移动媒体受众新闻消费多样性演化研究

本研究基于2019年7月1日至2019年12月31日某移动新闻媒体用户新闻浏览数据,采用多层次线性回归分析探究移动媒体受众新闻消费多样性演化及其影响因素。首先,移动媒体受众新闻消费多样性随时间推移呈现较为稳定的变化趋势。其次,新闻推送对新闻消费多样性具有显著的正向影响,并对时间与新闻消费多样性之间的关系具有显著的正向调节作用。受众新闻消费主动性对新闻消费多样性具有显著的负向影响,并对时间与新闻消费多样性之间的关系具有显著的负向调节作用。

甲状腺超声智能诊断的现状及研究进展

近几十年在全球范围内甲状腺癌发病率增长迅速。超声检查是甲状腺结节诊断的首选检查手段。作为一项经济、便利且易于推广的检查项目,其对影像学医师的要求较高,需要有丰富的经验。超声检查对甲状腺癌的诊断标准也在不断完善,统一化标准的推广、普及和成熟利用在实施过程中需要大量的人力和财力,目前较难实现。近些年中国医疗卫生资源需求巨大,医疗资源分布欠均衡,临床诊疗中需要全面评估甲状腺结节的恶性风险和颈部淋巴结的性质以进行临床决策,诊断工作繁重复杂。人工智能领域的深度学习算法飞速发展,其在医学图像诊断领域展示出强大的性能,大数据结合深度学习可有效地解决临床诊疗中的问题,深度学习在医疗图像诊断领域、甲状腺结节超声诊断方向显示出较大的优势和应用前景。利用深度学习算法分析超声图像构建超声自动诊断系统,可辅助甲状腺肿瘤超声诊断,简化超声医生的工作流程,有助于提高临床实践效率。本文对近年来深度学习在甲状腺肿瘤及颈部淋巴结超声诊断领域的研究现状和研究进展予以概述。

中国影视剧海外社会化媒体传播模式分析:以《延禧攻略》为例

本研究以《延禧攻略》为典型案例,基于拉斯韦尔“5W”信息传播模式,深入量化分析以该作品为代表的中国影视剧海外社会化媒体传播模式,即传播主体、传播结构、传播内容和传播效果。本研究拓展了拉斯韦尔“5W”信息传播模式的理论视域,对于中国文化全球传播实践具有指导意义。同时,本研究所采纳的计算社会科学研究范式对中国文化对外传播的研究方法论层面具有借鉴意义。

诱导化疗在进展期头颈部鳞癌中的应用现状和研究进展

头颈部鳞状细胞癌(head and neck squamous cell carcinoma,HNSCC)是常见的恶性肿瘤。诱导化疗作为治疗进展期HNSCC的主要手段之一,得到广泛研究并应用于临床。然而,除了在器官保留方面以外,诱导化疗能否为患者带来获益一直存在争议。目前,TPF方案(多西他赛+顺铂+5-氟尿嘧啶)仍然是HNSCC诱导化疗的标准方案,但是TPF方案具有不良反应较大等问题。近年来,围绕着诱导化疗在进展期HNSCC的应用,产生较多的研究报道和循证医学证据。本文通过非系统性检索近年来所有进展期HNSCC诱导化疗的文献,就该领域研究现状进行综述,探讨诱导化疗标准方案的建立和其对患者生存及器官保留的临床意义,总结减少化疗相关不良反应的尝试,分析新的诱导化疗方案。

Comparison of Depression and Anxiety between Unmarried Female Youth in Two Groups of Induced Abortion and None-Induced Abortion in Yibin City of China

