Heart failure is common in older people and its prevalence is increasing.The Heart 'omics' in AGEing(HOMAGE) project aims to provide a biomarker approach that will improve the early diagnosis of heart failure.A la...Heart failure is common in older people and its prevalence is increasing.The Heart 'omics' in AGEing(HOMAGE) project aims to provide a biomarker approach that will improve the early diagnosis of heart failure.A large clinical database,based on(1) prospective population studies or(2) cross-sectional,prospective studies or randomized controlled trials(RCTs) of patients at risk for or with overt cardiovascular disease will be constructed to determine most promising 'omics'-based biomarkers to identify the risk of developing heart failure and/or comorbidities.Population studies,patient cohorts and RCTs are eligible for inclusion in the common database,if they received ethical approval to obtain and share data and have baseline information on cardiovascular risk factors.Currently,the HOMAGE database includes 43,065 subjects,from 20 studies in eight European countries,including healthy subjects from three population studies in France,Belgium and Italy(n = 7,124),patients with heart failure(n = 4,312) from four cohorts in the UK,Spain and Switzerland and patients at high risk for cardiovascular disease(n = 31,629) in 13 cohorts.It is anticipated that more partners will join the consortium and enlarge the pooled data.This large merged database will be a useful resource with which to identify candidate biomarkers that play a role in the mechanism underlying the onset and progression of heart failure.展开更多
目的评价对于中国患者脑血管病后降压治疗是否可以预防脑卒中再发。方法采取双盲、安慰剂对照的试验方法,将患者随机分入对照组(n=2825)和干预组(吲达帕胺2.5 mg/d,n=2840)。一级终点事件为致死或非致死性再发脑卒中,二级终点事件为主...目的评价对于中国患者脑血管病后降压治疗是否可以预防脑卒中再发。方法采取双盲、安慰剂对照的试验方法,将患者随机分入对照组(n=2825)和干预组(吲达帕胺2.5 mg/d,n=2840)。一级终点事件为致死或非致死性再发脑卒中,二级终点事件为主要的致死或非致死心血管病事件。结果平均收缩压和舒张压分别为153.8和92.8 mm Hg。在随访中期(第2年),干预组收缩压/舒张压较对照组平均下降了6.8/3.3 mm Hg。干预组总共有159例再发脑卒中,对照组为219例(干预组HR=0.70;95%CI0.57~0.86;P<0.01)。干预组有199例发生心血管病事件,对照组为258例(HR=0.74;95%CI0.62~0.89;P=0.002)。结论吲达帕胺降压治疗可以降低中国人脑血管病患者再发脑卒中和心血管病事件。展开更多
文摘Heart failure is common in older people and its prevalence is increasing.The Heart 'omics' in AGEing(HOMAGE) project aims to provide a biomarker approach that will improve the early diagnosis of heart failure.A large clinical database,based on(1) prospective population studies or(2) cross-sectional,prospective studies or randomized controlled trials(RCTs) of patients at risk for or with overt cardiovascular disease will be constructed to determine most promising 'omics'-based biomarkers to identify the risk of developing heart failure and/or comorbidities.Population studies,patient cohorts and RCTs are eligible for inclusion in the common database,if they received ethical approval to obtain and share data and have baseline information on cardiovascular risk factors.Currently,the HOMAGE database includes 43,065 subjects,from 20 studies in eight European countries,including healthy subjects from three population studies in France,Belgium and Italy(n = 7,124),patients with heart failure(n = 4,312) from four cohorts in the UK,Spain and Switzerland and patients at high risk for cardiovascular disease(n = 31,629) in 13 cohorts.It is anticipated that more partners will join the consortium and enlarge the pooled data.This large merged database will be a useful resource with which to identify candidate biomarkers that play a role in the mechanism underlying the onset and progression of heart failure.
文摘目的评价对于中国患者脑血管病后降压治疗是否可以预防脑卒中再发。方法采取双盲、安慰剂对照的试验方法,将患者随机分入对照组(n=2825)和干预组(吲达帕胺2.5 mg/d,n=2840)。一级终点事件为致死或非致死性再发脑卒中,二级终点事件为主要的致死或非致死心血管病事件。结果平均收缩压和舒张压分别为153.8和92.8 mm Hg。在随访中期(第2年),干预组收缩压/舒张压较对照组平均下降了6.8/3.3 mm Hg。干预组总共有159例再发脑卒中,对照组为219例(干预组HR=0.70;95%CI0.57~0.86;P<0.01)。干预组有199例发生心血管病事件,对照组为258例(HR=0.74;95%CI0.62~0.89;P=0.002)。结论吲达帕胺降压治疗可以降低中国人脑血管病患者再发脑卒中和心血管病事件。