During the past few years,electrochemical oxidative reactions through radical intermediates have emerged as an environmentally-benign,powerful platform for the facile formation of C–E(E=C,N,S,Se,O and Hal)bonds throu...During the past few years,electrochemical oxidative reactions through radical intermediates have emerged as an environmentally-benign,powerful platform for the facile formation of C–E(E=C,N,S,Se,O and Hal)bonds through singleelectron-transfer(SET)processes at the electrodes.Functionalized unsaturated molecules and unusual structural motifs can,for instance,be directly constructed under exceedingly mild reaction conditions through initial radical attack onto alkynes.This minireview highlights the recent advances in electrooxidation in radical reactions until June 2022,with a particular focus on radical additions onto alkynes.展开更多
In recent years,molecular electrochemistry has undergone a remarkable renaissance to surface as a sustainable strategy for organic synthesis and catalysis,gaining considerable momentum by the use of renewable forms of...In recent years,molecular electrochemistry has undergone a remarkable renaissance to surface as a sustainable strategy for organic synthesis and catalysis,gaining considerable momentum by the use of renewable forms of energy[1,2].Modern organic electrochemistry has the unique power to control chemo-,regio-,and position-selectivities through the judicious choice of the electrode material,the applied potential or an additional catalyst,among others[1,2].Despite the major advances in molecular electrochemistry,these approaches continue to predominantly rely on non-renewable fossil resources.展开更多
While electrocatalyzed alkyne annulations of arenes represent a powerful strategy for the assembly of heteroaromatic motives,electrochemical C(sp2)−H activations of alkenes remain scarce.Herein,a strategy for the rhod...While electrocatalyzed alkyne annulations of arenes represent a powerful strategy for the assembly of heteroaromatic motives,electrochemical C(sp2)−H activations of alkenes remain scarce.Herein,a strategy for the rhodaelectro-catalyzed function-alization of enamides is presented for the efficient construction of pyrroles using electricity as a sustainable oxidant.Moreover,the tuning of the solvent system allowed a fascinating switch in chemoselectivity,which is not possible with traditionally used chemical oxidants,giving rise to lactone architectures.The rhoda-electrocatalysis features a broad scope as well as high regio-and chemoselectivities.展开更多
Cobaltaelectrocatalysis set the stage for sustainable C—H acyloxylations in biomass-derived γ-valerolactone as a renewable solvent. The sustainable electrocatalysis regime featured ample scope, along with high level...Cobaltaelectrocatalysis set the stage for sustainable C—H acyloxylations in biomass-derived γ-valerolactone as a renewable solvent. The sustainable electrocatalysis regime featured ample scope, along with high levels of chemo- and position-selectivity.展开更多
Rhodium(III)catalysis has set the stage for a plethora of oxidative C–H functionalizations over the last decade,which have predominantly employed stoichiometric amounts of toxic and expensive metal oxidants,such as s...Rhodium(III)catalysis has set the stage for a plethora of oxidative C–H functionalizations over the last decade,which have predominantly employed stoichiometric amounts of toxic and expensive metal oxidants,such as silver(I)salts.In the meantime,electrosynthesis has emerged as an increasingly viable alternative for expensive and toxic oxidants.Recently,significant momentum has been achieved with the merger of electrocatalysis with organometallic C–H activation.However,user-friendly and robust rhodaelectro-catalysis has until very recently proven elusive for oxidative C–H activations.This minireview highlights the current knowledge and recent advances of electrooxidation in rhodium-catalyzed C–H or C–C activations,with a topical focus on contributions from the Ackermann group through July 2020.展开更多
Molecular electrochemistry has emerged as an environmentally-friendly platform.While major recent momentum was gained in electrocatalyzed bond activations by earth-abundant 3 d transition metals[1],cost-effective nick...Molecular electrochemistry has emerged as an environmentally-friendly platform.While major recent momentum was gained in electrocatalyzed bond activations by earth-abundant 3 d transition metals[1],cost-effective nickela-electrocatalysis continuous to be underdevelopment for electrocatalysis[2].Nickel is an essential component of metalloproteins involved in catalytic aerobic oxygenation processes,for which nickel-dioxygen species were proposed as the key catalytic species[3].展开更多
We report the establishment of a rhodaelectrocatalyzed[5+2]N-H/C-H oxidative annulation of alkynes by 7-arylindoles,enabling the synthesis of seven-membered azepino[3,2,1-hi]indoles using electricity as the sole oxida...We report the establishment of a rhodaelectrocatalyzed[5+2]N-H/C-H oxidative annulation of alkynes by 7-arylindoles,enabling the synthesis of seven-membered azepino[3,2,1-hi]indoles using electricity as the sole oxidant.The reaction could be scaled up to gram-scale by flow-electrocatalysis.Two key rhodium(Ⅲ)intermediates were isolated and fully characterized.Cyclovoltammetric analysis,X-ray photoelectron spectroscopy studies,and density functional theory calculations are suggestive of a rhodium(Ⅲ-Ⅳ-Ⅱ-Ⅲ)manifold.展开更多
基金supported by the Natural Science Foundation of Zhejiang Province(LY22B020001)the National Natural Science Foundation of China(21702188)+1 种基金the ERC Advanced Grant(101021358)the Gottfried-Wilhelm-Leibniz award to LA(DFG).
