Aggregation-based analytical chemistry in point-of-care nanosensors

It is crucial to realize the point-of-care(POC)testing of harmful analytes,capa-ble of saving limited agricultural resources,assisting environmental remediation,ensuring food safety,and enabling early disease diagnosis.Compared with other conventional POC sensing strategies,aggregation-based analytical chemistry facil-itates the practical-oriented development of POC nanosensors by altering the aggregation status of nanoprobes through the action of multiple aggregation-induced“forces”originating from the targets.Herein,we have proceeded with a comprehensive review focusing on the aggregation-based analytical chemistry in POC nanosensors,covering aggregation-induced“forces”,aggregation-induced signal transductions,aggregation-induced POC nanosensing strategies,and their applications in biomolecular monitoring,food safety analysis,and environmental monitoring.Finally,challenges existing in practical applications have been fur-ther proposed to improve their sensing applications,and we expect our review can speed up the development of cost-effective,readily deployable,and time-efficient nanosensors through aggregation-based analytical chemistry.

从纳米酶的视角探究农业食品安全的奥秘

Global climate changes,such as extreme weather,sea levels rise,and biodiversity decline,have destructive impacts on the global agrofood system,in terms of crop yield,agrofood quality and consumer safety.Those stressed conditions and environmental pollution for crop and agrofood prompt us to take immediate action to develop a whole-new-era agrofood system from the perspective of sustainability[1].