Objectives To explore the risk factors influencing the mental status of unmarried female youth. Methods ,4 cross-sectional survey and a qualitative interview were adopted. 1200 unmarried female volunteers （600 with 1,4） who aged 15-29 years in Yibin city were investigated, and 8 focus group discussions （FGDs） and 8 in-depth interviews were conducted. Except the investigation of subject＇s personal information, econ-socio status, sexual behavior, contraception and reproductive health problems they face, two selfreporting scales, CES-D and SAS were used for assessment of depression and anxiety of the subjects. Results 1） Depression and anxiety among unmarried female youth investigated in current study are relatively common. Proportions of the females with depression and anxiety to the total sample are 27.4% and 33.4%, respectively; 2） Depression and anxiety of the females with 1,4 are more serious than that of the female without 1,4. Proportions of unmarried females with IA have depression and anxiety to the total unmarried females with 1,4 are 3.45 times and 2.61 times that of unmarried females without 1,4 have depression and anxiety to the total unmarried females without 1,4, respectively; 3） IA is one of the key risk factors influencing depression and anxiety of unmarried female youth. Other risk factors are lack on basic knowledge about sex/ STD/HIV/AIDS, reproductive tract infections, relatively lower income, age at sex debut is relatively younger, etc. In addition, multiple sex partners and repeat pregnancies were risk factors influencing anxiety of unmarried female youth. Conclusion Depession and anxiety was more popular in unmarried females with IA Intervention for improving mental health of unmarried females should be developred Key words：

动画内容衍生品消费行为影响因素研究

本研究采用基于手机RDD的随机电话调查,结合二分logistics回归模型,以"启动效应"为视角,探究了用户对于动画衍生品消费行为的影响因素。研究发现,当前我国动画内容衍生品主要消费人群为较年轻的高收入高学历群体。此外,媒介接触时长对动画内容衍生品消费行为产生了重要影响。本研究检验了心理学领域的"启动效应"在媒介传播领域的应用可适性,同时为动画内容衍生品盈利模式提供了实践指导意义。

Research on Remaining Useful Life Prediction Method of Rolling Bearing Based on Health Indicator Extraction and Trajectory Enhanced Particle Filter

Aiming at the difficulty of mining fault prognosis starting points and constructing prognostic models for remaining useful life(RUL)prediction of rolling bearings,a RUL prediction method is proposed based on health indicator(HI)extraction and trajectory-enhanced particle filter(TE-PF).By extracting a HI that can accurately track the trending of bearing degradation and combining it with the early fault enhancement technology,early abnormal sample nodes can be mined to provide more samples with fault information for the construction and training of subsequent prediction models.Aiming at the problem that traditional degradation rate models based on PF are vulnerable to HI mutations,a TE-PF prediction method is proposed based on comprehensive utilization of historical degradation information to timely modify prediction model parameters.Results from a rolling bearing prognostic study show that prediction starting points can be accurately detected and a reasonable prediction model can be conveniently constructed by the RUL prediction method based on HI amplitude abnormal detection and TE-PF.Furthermore,aiming at the RUL prediction problem under the condition of HI mutation,RUL prediction with probability and statistics characteristics under a confidence interval can be obtained based on the method proposed.

Improved diagnosis of thyroid cancer aided with deep learning applied to sonographic text reports:a retrospective,multi-cohort,diagnostic study

Objective:Large volume radiological text data have been accumulated since the incorporation of electronic health record(EHR)systems in clinical practice.We aimed to determine whether deep natural language processing algorithms could aid radiologists in improving thyroid cancer diagnosis.Methods:Sonographic EHR data were obtained from the EHR database.Pathological reports were used as the gold standard for diagnosing thyroid cancer.We developed thyroid cancer diagnosis based on natural language processing(THCaDxNLP)to interpret unstructured sonographic text reports for thyroid cancer diagnosis.We used the area under the receiver operating characteristic curve(AUROC)as the primary metric to measure the performance of the THCaDxNLP.We compared the performance of thyroid ultrasound radiologists aided with THCaDxNLP vs.those without THCaDxNLP using 5 independent test sets.Results:We obtained a total number of 788,129 sonographic radiological reports.The number of thyroid sonographic data points was 132,277,18,400 of which were thyroid cancer patients.Among the 5 test sets,the numbers of patients per set were 439,186,82,343,and 171.THCaDxNLP achieved high performance in identifying thyroid cancer patients(the AUROC ranged from 0.857–0.932).Thyroid ultrasound radiologists aided with THCaDxNLP achieved significantly higher performances than those without THCaDxNLP in terms of accuracy(93.8%vs.87.2%;one-sided t-test,adjusted P=0.003),precision(92.5%vs.86.0%;P=0.018),and F1 metric(94.2%vs.86.4%;P=0.007).Conclusions:THCaDxNLP achieved a high AUROC for the identification of thyroid cancer,and improved the accuracy,sensitivity,and precision of thyroid ultrasound radiologists.This warrants further investigation of THCaDxNLP in prospective clinical trials.

