Association between HLA-B and HLA-DRB1 polymorphisms and systemic lupus erythematosus in Han population in China

We explored the association between HLA-B and HLA-DRB1 polymorphisms and reviewed clinical characteristics of systemic lupus erythematosus(SLE)in Han population in Yunnan,China.Methods:There were 295 patients and 265 healthy control subjects(HCs)enrolled in the study.Clinical data and blood samples were collected from the patients.The HLA-B and HLA-DRB1 genotypes were detected in SLE patients and HCs.Results:A total of 74 genotypes on HLA-B loci were determined in 288 patients as well as 57 genotypes in 265 HCs.The results showed SLE was associated with the HLA-B*40:01 and HLA-DRB1*08:03 alleles,and the HLAB*46:01,HLA-DRB1*12:02,DRB1*04:03,DRB1*14:01,DRB1*04:06,and DRB1*11:01 alleles were less likely to appear in SLE patients.Additionally,HLA-B*07:02 and B*40:06 were associated with disease activity.HLADRB1*03:01,DRB1*13:02,and DRB1*12:01 were associated with proteinuria.Furthermore,HLA-B*51:01,B*13:02,B*38:02,B*35:01,HLA-DRB1*15:02,DRB1*15:04,DRB1*15:01,and DRB1*08:03 were correlated with inflammatory factors and immune dysfunction.HLA-B*15:25 was related to the production of multiple antibodies.HLA-DRB1*12:02 might be a protective factor for pancytopenia.The haplotype of HLA-B*40:01/DRB1*08:03 was linked with SLE.Conclusion:SLE in Han population in Yunnan province was associated with the HLA-B*40:01 and HLA-DRB1*08:03 alleles,and the haplotype HLAB*40:01/DRB1*08:03.Several alleles were associated with inflammation,immune disorders,and organ involvement in SLE.Those alleles might be potential genetic markers of SLE.