Choriocarcinoma-associated pulmonary thromboembolism and pulmonary hypertension： a case report

Cases of pulmonary embolism and pulmonary artery hypertension caused by choriocarcinoma represent a rare clinical emergency. We report a case of a 25-year-old woman who presented with pulmonary embolism and hyper- tension and died soon after complete pulmonary embolectomy. A related literature review revealed that almost all of these patients had previously experienced a spontaneous abortion （average, 6 months） and were not pregnant.

Relation or Influence of RVOTO in the Inflammatory Response to Reoxygenation in Patients with Tetralogy of Fallot

Background:This study evaluated differential inflammatory response to cardiopulmonary bypass reoxygenation in tetralogy of Fallot repair.Methods:We performed a retrospective study at a cardiovascular center from 2012 to 2018,including 500 patients aged 1 week–18 years who received complete repair of tetralogy of Fallot.Patients were grouped according to tertiles of preoperative RVOT gradient on echocardiography into mild,moderate,and severe stenosis.We measured the highest perfusate oxygenation(PpO_(2))during aortic occlusion as independent variable.Primary outcome was systemic inflammatory response syndrome(SIRS)within 7 days postoperatively or the time of death or discharge.Results:Overall,rate of SIRS was 24.2% without significant differences among three groups(P>0.05).Older age,male,and smaller indexed left ventricular end-diastolic volume is independent risk factor of SIRS.There were significant interactions between RVOT stenosis and PpO2 on SIRS(P interaction=0.011):higher PpO_(2) was associated with a greater SIRS risk among combined moderate and severe stenotic children(OR 1.46395%CI[1.080,1.981]per-SD increase,P=0.014)but not among mild stenotic children(OR 0.900[0.608,1.333]per-SD increase;P=0.600),independent of covariates.Conclusion:The association of PpO_(2) with SIRS was modified by RVOT obstruction severity in tetralogy of Fallot repair.

RGB阵列式荧光传感技术用于检测高原湖泊中多种重金属离子

众所周知,重金属离子难在自然界中降解,一定量的重金属离子会在生物体中发生富集,严重威胁生命体健康。云南省拥有丰富的高原湖泊淡水资源,开展对高原湖泊重金属污染的研究,有助于深入了解高原湖泊重金属污染的现状,为其治理提供依据。荧光探针在重金属离子检测方面具有灵敏度高、选择性好、操作简单等优点。本新创实验将合成三种不同荧光发射的纳米材料:碳点(CDs,蓝色)、量子点(CdTeQDs,绿色)、金纳米簇(AuNCs,红色)。在96孔板中,分别加入以上三种荧光纳米探针以及CDs和Au NCs的混合式比率型探针,形成5×12的阵列形式,通过荧光猝灭及比率荧光的方式实现对高原湖泊水样中Pb^(2+)、Cu^(2+)、Hg^(2+)的检测。本实验还在紫外灯下,借助智能手机APP——ColorimeterX读取溶液的R、G、B值,基于此可实现金属离子的便捷式检测。本新创实验仪器小型化、高通量检测、视觉效果好,在应用于高校综合性实验开展方面,可解决部分高校实验仪器短缺、本科实验枯燥、与科研前沿相脱轨的问题。

目标责任制能否提高政府回应性?——基于保障性住房政策的分析

【问题】目标责任制已作为绩效管理的有效方式被广泛实践。大量研究揭示出目标责任制在强化地方政府的政治激励、改善政策执行力度中的作用,但较少研究关注自上而下的目标考核机制对政府回应性的意义。本研究以保障性住房政策为例,考察目标责任制在强化地方政府政策遵从行为的同时,是否会提高地方政府对当地公众诉求的重视程度及回应性。【方法】本研究以保障性住房政策执行与建设目标考核为例,结合“人民网地方领导留言板”政务大数据与政府工作报告文本数据,构建2010—2015年间全国327个城市的面板数据库,运用多层模型探究目标责任制下的保障性住房政策执行压力对地方政府回应性的影响。【发现】“十二五”期间,保障房建设目标更多、目标责任制压力更大的城市对本地居民住房诉求的回应度并未显著增加;相反,房价收入比较高、住房需求较大的城市,当地官员对公民住房诉求的回应性较低。【贡献】在社会民生类政策领域,目标责任制在促使地方政府主动回应公民诉求方面的作用有限。本研究对完善责任监督制、完善住房保障政策体系有所借鉴和参考。