Improving Sexual and Contraceptive Behaviours of Unmarried Female Youth with First Trimester Induced Abortion in Sichuan,China

Objectives To understand the changes on sexual and contraceptive behaviours of unmarried induced abortion（IA） youth by intervention in Sichuan, China; and to find a way to improve sexual and contraceptive behaviours of unmarried IA youth. Methods Intervention epidemiological surveys （baseline and evaluation） plus qualitative interview were used. During July 2002 and July 2003, 2 484 unmarried female volunteers who aged 15-29 years and come to clinics seeking abortion were recruited by cluster random sampling from the four selected regions of Sichuan, 48 volunteers were interviewed for 8 focusgroup discussions （FGDs） and 16 in-depth interviews equally for each survey. Information, education anol communication（IEC） materials, education sessions, trainings and counseling were given to subjects and service providers during the project implementation. Questionnaires for surveys and guidelines for qualitative interviews were used. Results Comparison of the after with the before intervention. 1） the proportion of respondents having knowledge about sexuality was increased by 13%. Among them, the proportion of respondents got part and most of the knowledge was increased by 43%. Maximum number of sex partners the respondents have decreased from 9 to 4. Respondents＇partnerships have gradually changed from more acquaintances/school mates/boyfriends to fianés mainly; 2） respondents＇ contraceptive use rate was increased by 20%. Among them, the condom use rate increased rapidly to 80%. Purposes of condom use were changed from only for contraception to for prevention of HIV/AIDS/STDs and pregnancy. And most of respondents stabilised their method use - condoms. Most of respondents suggested condoms was the method most suitable for unmarried IA youth, this proportion was increased by 44%; 3） proportion of respondents knowing more about consequences of induced abortion was increased by 24%; and 4） proportions of respondents having depression and anxiety symptoms were decreased by 66% and by 61%, respectively. Conclusion The intervention including IEC materials, education, training and counseling was effective in improving sexual and contraceptive behaviours of unmarried IA youth.

CeO_(2)-clay composites for ultra-long cycle life electrochemical capacitive energy storage application

The lattice expansion caused by the reduction of Ce(Ⅳ)to Ce(Ⅲ)impeded the development of the CeO_(2)as an effective electrode material for electrochemical supercapacitors.Herein,we prepared CeO_(2)-clay composites through a one-step hydrothermal method.The interlayer structures of clays efficiently accommodate volume changes induced by crystal lattice expansion to achieve ultra-long cycle stability.After 60000 charge-discharge cycles,the capacitance retention rate of the assembled asymmetric supercapacitors is as high as~-100%.The key findings of this work reveal the potential application of clays in achieving ultralong cycle stability of the CeO_(2)electrode material,paving the way for further application of the CeO_(2)in electrochemical energy storage.

Boosting the energy density of sulfide-based all-solid-state batteries at low temperatures by charging to high voltages up to 6 V

Sulfide electrolyte-based all-solid-state batteries(ASSBs)are potential next generation energy storage technology due to the high ionic conductivity of sulfide electrolytes and potentially improved energy density and safety.However,the performance of ASSBs at/below subzero temperatures has not been explored systematically.Herein,low temperature(LT)performance of LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)|Li_(9.54)Si_(1.74)P_(1.44)S11.7Cl_(0.3)(LiSPSCl)|Li_(4)Ti_(5)O_(12)(LTO)ASSBs was investigated.By charging the ASSB to 6 V at−40℃,a capacity of 100.7 mAh∙g^(−1)at 20 mA∙g^(−1)was achieved,which is much higher than that charged to 4.3 V(4.6 mAh∙g^(−1))at−40℃.Moreover,atomic resolution microscopy revealed that the NCM811 remained almost intact even after being charged to 6 V.In contrast,NCM811 was entirely destructed when charged to 6 V at room temperature.The sharp difference arises from the large internal charge transfer resistance at LT which requires high voltage to overcome.Nevertheless,such high voltage is not harmful to the active material but beneficial to extracting most energy out of the ASSBs at LT.We also demonstrated that thinner electrolyte is favorable for LT operation of ASSBs due to the reduced ion transfer distance.This work provides new strategies to boost the capacity and energy density of sulfide-based ASSBs at LT for dedicated LT applications.

