Recent advances in catalytic enantioselective direct C–H bond functionalization of electrondeficient N-containing heteroarenes

Catalytic enantioselective direct C–H bond functionalization of electron-deficient N-containing heteroarenes represents one of the most straightforward and powerful protocols to construct diverse enantioenriched highly functionalized N-heteroarene products.Efficient catalytic systems and a variety of strategies for highly chemo-and stereoselective C–H functionalization of electron-deficient N-containing heteroarenes have been developed over the past few decades.This review summarized the rapid progress in the catalytic asymmetric C–H functionalization of N-containing heteroarenes and discussed the challenges and potential of the field in the current stage.