Bioprosthetic Valve Size Selection to Optimize Aortic Valve ReplacementSurgical Outcome: A Fluid-Structure Interaction Modeling Study

Aortic valve replacement(AVR)remains a major treatment option for patients with severe aortic valve disease.Clinical outcome of AVR is strongly dependent on implanted prosthetic valve size.Fluid-structure interaction(FSI)aortic root models were constructed to investigate the effect of valve size on hemodynamics of the implanted bioprosthetic valve and optimize the outcome of AVR surgery.FSI models with 4 sizes of bioprosthetic valves(19(No.19),21(No.21),23(No.23)and 25 mm(No.25))were constructed.Left ventricle outflow track flow data from one patient was collected and used as model flow conditions.Anisotropic Mooney–Rivlin models were used to describe mechanical properties of aortic valve leaflets.Blood flow pressure,velocity,systolic valve orifice pressure gradient(SVOPG),systolic cross-valve pressure difference(SCVPD),geometric orifice area,and flow shear stresses from the four valve models were compared.Our results indicated that larger valves led to lower transvalvular pressure gradient,which is linked to better post AVR outcome.Peak SVOPG,mean SCVPD and maximum velocity for Valve No.25 were 48.17%,49.3%,and 44.60%lower than that from Valve No.19,respectively.Geometric orifice area from Valve No.25 was 52.03%higher than that from Valve No.19(1.87 cm2 vs.1.23 cm2).Implantation of larger valves can significantly reduce mean flow shear stress on valve leaflets.Our initial results suggested that larger valve size may lead to improved hemodynamic performance and valve cardiac function post AVR.More patient studies are needed to validate our findings.

Method for the automatic recognition of cropland headland images based on deep learning

For self-driving agricultural vehicles,the sensing of the headland environment based on image recognition is an important technological aspect.Cropland headland environments are complex and diverse.Traditional image feature extraction methods have many limitations.This study proposed a method of automatic cropland headland image recognition based on deep learning.Based on the characteristics of cropland headland environments and practical application needs,a dataset was constructed containing six categories of annotated cropland headland images and an augmented headland image training set was used to train the compact network MobileNetV2.Under the same experimental conditions,the model prediction accuracy for the first ranked category in all the results(Top-1 accuracy)of the MobileNetV2 network on the validation set was 98.5%.Compared with classic ResNetV2-50,Inception-V3,and backend-compressed Inception-V3,MobileNetV2 has a high accuracy,high recognition speed,and a small memory footprint.To further test the performance of the model,250 images were used for each of the six categories of headland images as the test set for the experiments.The average of the harmonic mean of precision and recall(F1-score)of the MobileNetV2 network for all the categories of headland images reached 97%.The MobileNetV2 network exhibits good robustness and stability.The results of this study indicate that onboard computers on self-driving agricultural vehicles are able to employ the MobileNetV2 network for headland image recognition to meet the application requirements of headland environment sensing.

Chromosome doubling of Sedum alfredii Hance: A novel approach for improving phytoremediation efficiency

Sedum alfredii Hance is a cadmium(Cd)/zinc(Zn)hyperaccumulator native to China.However,its relatively low biomass restricted the large-scale application for heavy metal contamination remediation.The chromosome set doubling of S.alfredii in vitro was achieved by 0.1%–0.2%(W/V)colchicine treatment.The plant DNA ploidy was analyzed by flow cytometry and chromosome set doubling plants(CSD)were identified based on the obvious different sharp peak.A tissue culture experiment with different Cd treated levels and a field trial with natural polluted mined soil were conducted to study the effects of chromosome doubling on plant biomass and Cd accumulation in shoots.The results suggested that S.alfredii is a mixoploid.Compared with the wild type plants(WT),CSD exhibited typical"gigas"characteristics in morphology including stem thickness,root hair production,number of leaves and size of stoma guard cell.Fresh weight and dry weight of CSD were increased to 1.62–2.03-fold and 2.26–3.25-fold of WT.And Cd content of CSD showed a17.49%–42.82%increase and 59%increase under tissue culture and field condition,accordingly.In addition,the TF and in BCF of CSD were 2.37-and 1.59-fold of WT,respectively.These results proved that it is feasible to promote phytoextraction efficiency of S.alfredii in Cd contaminated soils through chromosomal engineering,which provides a novel approach for hyperaccumulator application in phytoremediation.