Fc effector of anti-Aβ antibody induces synapse loss and cognitive deficits in Alzheimer’s disease-like mouse model

Passive immunotherapy is one of the most promising interventions for Alzheimer’s disease(AD).However,almost all immune-modulating strategies fail in clinical trials with unclear causes although they attenuate neuropathology and cognitive deficits in AD animal models.Here,we showed that Aβ-targeting antibodies including their lgG1 and lgG4 subtypes induced microglial engulfment of neuronal synapses by activating CR3 or FcγRIIb via the complex of Aβ,antibody,and complement.Notably,anti-Aβantibodies without Fc fragment,or with blockage of CR3 or FcγRIIb,did not exert these adverse effects.Consistently,Aβ-targeting antibodies,but not their Fab fragments,significantly induced acute microglial synapse removal and rapidly exacerbated cognitive deficits and neuroinflammation in APP/PS1 mice post-treatment,whereas the memory impairments in mice were gradually rescued thereafter.Since the recovery rate of synapses in humans is much lower than that in mice,our findings may clarify the variances in the preclinical and clinical studies assessing AD immunotherapies.Therefore,Aβ-targeting antibodies lack of Fc fragment,or with reduced Fc effector function,may not induce microglial synaptic pruning,providing a safer and more efficient therapeutic alternative for passive immunotherapy for AD.

小胶质细胞对阿尔兹海默病发生发展的影响作用

阿尔兹海默病（老年性痴呆,AD）是由β淀粉样蛋白（Aβ）和微管相关蛋白（Tau）聚集形成的具有毒性作用的寡聚物而引起的老年人主要以记忆力下降和脑部形成老年斑、神经纤维缠绕为特征的神经退行性疾病.小胶质细胞作为中枢神经系统中的固有免疫细胞,是脑内免疫监视的关键成分,发挥内源性免疫防御作用.正常生理状态的小胶质细胞能有效吞噬和清除毒性Aβ寡聚体,阻止AD发生.在AD病理过程中,过度激活的小胶质细胞通过补体依赖途径过度吞噬突触,导致突触丧失,同时大量释放炎症因子,促进Tau相关病理变化,对神经元造成直接损伤,导致认知功能下降.由此可见,小胶质细胞在AD发生发展过程中起着双刃剑的作用,探明小胶质细胞的极化状态及其在AD疾病机理中的作用将为攻克AD的药物研发提供突破性思路.要点：

Spirulina platensis aqueous extracts ameliorate colonic mucosal damage and modulate gut microbiota disorder in mice with ulcerative colitis by inhibiting inflammation and oxidative stress

