehensive process of deformation and failure in water-bearing coal measures sedimentary rock.It explores the deformation characteristics of these formations and provides a theoretical foundation for numerical simulations of geological disasters induced by water-rock interaction.This study integrates the deformation mechanisms of void and matrix deformation in coal seam sedimentary rocks,while considering the influence of immersion cycles.Subsequently,it formulates a segmented constitutive model to depict the entire process of deformation and failure in cyclically immersed water-bearing coal measures sedimentary rock under uniaxial compression.The proposed model's accuracy and rationality are validated through comparisons with experimental research findings and existing theoretical curves from similar models.The results demonstrate the model's effectiveness in describing the deformation behavior of non-dense water-bearing coal measures sedimentary rock under uniaxial compression or low confining pressure before reaching peak stress,although further refinements may be necessary to precisely capture post-peak deformation characteristics.Model parameters,including the deformation caused by voids(γ0)between voids,increase exponentially with immersion times,while the elastic modulus(Ev)of voids and the parameter(F0)related to the average strength of microelements decrease exponentially.The homogeneity degree(m)exhibits no discernible pattern.These research outcomes provide valuable insights for the stability control of engineering coal measures sedimentary rock under water-rock interaction and the mitigation of related geological disasters. 展开更多
关键词 Cyclic immersion Water-rock interaction Void compaction Deformation characteristic Constitutive model
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