Positive effects of applying endophytic bacteria in eggplant-Sedum intercropping system on Cd phytoremediation and vegetable production in cadmium polluted greenhouse

The combination of intercropping and phytoremediation in the remediation of cadmium contaminated soil is an emerging model in recent years,but the results of previous studies are inconsistent.In the field experiment,eggplant was intercropped with hyperaccumula-tor Sedum alfredii Hance(inoculated or not inoculated with endophytic bacteria)to study the effects of intercropping on vegetable safety production,phytoremediation efficiency of hyperaccumulator and variation of soil available nutrients.The results showed that the in-tercropping treatment had a negative effect on the growth of eggplant and Sedum,but en-dophyte SaMR12 alleviated the inhibition of intercropping on plant growth.Intercropping treatment increases the Cd concentration in edible part of eggplant to 1.34 mg/kg compared with eggplant monoculture(1.19 mg/kg).While the application of SaMR12 reduces the Cd concentration of eggplant fruit to 0.95 mg/kg and significantly promotes the Cd uptake by Sedum.What's more surprising is that compared with eggplant monocropping,the con-tent of soil available nitrogen,phosphorus and potassium in the treatment of intercropping with inoculated Sedum increased significantly.And according to the correlation analysis of various indexes of plants and soil,the Cd content of eggplant is negatively correlated with the available phosphorus and potassium in the soil,while the Cd content of Sedum is positively correlated with it,which suggested that the application of phosphorus and potas-sium fertilizers in this experimental site was beneficial to reduce Cd content in eggplant and improve Cd phytoextraction of Sedum.Therefore,in the daily production of moderately Cd-contaminated soil,intercropping eggplant with Sedum inoculated with endophytic bacteria is an excellent Phytoextraction Coupled with Agro-safe-production(PCA)pattern.

Impact of lactic acid bacteria on the control of Listeria monocytogenes in ready-to-eat foods

Due to the increased demand for ready-to-eat(RTE)minimally processed foods,alternatives to chemical and thermal preservation methods to maintain food safety are highly demanded.A significant safety hazard in RTE food products is the growth of the foodborne pathogen Listeria monocytogenes(L.monocytogenes).After processing,recontamination or cross-contamination of L.monocytogenes in RTE food products may occur and the lack of cooking can lead to an increased risk of listeriosis.Further,some RTE food products(e.g.cheese and cured meat)can have a long processing period and shelf life,thus allowing for the growth and proliferation of L.monocytogenes in the food matrix.Lactic acid bacteria(LAB)are generally recognized as safe probiotics and have been proposed as a biological control approach to eliminate foodborne pathogens including L.monocytogenes.LAB have been reported to extend the shelf life of food products and inhibit pathogen proliferation via growth competition and metabolite production.LAB are native microflora of many RTE foods,but only certain LAB may inhibit pathogen growth.Therefore,the specificity of LAB species should be employed in their use in RTE foods.This review will discuss the antimicrobial mechanisms of LAB against L.monocytogenes,selective use of LAB in food matrices,and their uses in food processing and packaging.

严景耀先生的犯罪学研究与实践历程考证

纵观严景耀先生的学术研究和社会实践生涯,其从事犯罪学研究始于1927年夏到监狱开展调查,至1936年离开燕京大学,前后约9年时间,其犯罪学相关的著述集中产出于这一时期;此外,其1957年作为全国人大代表参观考察监狱工作后,又形成了新的研究成果。严景耀先生的犯罪学相关的实践,集中于1928年夏至1929年11月推动创办《监狱杂志》并担任第一期总编辑,以及1936年9月至1943年8月担任上海公共租界工部局监狱帮办狱务监督和助理狱务监督期间。