文摘During the past few years,electrochemical oxidative reactions through radical intermediates have emerged as an environmentally-benign,powerful platform for the facile formation of C–E(E=C,N,S,Se,O and Hal)bonds through singleelectron-transfer(SET)processes at the electrodes.Functionalized unsaturated molecules and unusual structural motifs can,for instance,be directly constructed under exceedingly mild reaction conditions through initial radical attack onto alkynes.This minireview highlights the recent advances in electrooxidation in radical reactions until June 2022,with a particular focus on radical additions onto alkynes.
文摘In recent years,molecular electrochemistry has undergone a remarkable renaissance to surface as a sustainable strategy for organic synthesis and catalysis,gaining considerable momentum by the use of renewable forms of energy[1,2].Modern organic electrochemistry has the unique power to control chemo-,regio-,and position-selectivities through the judicious choice of the electrode material,the applied potential or an additional catalyst,among others[1,2].Despite the major advances in molecular electrochemistry,these approaches continue to predominantly rely on non-renewable fossil resources.
基金Generous support from ERC Advanced Grant 101021358 and the DFG Gottfried Wilhelm Leibniz award(L.A.)is gratefully acknowledged.E.R.thanks the Basque Government(Grupos IT1558-22)for financial support.
文摘While electrocatalyzed alkyne annulations of arenes represent a powerful strategy for the assembly of heteroaromatic motives,electrochemical C(sp2)−H activations of alkenes remain scarce.Herein,a strategy for the rhodaelectro-catalyzed function-alization of enamides is presented for the efficient construction of pyrroles using electricity as a sustainable oxidant.Moreover,the tuning of the solvent system allowed a fascinating switch in chemoselectivity,which is not possible with traditionally used chemical oxidants,giving rise to lactone architectures.The rhoda-electrocatalysis features a broad scope as well as high regio-and chemoselectivities.
基金Project supported by the National Natural Science Foundation of China(No.21801018)the Beijing Institute of Technology Research Fund Program for Young Scholars(No.1230011181807)~~
文摘Cobaltaelectrocatalysis set the stage for sustainable C—H acyloxylations in biomass-derived γ-valerolactone as a renewable solvent. The sustainable electrocatalysis regime featured ample scope, along with high levels of chemo- and position-selectivity.
基金support by the Deutsche Forschungsgemeinschaft(German Research Foundation)(Gottfried-Wilhelm-Leibniz award to L.A.)and the China Scholarship Council(fellowship to C.Z.)is gratefully acknowledged.
文摘Rhodium(III)catalysis has set the stage for a plethora of oxidative C–H functionalizations over the last decade,which have predominantly employed stoichiometric amounts of toxic and expensive metal oxidants,such as silver(I)salts.In the meantime,electrosynthesis has emerged as an increasingly viable alternative for expensive and toxic oxidants.Recently,significant momentum has been achieved with the merger of electrocatalysis with organometallic C–H activation.However,user-friendly and robust rhodaelectro-catalysis has until very recently proven elusive for oxidative C–H activations.This minireview highlights the current knowledge and recent advances of electrooxidation in rhodium-catalyzed C–H or C–C activations,with a topical focus on contributions from the Ackermann group through July 2020.
文摘Molecular electrochemistry has emerged as an environmentally-friendly platform.While major recent momentum was gained in electrocatalyzed bond activations by earth-abundant 3 d transition metals[1],cost-effective nickela-electrocatalysis continuous to be underdevelopment for electrocatalysis[2].Nickel is an essential component of metalloproteins involved in catalytic aerobic oxygenation processes,for which nickel-dioxygen species were proposed as the key catalytic species[3].
基金the National Natural Science Foundation of China(NSFCgrant no.21872028)+2 种基金the Natural Science Foundation of Fujian Province(grant no.2020J01149)the Fujian Province University Fund for New Century Excellent Talents is greatly acknowledgedfunding from the STU Scientific Research Foundation for Talents(no.NTF20022).
文摘We report the establishment of a rhodaelectrocatalyzed[5+2]N-H/C-H oxidative annulation of alkynes by 7-arylindoles,enabling the synthesis of seven-membered azepino[3,2,1-hi]indoles using electricity as the sole oxidant.The reaction could be scaled up to gram-scale by flow-electrocatalysis.Two key rhodium(Ⅲ)intermediates were isolated and fully characterized.Cyclovoltammetric analysis,X-ray photoelectron spectroscopy studies,and density functional theory calculations are suggestive of a rhodium(Ⅲ-Ⅳ-Ⅱ-Ⅲ)manifold.