Ulcerative colitis(UC)is a chronic and recurrent inflammatory bowel disease(IBD)that has become a major gastroenterologic problem during recent decades.Numerous complicating factors are involved in UC development such as oxidative stress,inflammation,and microbiota disorder.These factors exacerbate damage to the intestinal mucosal barrier.Spirulina platensis is a commercial alga with various biological activity that is widely used as a functional ingredient in food and beverage products.However,there have been few studies on the treatment of UC using S.platensis aqueous extracts(SP),and the underlying mechanism of action of SP against UC has not yet been elucidated.Herein,we aimed to investigate the modulatory effect of SP on microbiota disorders in UC mice and clarify the underlying mechanisms by which SP alleviates damage to the intestinal mucosal barrier.Dextran sulfate sodium(DSS)was used to establish a normal human colonic epithelial cell(NCM460)injury model and UC animal model.The mitochondrial membrane potential assay 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)and staining with Annexin V-fluorescein isothiocyanate(FITC)/propidium iodide(PI)and Hoechst 33258 were carried out to determine the effects of SP on the NCM460 cell injury model.Moreover,hematoxylin and eosin(H&E)staining,transmission electron microscopy(TEM),enzyme-linked immunosorbent assay(ELISA),quantitative real-time polymerase chain reaction(qPCR),western blot,and 16S ribosomal DNA(rDNA)sequencing were used to explore the effects and underlying mechanisms of action of SP on UC in C57BL/6 mice.In vitro studies showed that SP alleviated DSS-induced NCM460 cell injury.SP also significantly reduced the excessive generation of intracellular reactive oxygen species(ROS)and prevented mitochondrial membrane potential reduction after DSS challenge.In vivo studies indicated that SP administration could alleviate the severity of DSS-induced colonic mucosal damage compared with the control group.Inhibition of inflammation and oxidative stress was associated with increases in the activity of antioxidant enzymes and the expression of tight junction proteins(TJs)post-SP treatment.SP improved gut microbiota disorder mainly by increasing antioxidant enzyme activity and the expression of TJs in the colon.Our findings demonstrate that the protective effect of SP against UC is based on its inhibition of pro-inflammatory cytokine overproduction,inhibition of DSS-induced ROS production,and enhanced expression of antioxidant enzymes and TJs in the colonic mucosal barrier.

Interlayer material technology of manganese phosphate toward and beyond electrochemical pseudocapacitance over energy storage application

Manganese phosphates have shown excellent performances and great potential in electrochemical energy storage,which are demonstrated by research works published in recent years.For manganese phosphates,the open-framework structures with large channels and cavities endow them with good ion conductivity and charge storage capacity.In this review,we present the recent progress on manganese phosphates,by focusing on their advantages/disadvantages and potential applications as a new class of electrode materials in supercapacitors.The structural characteristics,synthesis methods,and mineral sources to prepare these manganese phosphates are investigated,together with the modification,as they strongly affect the electrochemical energy storage performance.Attentions are paid to those hybrid-type materials,where strong synergistic effects exist.In the summary,interlayer engineering for the manganese phosphates and hybrid-types are proposed and discussed.

Alkali cation intercalation manganese phosphate hydrate boosting electrochemical kinetics for pseudocapacitive energy storage

New insight into the effect on the alkali cations of Liþ,Naþ,and Kþpre-intercalated between adjacent layers of Mn3(PO4)2$3H2O towards the charge storage mechanism and their electrochemical kinetics of intercalation/deintercalation in three alkali electrolytes is demonstrated.The electrochemical perfor-mance of the designed LieMn3(PO4)2$3H2O material outperforms that most of Mn-based pseudocapa-citive electrode materials.The designed unique stratified structure is attractive for quick charge migration,which confirms that the appropriate pre-intercalation of alkali cation between layers is an efficient strategy to improve kinetics for the high-power density pseudocapacitive supercapacitor energy storage application.

Aggregation of CeAlO_(3) inclusions in heavy ingot of a steel containing 0.007% aluminum

The distribution of inclusions at the bottom of a Ce-treated heavy steel ingot was detected and calculated.The three-dimensional morphology and spatial distribution of CeAlOs clusters were characterized using the electrolytic extraction and Micro-CT detection.A model of inclusion collision to predict the aggregation of CeAlO_(3) inclusions in the ingot was established and validated by measured results.Inclusions were mainly CeAlO_(3) and a small amount of Ce_(2)O_(2)S in the tundish after cerium treatment.The collision and aggregation of inclusions led to the formation of large clusters in the ingot during the solidification process.Large slag entrainment inclusions,large CeAO_(3) clusters and small CeAlO_(3) particles were observed from the center to the edge of the ingot bottom.Large inclusions were mainly concentrated at the center.The number density of inclusions larger than 200μm was 0.21 mm^(-3).The maximum diameter of CeA1O_(3) clusters was 1340μm.From the edge to the radial center and from the bottom to the top,the average diameter of inclusions gradually increased due to the longer solidification time of the ingot.