Background: Recently, it has been shown that UVB phototherapymay bemore effect ive than UVA in the treatment of vitiligo. Currently, however, no studies have c ompared the efficacy of UVB 311 nm and broad-band UVB the...Background: Recently, it has been shown that UVB phototherapymay bemore effect ive than UVA in the treatment of vitiligo. Currently, however, no studies have c ompared the efficacy of UVB 311 nm and broad-band UVB therapy. Calcipotriol has recently been reported to be effective adjunctive treatment for vitiligo, enhan cing the efficacy of 8-methoxypsoralen plus UVA (PUVA) therapy. Methods: Ten pa tients were enrolled in the study; nine completed the 12 months of therapy. The upper part of the body was treated twice weekly with UVB 311 nm and the lower pa rt with broad-band UVB. Calcipotriolwas applied onto the vitiligo lesions of th e right side of the body and placebo on the left side. Repigmentation was docume nted by photography, planimetry, and Vitiligo Disease Activity (VIDA) score. The quality of life was measured by the Dermatology Life Quality Index (DLQI). Resu lts: After 7-16 weeks, six of the nine patients showed initial repigmentation o n the side treated with UVB311 nm. After 6 months of treatment, none of the patients showed repigmentation on the areas treated wit h broad-band UVB, which prompted us to apply UVB 311 nm all over the body. At t he end of 12 months, two patients showed > 75%repigmentation, two showed 51-75 %, two showed 26-50%, and three showed 0-25%. In all patients with progress ive vitiligo (seven of the nine patients), disease activity was stopped. Remarka bly, vitiligo lesions treated with calcipotriol initially showed delayed repigme ntation compared with control areas; however, there was no therapeutic differenc e between calcipotriol and placebo, both in combination with UVB 311 nm, by the end of the study.The DLQI score improved significantly by an average of 28%. Co nclusion: UVB 311 nm therapy was effective in the treatment of vitiligo, whereas broad-band UVB had no effect. Combination with calcipotriol ointment was not s uperior to UVB 311 nm monotherapy.The quality of life significantly improved wit h narrow-band UVB 311 nm phototherapy.展开更多
文摘Background: Recently, it has been shown that UVB phototherapymay bemore effect ive than UVA in the treatment of vitiligo. Currently, however, no studies have c ompared the efficacy of UVB 311 nm and broad-band UVB therapy. Calcipotriol has recently been reported to be effective adjunctive treatment for vitiligo, enhan cing the efficacy of 8-methoxypsoralen plus UVA (PUVA) therapy. Methods: Ten pa tients were enrolled in the study; nine completed the 12 months of therapy. The upper part of the body was treated twice weekly with UVB 311 nm and the lower pa rt with broad-band UVB. Calcipotriolwas applied onto the vitiligo lesions of th e right side of the body and placebo on the left side. Repigmentation was docume nted by photography, planimetry, and Vitiligo Disease Activity (VIDA) score. The quality of life was measured by the Dermatology Life Quality Index (DLQI). Resu lts: After 7-16 weeks, six of the nine patients showed initial repigmentation o n the side treated with UVB311 nm. After 6 months of treatment, none of the patients showed repigmentation on the areas treated wit h broad-band UVB, which prompted us to apply UVB 311 nm all over the body. At t he end of 12 months, two patients showed > 75%repigmentation, two showed 51-75 %, two showed 26-50%, and three showed 0-25%. In all patients with progress ive vitiligo (seven of the nine patients), disease activity was stopped. Remarka bly, vitiligo lesions treated with calcipotriol initially showed delayed repigme ntation compared with control areas; however, there was no therapeutic differenc e between calcipotriol and placebo, both in combination with UVB 311 nm, by the end of the study.The DLQI score improved significantly by an average of 28%. Co nclusion: UVB 311 nm therapy was effective in the treatment of vitiligo, whereas broad-band UVB had no effect. Combination with calcipotriol ointment was not s uperior to UVB 311 nm monotherapy.The quality of life significantly improved wit h narrow-band UVB 311 nm phototherapy.
